代谢
Metabolic studies were performed in rats using single low and single high doses of radiolabeled thiodicarb. The major routes of elimination were expiration (CO2 and acetonitrile) and urination. Tissue residues contained 7-9% of the dose at 7 days post dose and may reflect the metabolism of (14)C-acetonitrile into the body's C-2 and C-1 pools and subsequent interaction with, or incorporation into natural products. The major terminal metabolites of thiodicarb in the rat are CO2 and acetonitrile. The major urinary metabolite is a labile unknown that represents 50% of the urinary radiolabel. No acetamide was detected in any of the tissues. The RBCs contained only residue that cannot be extracted by organic solvents or water, indicating the presence of radiolabel incorporated into natural products or of material tightly bound to hemoglobin.
在老鼠身上使用单次低剂量和单次高剂量的放射性标记的硫代碳酸进行了代谢研究。消除的主要途径是呼出（二氧化碳和丙酮）和排尿。在给药后7天，组织残留物中含有7-9%的剂量，这可能反映了(14)C-丙酮转化为体内的C-2和C-1池，随后与天然产物相互作用或结合。老鼠体内硫代碳酸的主要终末代谢物是二氧化碳和丙酮。主要的尿液代谢物是一种不稳定的未知物质，占尿液放射性标记的50%。在任何组织中都没有检测到乙酰胺。红细胞中只含有不能被有机溶剂或水提取的残留物，这表明放射性标记已经结合到天然产物中，或者是紧密地结合到血红蛋白上的物质。
Metabolic studies were performed in rats using single low and single high doses of radiolabeled thiodicarb. The major routes of elimination were expiration (CO2 and acetonitrile) and urination. Tissue residues contained 7-9% of the dose at 7 days post dose and may reflect the metabolism of (14)C-acetonitrile into the body's C-2 and C-1 pools and subsequent interaction with, or incorporation into natural products. The major terminal metabolites of thiodicarb in the rat are CO2 and acetonitrile. The major urinary metabolite is a labile unknown that represents 50% of the urinary radiolabel. No acetamide was detected in any of the tissues. The RBCs contained only residue that cannot be extracted by organic solvents or water, indicating the presence of radiolabel incorporated into natural products or of material tightly bound to hemoglobin.
来源:Hazardous Substances Data Bank (HSDB)
