4-(2-hydroxy-3-(naphthalen-1-yloxy)propylamino)-2,2,6,6-tetramethyl-1-oxylpiperidine | 56490-29-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(2-hydroxy-3-(naphthalen-1-yloxy)propylamino)-2,2,6,6-tetramethyl-1-oxylpiperidine
• 英文别名: 4-<<2-Hydroxy-3-(1-naphthalenyloxy)propyl>amino>-2,2,6,6-tetramethyl-1-piperidinyloxy；4-{[2-Hydroxy-3-(1-naphthalenyloxy)propyl]amino}-2,2,6,6-tetramethyl-1-piperidinyloxy
• CAS: 56490-29-0
• 化学式: C₂₂H₃₁N₂O₃
• 分子量: 371.5
• InChiKey: PRXQWLCJHNTKCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  45.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(2-hydroxy-3-(naphthalen-1-yloxy)propylamino)-2,2,6,6-tetramethyl-1-oxylpiperidine 在 苯肼 作用下， 生成 4-[[2-Hydroxy-3-(1-naphthalenyloxy)propyl]amino]-2,2,6,6-tetramethyl-1-piperidinyloxy
  参考文献：
  名称：

  Microwave-assisted synthesis of amphiphilic spin probes

  摘要：

  New amphiphilic nitroxide spin probes have been synthesized. The key reaction is based on microwave-assisted epoxide ring opening with amines as nucleophiles using Calcium triflouromethanesulfonate as a catalyst. High yields, in short reaction times, were obtained without any detectable nitroxide decomposition. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.11.065
• 作为产物：
  描述：

  3-(1-萘氧基)-1,2-环氧丙烷 、 4-氨基-TEMPO 在 calcium(II) trifluoromethanesulfonate 作用下， 以 1,4-二氧六环 为溶剂， 140.0 ℃ 、300.01 kPa 条件下， 反应 0.33h， 以91%的产率得到4-(2-hydroxy-3-(naphthalen-1-yloxy)propylamino)-2,2,6,6-tetramethyl-1-oxylpiperidine
  参考文献：
  名称：

  Microwave-assisted synthesis of amphiphilic spin probes

  摘要：

  New amphiphilic nitroxide spin probes have been synthesized. The key reaction is based on microwave-assisted epoxide ring opening with amines as nucleophiles using Calcium triflouromethanesulfonate as a catalyst. High yields, in short reaction times, were obtained without any detectable nitroxide decomposition. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.11.065