5-[Tert-butyl(dimethyl)silyl]oxy-2,2-dimethyl-1,3-benzodioxin-4-one | 888958-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 5-[Tert-butyl(dimethyl)silyl]oxy-2,2-dimethyl-1,3-benzodioxin-4-one
• CAS: 888958-29-0
• 化学式: C₁₆H₂₄O₄Si
• 分子量: 308.45
• InChiKey: AFKMYRMZYXNPLY-UHFFFAOYSA-N

物化性质

• 沸点：
  381.7±42.0 °C(Predicted)
• 密度：
  1.043±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.36
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-[Tert-butyl(dimethyl)silyl]oxy-2,2-dimethyl-1,3-benzodioxin-4-one 在 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 2,6-二羟基苯甲醛
  参考文献：
  名称：

  Efficient and Selective Reduction Protocols of the 2,2-Dimethyl-1,3-benzodioxan-4-one Functional Group to Readily Provide Both Substituted Salicylaldehydes and 2-Hydroxybenzyl Alcohols

  摘要：

  Two complementary procedures have been developed that selectively allow for the synthesis of either substituted salicylaldehydes or the corresponding 2-hydroxylbenzyl alcohols upon treatment of the 2,2-dimethyl- 1,3-benzodioxan-4-one functional group with DIBAL-H or LAH, respectively.

  DOI：

  10.1021/jo0601664
• 作为产物：
  描述：

  、 丙酮 在 三氟乙酸 、 三氟乙酸酐 作用下， 反应 48.0h， 生成 5-[Tert-butyl(dimethyl)silyl]oxy-2,2-dimethyl-1,3-benzodioxin-4-one
  参考文献：
  名称：

  Efficient and Selective Reduction Protocols of the 2,2-Dimethyl-1,3-benzodioxan-4-one Functional Group to Readily Provide Both Substituted Salicylaldehydes and 2-Hydroxybenzyl Alcohols

  摘要：

  Two complementary procedures have been developed that selectively allow for the synthesis of either substituted salicylaldehydes or the corresponding 2-hydroxylbenzyl alcohols upon treatment of the 2,2-dimethyl- 1,3-benzodioxan-4-one functional group with DIBAL-H or LAH, respectively.

  DOI：

  10.1021/jo0601664

文献信息

• Efficient and Selective Reduction Protocols of the 2,2-Dimethyl-1,3-benzodioxan-4-one Functional Group to Readily Provide Both Substituted Salicylaldehydes and 2-Hydroxybenzyl Alcohols
  作者：Naval Bajwa、Michael P. Jennings

  DOI：10.1021/jo0601664

  日期：2006.4.1

  Two complementary procedures have been developed that selectively allow for the synthesis of either substituted salicylaldehydes or the corresponding 2-hydroxylbenzyl alcohols upon treatment of the 2,2-dimethyl- 1,3-benzodioxan-4-one functional group with DIBAL-H or LAH, respectively.