N,N-双(2-氯乙基)-3-甲基苯胺 | 1204-57-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N,N-双(2-氯乙基)-3-甲基苯胺
• 英文名称: N,N-Bis-<2-chlor-aethyl>-3-methyl-anilin
• 英文别名: N,N-bis-(2-chloro-ethyl)-m-toluidine；N,N-Bis-(2-chlor-aethyl)-m-toluidin；N,N-bis(2-chloroethyl)-3-methylaniline
• CAS: 1204-57-5
• 化学式: C₁₁H₁₅Cl₂N
• mdl: MFCD01027191
• 分子量: 232.153
• InChiKey: WVZOGRZYBUCDOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2921430090

反应信息

• 作为反应物：
  描述：

  N,N-双(2-氯乙基)-3-甲基苯胺 在 sodium sulfide 、 丙酮 作用下， 生成 4-m-tolyl-thiomorpholine
  参考文献：
  名称：

  162.芳基-2-卤代烷基胺。第六部分 与某些有机硫化合物的反应

  摘要：

  DOI：

  10.1039/jr9500000815
• 作为产物：
  描述：

  N,N-双(2-羟基乙基)-间甲苯胺 在 三氯氧磷 作用下， 反应 0.5h， 生成 N,N-双(2-氯乙基)-3-甲基苯胺
  参考文献：
  名称：

  Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines

  摘要：

  A series of aniline mustards with a wide range of electron-donating and -withdrawing substituents in the 3- and 4-positions has been synthesized and evaluated for cytotoxicity in cell culture to examine the potential of using nitro group deactivated nitrogen mustards for the design of novel hypoxia-selective anticancer drugs (Denny, W. A.; Wilson, W. R. J. Med. Chem. 1986, 29, 879). Hydrolytic half-lives in tissue culture media, determined by bioassay against a cell line (UV4) defective in the repair of DNA interstrand cross-links showed the expected dependence on the Hammett electronic parameter, sigma, varying from 0.13 h for the 4-amino analogue to greater than 100 h for analogues with strongly electron-withdrawing substituents. Cytotoxic potencies in aerobic UV4 cultures showed a similar dependence on sigma. This dependence predicted that the 4-nitroaniline mustard would be 7200-fold less potent than its potential six-electron reduction product, the 4-amino compound, in growth inhibition assays using a 1-h drug exposure. The measured differential was much lower (225-fold) because of the instability of the latter compound, but a differential of 17,500-fold was observed in the initial rate of killing by using a clonogenic assay. The potential for formation of reactive mustards by reduction to the amine or hydroxylamine was demonstrated by the 4-nitroso compound, which had an aerobic toxicity similar to that of the amine. Although these features confirmed the original rationale, the 3-nitro- and 4-nitroaniline mustards had only minimal hypoxic selectivity against UV cells. Toxicity to hypoxic cells appears to be limited by the low reduction potentials of these compounds and consequent lack of enzymatic nitroreduction. However, this study has demonstrated that nitro groups can be used to latentiate aromatic nitrogen mustards and indicates that examples with higher reduction potentials could provide useful hypoxia-selective therapeutic agents.

  DOI：

  10.1021/jm00163a019

文献信息

• 43. Aryl-2-halogenoalkylamines. Part I
  作者：W. C. J. Ross

  DOI：10.1039/jr9490000183

  日期：——
• 276. Aryl-2-halogenoalkylamines. Part XVI. The preparation of derivatives of 4-[di-(2-chloroalkyl)amino]azobenzenes
  作者：W. C. J. Ross、G. P. Warwick

  DOI：10.1039/jr9560001364

  日期：——
• Ross et al., Journal of the Chemical Society, 1955, p. 3110,3115
  作者：Ross et al.

  DOI：——

  日期：——
• DE964290
  申请人：——

  公开号：——

  公开（公告）日：——
• US3930671A
  申请人：——

  公开号：US3930671A

  公开（公告）日：1976-01-06