2-(pyridin-2-yl)-6,7-diphenyl-1H-imidazo[4,5-g]quinoxaline | 1354638-95-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(pyridin-2-yl)-6,7-diphenyl-1H-imidazo[4,5-g]quinoxaline
• CAS: 1354638-95-1
• 化学式: C₂₆H₁₇N₅
• 分子量: 399.454
• InChiKey: CCSGBMOOPWRXPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  31.0
• 可旋转键数：
  3.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.35
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  N,N'-(4,5-二硝基-1,2-亚苯基)双(4-甲基苯磺酰胺) 在 硫酸 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 30.0h， 生成 2-(pyridin-2-yl)-6,7-diphenyl-1H-imidazo[4,5-g]quinoxaline
  参考文献：
  名称：

  Synthesis, DNA-binding, and photocleavage studies of ruthenium(II) complexes with an asymmetric ligand

  摘要：

  An asymmetric ligand (pdpiq = 2-(pyridine-2-yl)-6,7-diphenyl-l-H-imidazo[4,5-g]quinoxaline) and its ruthenium complexes with [Ru(L)(2)pdpiq](2+) (L = bpy (2,2'-bipyridine) or phen (1,10-phenanthroline)) have been synthesized and characterized by elemental analysis, ES-MS, and H-1 NMR. The DNA-binding behaviors of these complexes were studied by spectroscopic methods and viscosity measurements. The results indicate that the complexes can intercalate into DNA base pairs. When irradiated at 365 nm, the two complexes promote the cleavage of plasmid pBR322DNA. The mechanism of DNA cleavage is an oxidative process by generating singlet oxygen.

  DOI：

  10.1080/00958972.2011.639364