3,5,7-trimethyl-1-adamantanecarbonitrile | 101901-51-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3,5,7-trimethyl-1-adamantanecarbonitrile
• 英文别名: 3,5,7-Trimethyltricyclo[3.3.1.13,7]decane-1-carbonitrile；3,5,7-trimethyladamantane-1-carbonitrile
• CAS: 101901-51-3
• 化学式: C₁₄H₂₁N
• 分子量: 203.327
• InChiKey: QWUFZARELIXRCR-UHFFFAOYSA-N

物化性质

• 熔点：
  75-76 °C
• 沸点：
  279.1±9.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,5,7-trimethyl-1-adamantanecarbonitrile 以98%的产率得到3,5,7-Trimethyl-1-adamantanecarboximidamide hydrochloride
  参考文献：
  名称：

  1-(adamantyl)amidines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission

  摘要：

  1-(戊二醇基)胺基甲酸盐类化合物及其在治疗通常与谷氨酸能传递异常相关的疾病中的用途。

  公开号：

  US06500866B1
• 作为产物：
  描述：

  3,5,7-三甲基金刚烷-1-羧酸 以88%的产率得到3,5,7-trimethyl-1-adamantanecarbonitrile
  参考文献：
  名称：

  1-(adamantyl)amidines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission

  摘要：

  1-(戊二醇基)胺基甲酸盐类化合物及其在治疗通常与谷氨酸能传递异常相关的疾病中的用途。

  公开号：

  US06500866B1

文献信息

• Selective Phthalimido-N-oxyl (PINO)-Catalyzed C–H Cyanation of Adamantane Derivatives
  作者：Jan-Philipp Berndt、Frederik Erb、Lukas Ochmann、Jaqueline Beppler、Peter Schreiner

  DOI：10.1055/s-0037-1610403

  日期：2019.3

  present a new method for the selective C(sp3)–H cyanation of adamantane derivatives with PINO as the hydrogen abstracting reagent. A cyano radical is thereby transferred from p -toluenesulfonyl cyanide, allowing the cyanation of adamantane derivatives in up to 71% yield. The protocol presents a novel way to orthogonally functionalized adamantanes that are otherwise difficult to prepare. Mechanistic studies

  我们提出了一种以 PINO 作为夺氢试剂对金刚烷衍生物进行选择性 C(sp3)-H 氰化的新方法。氰基由此从对甲苯磺酰氰转移，使金刚烷衍生物氰化的产率高达 71%。该协议提出了一种新的方法来正交功能化金刚烷，否则很难制备。机理研究支持激进途径的假设。
• Lewis Acid-Catalyzed Preparation of Bridge-head Adamantanoid Nitriles from their Corresponding Halides and Trimethylsilyl Cyanide
  作者：George A. Olah、Omar Farooq、G. K. Surya Prakash

  DOI：10.1055/s-1985-31453

  日期：——

  Bridge-head adamantyl and diamantyl nitriles 2 have been prepared in good yields by refluxing the corresponding halides 1 with trimethylsilyl cyanide and tin(IV) chloride in dichloromethane.

  桥头氨基和二氨基腈2是通过将相应卤化物1与三甲基硅氰和四氯化锡在二氯甲烷中回流反应而良好制得的。
• 1-(Adamantyl) amidines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission
  申请人：VERNALIS RESEARCH LIMITED

  公开号：US20030130354A1

  公开（公告）日：2003-07-10

  Use of a compound of the formula (1), wherein X is an alkylene chain comprising 0, 1, 2, 3 or 4 carbon atoms; R 1 , R 2 and R 3 are independently selected from hydrogen, alkyl and aryl; R 4 , R 5 and R 6 are independently selected from hydrogen, alkyl, aryl, halogen and alkoxy; and prodrugs thereof and pharmaceutically acceptable salts thereof; in the manufacture of a medicament for use in the treatment of a condition generally associated with abnormalities in glutamatergic transmission.

  使用公式(1)中的化合物，其中X是一个碳原子数为0、1、2、3或4的烷基链；R1、R2和R3分别选择自氢、烷基和芳基；R4、R5和R6分别选择自氢、烷基、芳基、卤素和烷氧基；以及它们的前药和药物可接受的盐；用于制造治疗通常与谷氨酸能传递异常有关的疾病的药物。
• RADIATION-SENSITIVE RESIN COMPOSITION
  申请人：JSR Corporation

  公开号：EP1602975A1

  公开（公告）日：2005-12-07

  A radiation-sensitive resin composition comprising an acid-labile group-containing resin obtained by living radical polymerization having a specific structure which is insoluble or scarcely soluble in alkali, but becomes alkali soluble by the action of an acid, and a photoacid generator, wherein the ratio of weight average molecular weight to number average molecular weight (weight average molecular weight/number average molecular weight) of the acid-labile group-containing-resin is smaller than 1.5.

  一种辐射敏感树脂组合物，包括一种通过活自由基聚合获得的具有特定结构的含酸基团树脂，该树脂不溶于碱或几乎不溶于碱，但在酸的作用下可溶于碱，还包括一种光酸发生器，其中含酸基团树脂的重量平均分子量与数量平均分子量之比（重量平均分子量/数量平均分子量）小于 1.5。
• FLUORINE-CONTAINING POLYMER, PURIFICATION METHOD, AND RADIATION-SENSITIVE RESIN COMPOSITION
  申请人：JSR Corporation

  公开号：EP2003148A2

  公开（公告）日：2008-12-17

  An object of the present invention is to provide a novel fluorine-containing polymer, a radiation-sensitive resin composition for liquid immersion lithography which contains the fluorine-containing polymer, which leads to a pattern having an excellent shape and excellent depth of focus, wherein the amount of an eluted component in a liquid for liquid immersion lithography such as water that comes in contact with the resist during exposure in liquid immersion lithography is little, and which provides a larger receding contact angle between the resist film and the liquid for liquid immersion lithography such as water, and a method for purifying the fluorine-containing polymer. The present resin composition comprises a novel fluorine-containing polymer (A) containing repeating units represented by the general formulae (1) and (2) and having Mw of 1,000-50,000, a resin (B) having an acid-unstable group, a radiation-sensitive acid generator (C), a nitrogen-containing compound (D) and a solvent (E).

  本发明的目的是提供一种新型含氟聚合物、一种用于液浸光刻的辐射敏感树脂组合物，该组合物含有该含氟聚合物，可使图案具有极佳的形状和极佳的焦深、其中，在液浸光刻过程中，液浸光刻用液体（如水）中与光刻胶接触的被洗脱成分的量很少，而且光刻胶膜与液浸光刻用液体（如水）之间的后退接触角较大；以及一种纯化含氟聚合物的方法。本树脂组合物包括含有通式（1）和（2）表示的重复单元且 Mw 为 1,000-50,000 的新型含氟聚合物（A）、具有酸不稳定基团的树脂（B）、辐射敏感酸发生器（C）、含氮化合物（D）和溶剂（E）。