4,6-二氯-2-苯基喹唑啉 | 54665-93-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 4,6-二氯-2-苯基喹唑啉
• 英文名称: 4,6-dichloro-2-phenyl-quinazoline
• 英文别名: 2-Phenyl-4,6-dichlorchinazolin；4,6-Dichloro-2-phenylquinazoline
• CAS: 54665-93-9
• 化学式: C₁₄H₈Cl₂N₂
• mdl: MFCD04115225
• 分子量: 275.137
• InChiKey: XALHJBONTKQNKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  4,6-二氯-2-苯基喹唑啉 在 sodium azide 作用下， 以 苯 为溶剂， 反应 5.0h， 以60%的产率得到8-Chloro-4-phenyl-1,2,3,3a,5-pentaaza-cyclopenta[a]naphthalene
  参考文献：
  名称：

  Synthesis of Some New Chloro Derivatives of Quinazolino[4,3-b]quinazolin-5-one and Tetrazolo[5,4-c]quinazoline

  摘要：

  将氯气引入生物多功能杂环环可能会提高它们的药理活性。因此，化合物IIa-IIr和IIIa-IIIf旨在结合杂环核的杀虫特性。

  DOI：

  10.1135/cccc19921559

文献信息

• Synthesis of Some New Chloro Derivatives of Quinazolino[4,3-b]quinazolin-5-one and Tetrazolo[5,4-c]quinazoline
  作者：Mohamed F. Abdel-Megeed、Salah M. Yassin、Mohamed A. Saleh

  DOI：10.1135/cccc19921559

  日期：——

  Introducing of chlorine into biologically versatile heterocyclic rings might led to the improvement of their pharmacological activity. Therefore compounds IIa-IIr and IIIa-IIIf were prepared with the aim to combine the pesticidal qualities of heterocyclic nuclei.

  将氯气引入生物多功能杂环环可能会提高它们的药理活性。因此，化合物IIa-IIr和IIIa-IIIf旨在结合杂环核的杀虫特性。
• Rho-kinase inhibitors
  申请人：Nagarathnam Dhanaphalan

  公开号：US20060142313A1

  公开（公告）日：2006-06-29

  Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

  本发明涉及化合物及其衍生物、其合成和作为Rho-激酶抑制剂的用途。本发明的这些化合物对于抑制肿瘤生长、治疗勃起功能障碍以及治疗其他由Rho-激酶介导的适应症（例如冠心病）非常有用。
• PROCESS FOR PREPARING QUINAZOLINE RHO-KINASE INHIBITORS AND INTERMEDIATES THEREOF
  申请人：BANKSTON Donald

  公开号：US20100125139A1

  公开（公告）日：2010-05-20

  A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.

  一种制备多种喹唑啉化合物的方法，这些化合物可用作Rho激酶抑制剂，因此在治疗高血压和其他适应症方面具有用途。
• RHO-KINASE INHIBITORS
  申请人：Nagarathnam Dhanaphalan

  公开号：US20100137324A1

  公开（公告）日：2010-06-03

  Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

  本发明揭示了化合物及其衍生物，它们的合成以及它们作为Rho-激酶抑制剂的用途。本发明的这些化合物对于抑制肿瘤生长、治疗勃起功能障碍以及治疗其他由Rho-激酶介导的适应症，例如冠心病，是有用的。
• Process for preparing quinazoline RHO-kinase inhibitors and intermediates thereof
  申请人：BAYER CORPORATION

  公开号：EP1953152A1

  公开（公告）日：2008-08-06

  The present invention relates to methods of producing quinazoline compounds and derivatives thereof which are useful as Rho-kinase Inhibitors or intermediates thereof. Rho-kinase inhibitors are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

  本发明涉及生产可用作Rho-激酶抑制剂或其中间体的喹唑啉化合物及其衍生物的方法。Rho-激酶抑制剂可用于抑制肿瘤生长、治疗勃起功能障碍和治疗由Rho-激酶介导的其他适应症，如冠心病。