N-Ethyliden-1,1-dipropyl-butylamin | 64467-60-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-Ethyliden-1,1-dipropyl-butylamin
• 英文别名: N-Ethylidene-4-propyl-4-heptanamine；N-(4-propylheptan-4-yl)ethanimine
• CAS: 64467-60-3
• 化学式: C₁₂H₂₅N
• 分子量: 183.337
• InChiKey: AOSWAYINXPKDRV-UHFFFAOYSA-N

物化性质

• 沸点：
  252.9±13.0 °C(Predicted)
• 密度：
  0.78±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-Ethyliden-1,1-dipropyl-butylamin 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 N-ethyl-1,1-di-n-propyl-n-butylamine
  参考文献：
  名称：

  Pigerol; Vernieres; Broll, European Journal of Medicinal Chemistry, 1977, vol. 12, # 4, p. 351 - 359

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1-二丙基丁基异氰酸酯 在 盐酸 、 氢氧化钾 作用下， 生成 N-Ethyliden-1,1-dipropyl-butylamin
  参考文献：
  名称：

  Pigerol; Vernieres; Broll, European Journal of Medicinal Chemistry, 1977, vol. 12, # 4, p. 351 - 359

  摘要：

  DOI：

文献信息

• Secondary amines
  申请人：Labaz

  公开号：US04201725A1

  公开（公告）日：1980-05-06

  Methylamine derivatives of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.3 each represent a hydrogen atom or a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 6 carbon atoms, R.sub.2 represents a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 2 to 7 carbon atoms with the proviso that when R.sub.2 represents an alkenyl radical of the formula CH.dbd.CH--R.sub.6 or an alkynyl radical of the formula C.tbd.C--R.sub.6, in which R.sub.6 represents a hydrogen atom or a straight- or branched-chain alkyl radical of 1 to 5 carbon atoms, R.sub.1 and R.sub.3 each represent an atom of hydrogen or an alkyl radical, R.sub.4 and R.sub.5, which are the same or different, each respresent a hydrogen atom, a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 5 carbon atoms or an .omega.-hydroxyalkyl radical containing from 2 to 5 carbon atoms or R.sub.4 and R.sub.5, when they are taken together represent an alkylene radical containing from 2 to 6 carbon atoms, an alkylidene radical containing from 1 to 5 carbon atoms or the radical --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --CH.sub.2 --, R.sub.1, R.sub.2 and R.sub.3 being such that the trisubstituted methylamine radical possesses no more than 13 carbon atoms. They are useful for treating Parkinson's disease and for correcting extra-pyramidal disturbances provoked by neuroleptics.

  化合物的甲基胺衍生物的公式：##STR1##及其药学上可接受的酸加成盐，其中R.sub.1和R.sub.3分别代表氢原子或含有1至6个碳原子的直链或支链烷基，烯基或炔基基团，R.sub.2代表含有2至7个碳原子的直链或支链烷基，烯基或炔基基团，但当R.sub.2代表公式CH.dbd.CH--R.sub.6的烯基基团或公式C.tbd.C--R.sub.6的炔基基团，其中R.sub.6代表氢原子或含有1至5个碳原子的直链或支链烷基基团时，R.sub.1和R.sub.3分别代表氢原子或烷基基团，R.sub.4和R.sub.5相同或不同，每个都代表氢原子，含有1至5个碳原子的直链或支链烷基，烯基或炔基基团，或者含有2至5个碳原子的ω-羟基烷基基团，或当它们一起取代时，代表含有2至6个碳原子的烷基基团，含有1至5个碳原子的烷基基团或基团--CH.sub.2--CH.sub.2--O--CH.sub.2--CH.sub.2--，其中R.sub.1，R.sub.2和R.sub.3使三取代甲基胺基团不超过13个碳原子。它们可用于治疗帕金森病和纠正由神经精神药物引起的额外锥体外运动障碍。
• Active derivatives of methylamine in therapeutic compositions and
  申请人：Labaz

  公开号：US04057644A1

  公开（公告）日：1977-11-08

  Methylamine derivatives of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.3 each represent a hydrogen atom or a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 6 carbon atoms, R.sub.2 represents a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 2 to 7 carbon atoms with the proviso that when R.sub.2 represents an alkenyl radical of the formula CH.dbd.CH--R.sub.6 or an alkynyl radical of the formula C.tbd.C--R.sub.6, in which R.sub.6 represents a hydrogen atom or a straight- or branched-chain alkyl radical of 1 to 5 carbon atoms, R.sub.1 and R.sub.3 each represent an atom of hydrogen or an alkyl radical, R.sub.4 and R.sub.5, which are the same or different, each represent a hydrogen atom, a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 5 carbon atoms or an .omega.-hydroxyalkyl radical containing from 2 to 5 carbon atoms or R.sub.4 and R.sub.5, when they are taken together represent an alkylene radical containing from 2 to 6 carbon atoms, an alkylidene radical containing from 1 to 5 carbon atoms or the radical --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --CH.sub.2 --, R.sub.1, R.sub.2 and R.sub.3 being such that the trisubstituted methylamine radical possesses no more than 13 carbon atoms. They are useful for treating Parkinson's disease and for correcting extra-pyramidal disturbances provoked by neuroleptics.

  该文描述了公式为##STR1##的甲基胺衍生物及其药学上可接受的酸盐，其中R.sub.1和R.sub.3分别代表氢原子或含有1至6个碳原子的直链或支链烷基，烯基或炔基基团，R.sub.2代表含有2至7个碳原子的直链或支链烷基，烯基或炔基基团，但当R.sub.2表示公式CH.dbd.CH--R.sub.6的烯基基团或公式C.tbd.C--R.sub.6的炔基基团，其中R.sub.6表示1至5个碳原子的氢原子或直链或支链烷基基团时，R.sub.1和R.sub.3分别表示氢原子或烷基基团，R.sub.4和R.sub.5相同或不同，分别表示氢原子，含有1至5个碳原子的直链或支链烷基，烯基或炔基基团或含有2至5个碳原子的ω-羟基烷基基团，或当它们一起取代时，表示含有2至6个碳原子的烷基基团，含有1至5个碳原子的烷基亚甲基基团或基团--CH.sub.2--CH.sub.2--O--CH.sub.2--CH.sub.2--，其中R.sub.1，R.sub.2和R.sub.3使三取代甲基胺基团不超过13个碳原子。它们可用于治疗帕金森病和纠正由神经病药物引起的额外锥体外运动障碍。
• Pigerol; Vernieres; Broll, European Journal of Medicinal Chemistry, 1977, vol. 12, # 4, p. 351 - 359
  作者：Pigerol、Vernieres、Broll、et al.

  DOI：——

  日期：——