N-2-丙基-(9ci)-2-氨基苯并噻唑 | 24622-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 中文名称: N-2-丙基-(9ci)-2-氨基苯并噻唑
• 英文名称: N-allyl-2-aminobenzo[d]thiazole
• 英文别名: N-allylbenzo[d]thiazol-2-amine；allyl-benzothiazol-2-yl-amine；Allyl-benzothiazol-2-yl-amin；2-Allylaminobenzthiazol；N-allyl-1,3-benzothiazol-2-amine；N-prop-2-enyl-1,3-benzothiazol-2-amine
• CAS: 24622-34-2
• 化学式: C₁₀H₁₀N₂S
• mdl: MFCD07344319
• 分子量: 190.269
• InChiKey: MRUBCUAZOZBUGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为产物：
  描述：

  N-allyl-N'-(2-amino-phenyl)-thiourea 在 盐酸 作用下， 生成 N-2-丙基-(9ci)-2-氨基苯并噻唑
  参考文献：
  名称：

  Ghosh; Guha, Journal of the Indian Chemical Society, 1929, vol. 6, p. 193

  摘要：

  DOI：

文献信息

• Novel Solid-Phase Parallel Synthesis of <i>N</i>-Substituted-2-aminobenzo [<i>d</i>]thiazole Derivatives via Cyclization Reactions of 2-Iodophenyl Thiourea Intermediate Resin
  作者：Seul-Gi Kim、Se-Lin Jung、Gee-Hyung Lee、Young-Dae Gong

  DOI：10.1021/co300112b

  日期：2013.1.14

  N-sulfonyl-2-aminobenzo[d]thiazole derivatives. The key step in this procedure involves the preparation of polymer-bound 2-aminobenzo[d]thiazole resins 5 by cyclization reaction of 2-iodophenyl thiourea resin 3. The resin-bound 2-iodophenyl thiourea 3 is produced by addition of 2-iodophenyl isothiocyanate 2 to the amine-terminated linker amide resin 1. These core skeleton 2-aminobenzo[d]thiazole resins 5 undergo

  已经开发了用于合成N-烷基，N-酰基和N-磺酰基-2-氨基苯并[ d ]噻唑衍生物的新型固相方法。该过程中的关键步骤涉及通过2-碘苯基硫脲树脂3的环化反应制备与聚合物结合的2-氨基苯并[ d ]噻唑树脂5。通过将2-碘苯基异硫氰酸酯2添加到胺封端的连接酰胺树脂1中来生产树脂结合的2-碘苯基硫脲3。这些核心骨架的2-氨基苯并[ d ]噻唑树脂5经历与各种亲电子，如烷基卤，酰基氯，和磺酰氯官能化反应以产生Ñ -烷基，Ñ -酰基，和Ñ磺酰基-2-氨基苯并[ d ]噻唑树脂6，7，和8，分别。最后，Ñ -烷基，Ñ -酰基，和Ñ磺酰基-2-氨基苯并[ d ]噻唑衍生物9，10，和11，然后在良好的产率和纯度通过各树脂的切割产生6，7，和8 在二氯甲烷（DCM）中使用三氟乙酸（TFA）。
• [EN] POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY<br/>[FR] COMPOSÉ POLYMÉRISABLE ET CORPS OPTIQUEMENT ANISOTROPE
  申请人：DAINIPPON INK & CHEMICALS

  公开号：WO2017079867A1

  公开（公告）日：2017-05-18

  There is provided a polymerizable composition, by which discoloration or alignment defects are less likely to occur when a filmy polymer, which is obtained by adding a polymerizable compound to the polymerizable composition and polymerizing this composition, is irradiated with ultraviolet light. There are also provided a polymer obtained by polymerizing the polymerizable composition, and an optically anisotropic body using the polymer. The present invention provides a polymerizable low-wavelength dispersive or polymerizable reverse-wavelength dispersive compound having a partial structure represented by Formula (Z-0). Further, the present invention provides a composition containing the compound; a polymer obtained by polymerizing the composition; and an optically anisotropic body obtained by using the polymer.

  提供一种可聚合的组合物，通过该组合物得到的薄膜聚合物在紫外光照射时，不太容易发生变色或排列缺陷。还提供了通过聚合该聚合物组合物得到的聚合物，以及使用该聚合物的光学各向异性体。本发明提供了一种具有由式（Z-0）表示的部分结构的可聚合低波长色散或可聚合反波长色散化合物。此外，本发明提供了一种含有该化合物的组合物；通过聚合该组合物得到的聚合物；以及通过使用该聚合物得到的光学各向异性体。
• Control of selectivity in the preparation of 2-substituted benzoazoles by adjusting the surface hydrophobicity in two solid-based sulfonic acid catalysts
  作者：Babak Karimi、Akbar Mobaraki、Hamid M. Mirzaei、Hojatollah Vali

  DOI：10.1039/d2ob02274e

  日期：——

  A series of metal-free tandem reactions for the synthesis of pharmaceutically important 2-substituted benzoazoles from isothiocyanates and 2-aminothiophenol under catalyst-free conditions in the presence of Et-PMO-Me-PrSO3H (1a) and SBA-15-PrSO3H (1b) as solid acids were carried out in a highly selective way under solvent free conditions. A significant selectivity changeover toward either 2-mercaptobenzoxazole

  在 Et-PMO-Me-PrSO 3 H ( 1a ) 和 SBA-15-存在下，在无催化剂条件下，从异硫氰酸酯和 2-氨基苯硫酚合成药学上重要的 2-取代苯并唑的一系列无金属串联反应PrSO 3 H ( 1b ) 作为固体酸在无溶剂条件下以高度选择性的方式进行。通过将使用的催化剂从相对疏水的材料1a改为更亲水的催化剂1b，可以实现对 2-巯基苯并恶唑或 2-氨基苯并唑衍生物的显着选择性转换. 这种简单的实验程序采用新颖的苯并唑选择性方法，并辅以绿色和可重复使用的催化剂，可被视为现有 2-取代苯并唑衍生物合成方法的替代方法。
• Radiolabelled alkylamino-benzothiazole and -benzoxazole derivatives and their use as D4 ligands
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1325917A1

  公开（公告）日：2003-07-09

  The present invention concerns the radiolabelled compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is O or S; n is 2, 3, 4 or 5; R1 is hydrogen, C1-6alkyl, C1-6alkyloxy or halo; R2 is hydrogen, C1-6alkyl, phenyl, phenylC1-6alkyl or phenylcarbonyl; R3 and R4 each independently are selected from hydrogen, halo, nitro, C1-6alkyl, C1-6alkyloxy, haloC1-6alkyl, aminosulfonyl, mono- or di(C1-4alkyl)aminosulfonyl; or R3 and R4 may also be taken together to form a bivalent radical of formula -CH=CH-CH=CH- , characterized in that the compound has at least one halo which is a radioactive isotope of iodine, bromine or fluorine, or has at least one 11C-atom or tritium atom ; it further relates to a process of marking dopamine D4 receptor sites and a process for imaging an organ.

  本发明涉及放射性标记的式化合物 其中X为O或S；n为2、3、4或5；R1为氢、C1-6烷基、C1-6烷氧基或卤代；R2 是氢、C1-6烷基、苯基、苯基 C1-6 烷基或苯基羰基； R3 和 R4 各自独立地选自氢、卤素、硝基、C1-6烷基、C1-6烷氧基、卤代 C1-6 烷基、氨磺酰基、单-或二(C1-4烷基)氨磺酰基；或 R3 和 R4 也可以结合在一起形成式-CH=CH-CH=CH-的二价基，其特征在于该化合物具有至少一个卤素，该卤素是碘、溴或氟的放射性同位素，或具有至少一个 11C 原子或氚原子；它还涉及一种标记多巴胺 D4 受体位点的工艺和一种器官成像工艺。
• Laccase-Catalysed Homocoupling of Primary Aromatic Amines towards the Biosynthesis of Dyes
  作者：Ana Catarina Sousa、Lígia O. Martins、M. Paula Robalo

  DOI：10.1002/adsc.201300501

  日期：2013.10.11

  AbstractColoured disubstituted benzoquinonimine trimeric structures are obtained as main reaction products of the oxidation of p‐electron donor primary aromatic amines using two different laccases, CotA‐laccase from Baccilus subtilus and TvL from Trametes versicolor. These orange‐red to purple products, presenting high molar extinction coefficients, presumably result from oxidative homocoupling reactions, through the formation of NC bonds at positions 2 and 5, of the laccase oxidised intermediate as showed in the proposed oxidative pathway. The product of 1,4‐phenylenediamine is shown to be the trimer known as Bandrowski’s base which has an established role in hair and fur dyeing. Our results also show that the occurrence and/or rates of oxidation of aromatic amines are strongly dependent on the presence of p‐electron releasing substituents in the aromatic ring and are independent on the properties of the enzyme used. Overall our data contribute for (i) understanding key features of laccase reactivity with p‐substituted aromatic amines and (ii) establishing enzymatic processes that lead to the synthesis of coloured bio‐products under mild conditions with potential impact in the cosmetic and dye industries.magnified image