1-amino-4-(2-pyridyl)piperazine | 40966-34-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-amino-4-(2-pyridyl)piperazine
• 英文别名: 4-[2]pyridyl-piperazinoamine；4-[2]Pyridyl-piperazinoamin；4-(Pyridin-2-yl)piperazin-1-amine；4-pyridin-2-ylpiperazin-1-amine
• CAS: 40966-34-5
• 化学式: C₉H₁₄N₄
• mdl: MFCD02163990
• 分子量: 178.237
• InChiKey: IHQKKOYVYPDVJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.444
• 拓扑面积：
  45.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-amino-4-(2-pyridyl)piperazine 在 镍 氢气 作用下， 以 乙醚 、 乙醇 、 乙二醇甲醚 、 N,N-二甲基甲酰胺 为溶剂， 20.0~100.0 ℃ 、207.73 kPa 条件下， 反应 4.0h， 生成
  参考文献：
  名称：

  6-Aminoquinolones as New Potential Anti-HIV Agents

  摘要：

  A series of 6-aminoquinolone compounds were evaluated for their in vitro activity against human immunodeficiency virus type 1 (HIV-1). Compound 12a, bearing a methyl substituent at the N-1 position and a 4-(2-pyridyl)-1-piperazine moiety at the C-7 position, was the most active in inhibiting HIV-1 replication on de novo infected C8166 human lymphoblastoid cell lines. The 12a EC50 value was 0.1 mu M, a 7-20-fold lower concentration relative to that for compounds 8a and 7a containing a cyclopropyl and tert-butyl substituent at the N-1 position, respectively. When the C-6 amino group was replaced with a fluorine atom, a decreased antiviral effect was observed. The observed effects are selective, since potency is substantially reduced when testing the compounds against the herpes simplex virus type 1 (HSV-1). Active quinolone derivatives very efficiently interact with TAR RNA, which suggests a nucleic acid-targeted mechanism of action.

  DOI：

  10.1021/jm9903390
• 作为产物：
  描述：

  1-nitroso-4-(pyridin-2-yl)piperazine 在 溶剂黄146 、 锌 作用下， 生成 1-amino-4-(2-pyridyl)piperazine
  参考文献：
  名称：

  1-substituted-4-aminopiperazines and method of preparing the same

  摘要：

  公开号：

  US02663706A1

文献信息

• [EN] NEW 6-AMINO-QUINOLINONE COMPOUNDS AND DERIVATIVES AS BCL6 INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS 6-AMINO-QUINOLINONE ET DÉRIVÉS EN TANT QU'INHIBITEURS DE BCL6
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2018108704A1

  公开（公告）日：2018-06-21

  The present invention encompasses compounds of formula (I), wherein the groups R1 to R5, X, Y and W have the meanings given in the claims and specification, their use as inhibitors of BCL6, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.

  本发明涵盖了式(I)的化合物，其中基团R1至R5、X、Y和W具有权利要求和说明中给定的含义，它们作为BCL6的抑制剂的用途，含有这种化合物的药物组合物以及它们作为药物的用途，特别是作为治疗和/或预防肿瘤疾病的药剂。
• C20 Through C26 amino steroids
  申请人：THE UPJOHN COMPANY

  公开号：EP0263213B1

  公开（公告）日：1995-09-06
• Amino piperazines and methods of preparing the same
  申请人：AMERICAN CYANAMID CO

  公开号：US02663707A1

  公开（公告）日：1953-12-22
• DE943943
  申请人：——

  公开号：——

  公开（公告）日：——
• DE942029
  申请人：——

  公开号：——

  公开（公告）日：——