3,7-diaminophenothiazine bis(hydrogen chloride)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 3,7-diaminophenothiazine bis(hydrogen chloride)
• 英文别名: 10H-phenothiazin-10-ium-3,7-diamine;chloride
• 化学式: C₁₂H₁₁N₃S*2ClH
• 分子量: 302.227
• InChiKey: NXOKTIFQCZCONY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.48
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.4
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(3,7-diaminophenothiazin-10-yl)-ethanone 在 盐酸 作用下， 以 水 为溶剂， 反应 0.5h， 生成 3,7-diaminophenothiazine bis(hydrogen chloride)
  参考文献：
  名称：

  Therapeutic use of diaminophenothiazines

  摘要：

  本发明一般涉及用于治疗或预防疾病的方法和材料，例如认知障碍，使用二氨基苯噻嗪。具体而言，它涉及具有优化药代动力学性质的治疗方法，以及旨在改善二氨基苯噻嗪相对认知或中枢神经系统益处的剂型，例如与造血影响相比。

  公开号：

  US09149481B2

文献信息

• Photoelectrochemistry in colloidal systems. Part 2.—A photogalvanic cell based on TiO2 semiconductor colloid
  作者：Prashant V. Kamat

  DOI：10.1039/f19858100509

  日期：——

  the standard reduction potential of the dye. The feasibility of employing a colloidal semiconductor system in the operation of a photogalvanic cell is demonstrated. A photogalvanic power conversion efficiency of 0.002% was achieved with thionine and colloidal TiO2 upon bandgap excitation. The use of TiO2 colloid as a carrier for the deposition of a photoactive or an electroactive species on the electrode

  噻嗪和恶嗪染料已通过带隙激发在胶态TiO 2悬浮液中进行了光电化学还原。染料的单电子还原导致半还原的自由基离子的产生，量子产率高达0.1，进一步歧化产生了稳定的无色染料。发现界面电子转移过程的效率取决于染料的标准还原电位。证明了在光原电池的操作中采用胶体半导体系统的可行性。在带隙激发下，用硫氨酸和胶体TiO 2实现了0.002％的光电电流转换效率。TiO 2的用途 还讨论了将胶体用作在电极表面上沉积光活性或电活性物质的载体。
• Thionine sensitized areobic photooxidation of thiourea in acidic medium
  作者：Rafia Azmat、Nida Saleem

  DOI：10.1007/s11458-011-0235-8

  日期：2011.6

  An investigation of the thionine sensitized aerobic photooxidation of thiourea was observed spectrophotometrically at a wavelength of 598 nm. Articles reported two types of reactions which generally occur in the presence of oxygen: 1) Singlet oxygen, produced by dye sensitization due to the hydrolysis that reacts with thiourea to form oxidative products like urea and other sulfur-containing fragments and 2) bleaching of dye, which leads to the reduction. The rate of reaction in all studied parameters followed first order kinetics with respect to maximum absorption of the dye in the visible band region. Reaction kinetics was significantly dependent upon the medium and the reaction accelerated more rapidly at low pH. A direct relation was exhibited between the thiourea concentration and dye sensitizer, which was not pragmatic with the concentration of dye. The reaction was effected by the temperature, and the values of energy parameters suggested that the energy of activation was low while the entropy of activation increases with the rise in temperature, which indicated a highly solvated state of intermediate complex. Lower value of ΔH* and ΔG* at elevated temperature showed that free energy is the driving force for the completion of reaction. A mechanism based on the above findings has been suggested.

  通过分光光度法，在波长为598 nm处观察了硫脲对噻吩敏化的有氧光氧化的研究。文章报道了两种通常在氧气存在下发生的反应：1）单线态氧，由染料敏化产生，由于水解与硫脲反应形成氧化产物，如尿素和其他含硫碎片；2）染料的漂白，导致还原。在所有研究参数中，反应速率遵循一阶动力学，与染料在可见光波段的最大吸收有关。反应动力学明显取决于介质，在低pH值下反应加速更快。硫脲浓度与染料敏化剂之间存在直接关系，这与染料浓度无关。反应受温度影响，能量参数值表明活化能较低，而活化熵随温度升高而增加，这表明中间体复合物处于高度溶解状态。高温下ΔH*和ΔG*的较低值表明自由能是完成反应的驱动力。基于上述发现，提出了一个机制。
• WO2007/110627
  申请人：——

  公开号：——

  公开（公告）日：——
• Therapeutic use of diaminophenothiazines
  申请人：Wischik Claude Michel

  公开号：US09149481B2

  公开（公告）日：2015-10-06

  The present invention relates generally to methods and materials for use in the treatment or prophylaxis of diseases, for example cognitive disorders, using diaminophenothiazines. In particular it relates to treatments having optimised pharmacokinetic properties, and dosage forms are intended to improve the relative cognitive or CNS benefits of the diaminophenothiazines, for instance compared to haematological effects.

  本发明一般涉及用于治疗或预防疾病的方法和材料，例如认知障碍，使用二氨基苯噻嗪。具体而言，它涉及具有优化药代动力学性质的治疗方法，以及旨在改善二氨基苯噻嗪相对认知或中枢神经系统益处的剂型，例如与造血影响相比。