1-(3-Chlorophenyl)-2-(3,4-dichlorophenyl)ethanone | 1196493-36-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(3-Chlorophenyl)-2-(3,4-dichlorophenyl)ethanone
• CAS: 1196493-36-3
• 化学式: C₁₄H₉Cl₃O
• 分子量: 299.584
• InChiKey: DREHZNPYXUJGMY-UHFFFAOYSA-N

物化性质

• 沸点：
  419.6±40.0 °C(Predicted)
• 密度：
  1.377±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  tris(3-chlorophenyl)bismuthane 、 2',3',4'-三氯苯乙酮 在 bis-triphenylphosphine-palladium(II) chloride 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以68%的产率得到1-(3-Chlorophenyl)-2-(3,4-dichlorophenyl)ethanone
  参考文献：
  名称：

  Pd-catalyzed synthesis of α-aryl ketones through couplings of α-arylacetyl chlorides with triarylbismuths as multi-coupling nucleophiles

  摘要：

  The cross-coupling reaction of alpha-arylacetyl chlorides with triarylbismuths was studied under Pd-catalyzed conditions. The reaction was found to be facile under the established protocol and furnished high yields of alpha-aryl ketones in short reaction times. This work also demonstrated a facile synthesis of various regio-isomeric mono-, di- and tri-substituted alpha-aryl ketones in high yields. Triarylbisrnuths were employed as sub-stoichiometric multi-coupling organometallic nucleophiles in this coupling protocol. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.074

文献信息

• Pd-catalyzed synthesis of α-aryl ketones through couplings of α-arylacetyl chlorides with triarylbismuths as multi-coupling nucleophiles
  作者：Maddali L.N. Rao、Somnath Giri、Deepak N. Jadhav

  DOI：10.1016/j.tetlet.2009.08.074

  日期：2009.11

  The cross-coupling reaction of alpha-arylacetyl chlorides with triarylbismuths was studied under Pd-catalyzed conditions. The reaction was found to be facile under the established protocol and furnished high yields of alpha-aryl ketones in short reaction times. This work also demonstrated a facile synthesis of various regio-isomeric mono-, di- and tri-substituted alpha-aryl ketones in high yields. Triarylbisrnuths were employed as sub-stoichiometric multi-coupling organometallic nucleophiles in this coupling protocol. (C) 2009 Elsevier Ltd. All rights reserved.