2-(pivaloylamino)-4(3H)-oxo-6-bromo-7-(ethoxycarbonyl)-7H-pyrrolo<2,3-d>pyrimidine | 173850-15-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 2-(pivaloylamino)-4(3H)-oxo-6-bromo-7-(ethoxycarbonyl)-7H-pyrrolo<2,3-d>pyrimidine
• 英文别名: ethyl 6-bromo-2-(2,2-dimethylpropanoylamino)-4-oxo-3H-pyrrolo[2,3-d]pyrimidine-7-carboxylate
• CAS: 173850-15-2
• 化学式: C₁₄H₁₇BrN₄O₄
• 分子量: 385.217
• InChiKey: MIVNXRZKPXYJLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(pivaloylamino)-4(3H)-oxo-6-bromo-7-(ethoxycarbonyl)-7H-pyrrolo<2,3-d>pyrimidine 在 palladium on activated charcoal sodium hydroxide 、 copper(l) iodide 、 四(三苯基膦)钯 、 氢气 、 三乙胺 作用下， 以 甲醇 、 乙腈 为溶剂， 25.0~50.0 ℃ 、344.73 kPa 条件下， 反应 53.25h， 生成 N-{4-[2-(2-amino-5,6-dihydro-4(3H)-oxo-7H-pyrrolo[2,3-d]-pyrimidin-6-yl)ethyl] benzoyl}-L-glutamic acid
  参考文献：
  名称：

  Synthesis of N-{4-[2-(2-Amino-5,6-dihydro-4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)- ethyl]benzoyl}-l-glutamic Acid:  A Ring-Contracted Analogue of 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid

  摘要：

  This paper describes the synthesis of N-(4-[2-(2-amino-5,6-dihydro-4(3H)-oxo-7H-pyrrolo[2,3-d]-pyrimidin-6-yl)ethyl]benzoyl) -L-glutamic acid (4), which can be viewed as a ring-contracted analogue of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF, 1) in which the C-7 methylene group of the latter has been excised and C-6 joined to N-8. This compound exhibits significant activity as an inhibitor of the growth of human (CCRF-CEM) lymphoblastic leukemic cells in vitro and apparently acts by blocking de novo purine biosynthesis through inhibition of glycinamide ribonucleotide formyltransferase (GAR FTase).

  DOI：

  10.1021/jo951471k
• 作为产物：
  描述：

  2-(pivaloylamino)-4(3H)-oxo-7-(ethoxycarbonyl)-7H-pyrrolo<2,3-d>pyrimidine 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以50%的产率得到2-(pivaloylamino)-4(3H)-oxo-6-bromo-7-(ethoxycarbonyl)-7H-pyrrolo<2,3-d>pyrimidine
  参考文献：
  名称：

  Synthesis of N-{4-[2-(2-Amino-5,6-dihydro-4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)- ethyl]benzoyl}-l-glutamic Acid:  A Ring-Contracted Analogue of 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid

  摘要：

  This paper describes the synthesis of N-(4-[2-(2-amino-5,6-dihydro-4(3H)-oxo-7H-pyrrolo[2,3-d]-pyrimidin-6-yl)ethyl]benzoyl) -L-glutamic acid (4), which can be viewed as a ring-contracted analogue of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF, 1) in which the C-7 methylene group of the latter has been excised and C-6 joined to N-8. This compound exhibits significant activity as an inhibitor of the growth of human (CCRF-CEM) lymphoblastic leukemic cells in vitro and apparently acts by blocking de novo purine biosynthesis through inhibition of glycinamide ribonucleotide formyltransferase (GAR FTase).

  DOI：

  10.1021/jo951471k

文献信息

• Synthesis of <i>N</i>-{4-[2-(2-Amino-5,6-dihydro-4(3<i>H</i>)-oxo-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-6-yl)- ethyl]benzoyl}-<scp>l</scp>-glutamic Acid:  A Ring-Contracted Analogue of 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid
  作者：Edward C. Taylor、Wendy B. Young、Carsten Spanka

  DOI：10.1021/jo951471k

  日期：1996.1.1

  This paper describes the synthesis of N-(4-[2-(2-amino-5,6-dihydro-4(3H)-oxo-7H-pyrrolo[2,3-d]-pyrimidin-6-yl)ethyl]benzoyl) -L-glutamic acid (4), which can be viewed as a ring-contracted analogue of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF, 1) in which the C-7 methylene group of the latter has been excised and C-6 joined to N-8. This compound exhibits significant activity as an inhibitor of the growth of human (CCRF-CEM) lymphoblastic leukemic cells in vitro and apparently acts by blocking de novo purine biosynthesis through inhibition of glycinamide ribonucleotide formyltransferase (GAR FTase).