N-甲基-5-苯基戊-1-胺 | 4266-02-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-甲基-5-苯基戊-1-胺
• 英文名称: N-methyl-5-phenylpentylamine
• 英文别名: N-methyl-5-phenylpentan-1-amine；N-methyl-N-(5-phenylpentyl)amine；5-Phenylpentylmethylamine
• CAS: 4266-02-8
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: HLZWAUHPNKCBEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921499090

反应信息

• 作为反应物：
  描述：

  N-甲基-5-苯基戊-1-胺 生成 5-methylamino-1-phenyl-pentan-1-ol
  参考文献：
  名称：

  The Influence of Solvent and Chloramine Structure on the Free-Radical Rearrangement Products of N-Chlorodialkylamines

  摘要：

  DOI：

  10.1021/jo01022a022
• 作为产物：
  描述：

  2-Methyl-1,3,4,5,6,11a-hexahydro-2H-2-benzazonine 在 盐酸 作用下， 反应 2.0h， 以76%的产率得到N-甲基-5-苯基戊-1-胺
  参考文献：
  名称：

  Rearrangement of 1-methyl-2-(substituted-phenyl)piperidinium 1-methylides in a neutral medium

  摘要：

  DOI：

  10.1021/jo00265a022

文献信息

• Phenylaliphatylaminoalkanediphosphonic acids
  申请人：Ciba-Geigy Corporation

  公开号：US05162310A1

  公开（公告）日：1992-11-10

  Phenylaliphatylaminoalkanediphosphonic acids of the formula ##STR1## in which R.sub.1 is an aliphatic hydrocarbon radical having 4 and not more than 7 C atoms and substituted by phenyl, R.sub.2 is a monovalent aliphatic hydrocarbon radical having 1 and not more than 4 C atoms and alk is a divalent aliphatic hydrocarbon radical having 2 and not more than 4 C atoms, and their salts, have a particularly pronounced regulating action on calcium metabolism and can be used as medicaments for the treatment of diseases to be attributed to disturbances thereof. They are prepared, for example, for reacting a compound of the formula ##STR2## in which X.sub.3 denotes carboxyl, with a phosphorylating agent and hydrolyzing the primary product.

  Phenylaliphatylaminoalkanediphosphonic acids的中文翻译为：苯基脂肪基氨基烷二膦酸。其中R.sub.1是一个具有4个至7个碳原子的脂肪烃基，被苯基取代，R.sub.2是一个具有1个至4个碳原子的一价脂肪烃基，alk是一个具有2个至4个碳原子的二价脂肪烃基，它们的盐对钙代谢具有特别显著的调节作用，并可用作治疗与其紊乱有关的疾病的药物。例如，它们可通过将具有以下结构的化合物与磷酸化剂反应并水解初级产物来制备：其中X.sub.3表示羧基。
• A General Acid‐Mediated Hydroaminomethylation of Unactivated Alkenes and Alkynes
  作者：Daniel Kaiser、Veronica Tona、Carlos R. Gonçalves、Saad Shaaban、Alberto Oppedisano、Nuno Maulide

  DOI：10.1002/anie.201906910

  日期：2019.10.7

  its considerable potential to streamline amine synthesis. State-of-the-art protocols for hydroaminomethylation of alkenes rely largely on transition-metal catalysis, enabling this transformation only under highly designed and controlled conditions. Here we report a broadly applicable, acid-mediated approach to the hydroaminomethylation of unactivated alkenes and alkynes. This methodology employs cheap

  与广泛研究的金属催化加氢胺化反应相比，加氢氨甲基化尽管具有极大的简化胺合成的潜力，但受到的关注却很少。烯烃加氢氨基甲基化的最新方案主要依赖于过渡金属催化，只有在高度设计和控制的条件下才能进行这种转化。在这里，我们报告了一种广泛适用的酸介导的方法，用于未活化的烯烃和炔烃的氢氨基甲基化。该方法采用廉价，易于获得且稳定的反应物，并提供所需的胺，且具有出色的官能团耐受性和无可挑剔的区域选择性。报道了这种转变的广泛范围，以及机理研究和原位多米诺骨牌功能化反应。
• Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective σ1 ligands. Part 2
  作者：Amaury Cazenave Gassiot、Julie Charton、Sophie Girault-Mizzi、Pauline Gilleron、Marie-Ange Debreu-Fontaine、Christian Sergheraert、Patricia Melnyk

  DOI：10.1016/j.bmcl.2005.07.039

  日期：2005.11

  Herein is described a new class of selective sigma1 ligands consisting of tetrahydroisoquinoline-hydantoin (Tic-hydantoin) derivatives. Compound 1a has high affinity (IC50 = 16 nM) for sigma1 receptor and is selective in a large panel of therapeutic targets. This study presents structural changes on the side chain of the Tic-hydantoin core. Analogs of higher affinity could be identified (IC50 approximately

  本文描述了由四氢异喹啉-乙内酰脲（Tic-乙内酰脲）衍生物组成的一类新的选择性sigma1配体。化合物1a对sigma1受体具有高亲和力（IC50 = 16 nM），并且在许多治疗靶标中具有选择性。这项研究提出了tic乙内酰脲核心的侧链上的结构变化。可以鉴定出具有更高亲和力的类似物（IC50约为2-3 nM）。
• Imidazole compounds
  申请人：——

  公开号：US20020058659A1

  公开（公告）日：2002-05-16

  A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

  一种新型的咪唑杂环化合物类，包括它们的药物组合物以及在治疗和/或预防与组织胺H3受体相关的疾病和疾病的用途。更具体地说，这些化合物对于治疗和/或预防与组织胺H3受体相互作用有益的疾病和疾病是有用的。
• Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
  申请人：3-Dimensional Pharmaceuticals, Inc.

  公开号：US20030105111A1

  公开（公告）日：2003-06-05

  The present invention is directed to a compound of Formula I: 1 wherein A, R 1 , and R 2 are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.

  本发明涉及一种具有以下结构的化合物：其中A、R1和R2在此处被定义。本发明还涉及包含Formula I化合物的组合物、使用Formula I化合物的方法以及制备Formula I化合物的方法。