1-(p-methoxyphenyl)-2-tetralone | 503131-11-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-(p-methoxyphenyl)-2-tetralone
• 英文别名: 1-(4-methoxyphenyl)-3,4-dihydronaphthalen-2(1H)-one；1-(4-methoxyphenyl)-3,4-dihydro-1H-naphthalene-2-one；1-(4-methoxyphenyl)-3,4-dihydro-1H-naphthalen-2-one
• CAS: 503131-11-1
• 化学式: C₁₇H₁₆O₂
• 分子量: 252.313
• InChiKey: KNLADCBCRUFRFE-UHFFFAOYSA-N

物化性质

• 沸点：
  407.8±45.0 °C(Predicted)
• 密度：
  1.141±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(p-methoxyphenyl)-2-tetralone 在 Ru[(S,S)-Tsdpen](p-cymene) 甲酸 、 三乙胺 作用下， 反应 92.0h， 以88%的产率得到(1R,2S)-1-(p-methoxyphenyl)-2-hydroxy-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  Dynamic kinetic resolution–asymmetric transfer hydrogenation of 1-aryl-substituted cyclic ketones

  摘要：

  A range of 1-aryl-2-tetranols, and 1-phenyl-2-indanol, have been generated in high yield and enantiomeric excess from the corresponding racemic ketones, via a dynamic kinetic resolution-transfer hydrogenation process, using Ru(II)-TsDPEN in formic acid/triethylamine (5:2). This provides a potential entry to an asymmetric total synthesis of benzazepines such as Sch 39166. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00648-1
• 作为产物：
  描述：

  7b-(4-methoxyphenyl)-1a,2,3,7b-tetrahydro-1-oxacyclopropa[a ]naphthalene 在 zinc(II) iodide 作用下， 以 甲苯 为溶剂， 反应 1.0h， 生成 1-(p-methoxyphenyl)-2-tetralone
  参考文献：
  名称：

  Dynamic kinetic resolution–asymmetric transfer hydrogenation of 1-aryl-substituted cyclic ketones

  摘要：

  A range of 1-aryl-2-tetranols, and 1-phenyl-2-indanol, have been generated in high yield and enantiomeric excess from the corresponding racemic ketones, via a dynamic kinetic resolution-transfer hydrogenation process, using Ru(II)-TsDPEN in formic acid/triethylamine (5:2). This provides a potential entry to an asymmetric total synthesis of benzazepines such as Sch 39166. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00648-1

文献信息

• Methods for selectively synthesizing 1-aryl-2-tetralones
  申请人：Corning Incorporated

  公开号：US07829745B1

  公开（公告）日：2010-11-09

  Described herein are methods for synthesizing 1-aryl-2-tetralones in an efficient and highly selective manner. The reaction involves a one-step procedure for coupling an aryl halide to a 2-tetralone, where coupling occurs substantially at the 1-position of the 2-tetralone.

  本文描述了一种高效且高度选择性地合成1-芳基-2-四氢萘酮的方法。该反应涉及将芳基卤化物与2-四氢萘酮进行偶联的一步法程序，其中偶联主要发生在2-四氢萘酮的1位。
• Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one
  申请人：Takenaka Junji

  公开号：US20080200697A1

  公开（公告）日：2008-08-21

  1-aryl-3,4-dihydro-1H-naphthalene-2-one is prepared by isomerizing an epoxy compound represented by the following general formula, wherein a is an integer of 0 to 5, b is an integer of 0 to 4, and R 1 to R 6 are hydrogen atoms or substituents such as alkyl groups, in an organic solvent in the presence of magnesium sulfate. This process makes it possible to prepare the 1-aryl-3,4-dihydro-1H-naphthalene-2-one safely and in a high yield without using highly explosive compounds such as lithium perchlorate.

  1-芳基-3,4-二氢-1H-萘烯-2-酮是通过在有机溶剂中，在硫酸镁存在下，使下列一般式所表示的环氧化合物异构化而制备的，其中a是0至5的整数，b是0至4的整数，R1至R6是氢原子或如烷基等取代基。该过程使得能够在不使用高度爆炸性化合物（如过氯酸锂）的情况下，安全地高产率制备1-芳基-3,4-二氢-1H-萘烯-2-酮。
• A Pd‐Catalyzed Annulation Strategy to Linearly Fused Functionalized N‐Heterocycles
  作者：Larry Hoteite、Benjamin D. W. Allen、Ms. Ergaiya A. Elhajj、Anthony J. H. M. Meijer、Joseph P. A. Harrity

  DOI：10.1002/chem.202400116

  日期：2024.4.11

  annulation strategy to linearly fused polycyclic piperidines from readily available substrates. These products can be chemoselectively functionalized to generate analogs that represent common substructures in bioactive compounds.

  我们报告了一种从容易获得的底物中线性稠合多环哌啶的立体选择性钯催化成环策略。这些产品可以进行化学选择性功能化，以生成代表生物活性化合物中常见子结构的类似物。
• Process for the preparation of 1-aryl-3, 4-dihydro-1h-napthalene-2-one
  申请人：Tokuyama Corporation

  公开号：EP1955992B1

  公开（公告）日：2011-11-23
• METHODS FOR SELECTIVELY SYNTHESIZING 1-ARYL-2-TETRALONES
  申请人：Corning Incorporated

  公开号：EP2467202B1

  公开（公告）日：2017-04-19