3-{[(9H-芴-9-基甲氧基)羰基]氨基}-2-苯丙酸 | 683217-60-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: 3-{[(9H-芴-9-基甲氧基)羰基]氨基}-2-苯丙酸
• 中文别名: Fmoc-（R，S）-3-氨基-2-苯基丙酸
• 英文名称: Fmoc-protected 3-amino-2-phenylpropionic acid
• 英文别名: N-Fmoc-DL-β-phenyl-β-alanine；3-(9H-fluoren-9-ylmethoxycarbonylamino)-2-phenylpropanoic acid
• CAS: 683217-60-9
• 化学式: C₂₄H₂₁NO₄
• 分子量: 387.435
• InChiKey: ZPTZPWOHBIHMIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-{[(9H-芴-9-基甲氧基)羰基]氨基}-2-苯丙酸 生成 N-(N-4-amidinobenzoyl-β-phenyl-β-alanyl)-4-piperidineacetic acid
  参考文献：
  名称：

  Fibrinogen receptor antagonist and pharmaceutical compositions

  摘要：

  以下一般式（I）的化合物及其药用可接受的盐。

  公开号：

  US05866592A1

文献信息

• CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS
  申请人：Bapat Abhijit S.

  公开号：US20140364595A1

  公开（公告）日：2014-12-11

  The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA) m -X-(L) n ; (ii) [(AFA) m′ -X] p -L; (iii) AFA-[X-(L) n′ ] q ; or (iv) (AFA) m″ -X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m′ is 1 to 10; p is 1 to 10; n′ is 1 to 10; and q is 1 to 10, provided that q′ and n are not both 1; and m″ is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.

  该发明提供了由至少一种抗真菌剂或抗菌剂与至少一种连接剂和/或载体偶联形成的基于共轭的抗真菌或抗菌前药。这些前药的公式为：(i) (AFA) m -X-(L) n ; (ii) [(AFA) m′ -X] p -L; (iii) AFA-[X-(L) n′ ] q ; 或 (iv) (AFA) m″ -X，其中：AFA是抗真菌剂或抗菌剂；L是载体；X是连接剂；m范围从1到10；n范围从2到10；m′为1到10；p为1到10；n′为1到10；q为1到10，前提是q'和n不同时为1；m″为1到10。该发明还提供了包含基于共轭的前药的纳米粒子。此外，该发明还提供了以纳米粒子形式的非共轭抗真菌和抗菌剂。
• GRAMICIDIN A MUTANTS THAT FUNCTION AS ANTIBIOTICS WITH IMPROVED SOLUBILITY AND REDUCED TOXICITY
  申请人：Trustees of boston College

  公开号：US20150239936A1

  公开（公告）日：2015-08-27

  Described herein are antimicrobial peptides for use in pharmaceutical antibiotic compositions and methods of use thereof. These antimicrobial peptides are Gramicidin A (gA) peptide analogs that, in addition to having potent anti-microbial activity, have greatly increased solubility and significantly reduced toxicity in comparison to the wild-type Gramicidin A peptide.

  本文描述了用于制药抗生素组合物中的抗菌肽及其使用方法。这些抗菌肽是革兰氏阴性杆菌A（gA）肽类似物，除了具有强大的抗微生物活性外，与野生型革兰氏阴性杆菌A肽相比，它们具有极大的溶解性和显著降低的毒性。
• Lin28/let-7 crystal structures, purification protocols, and molecular probes suitable for screening assays and therapeutics
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US10000756B2

  公开（公告）日：2018-06-19

  The invention provides compositions and methods for regulating microRNA (miRNA) biogenesis. The invention also relates to compositions and methods for treating or preventing cancer in a subject in need thereof.

  本发明提供了调节微RNA（miRNA）生物发生的组合物和方法。本发明还涉及用于治疗或预防癌症的组合物和方法。
• New polyamine-sensitive inhibitors of the NMDA receptor: Syntheses and pharmacological evaluation
  作者：Thomas Pöhler、Oliver Schadt、Daniela Niepel、Patrick Rebernik、Michael L. Berger、Christian R. Noe

  DOI：10.1016/j.ejmech.2006.09.017

  日期：2007.2

  Derivatives of 5-(4-an-nobutyl)-2-thiophene-octylamine, a potent polyamine-sensitive inhibitor of the NMDA receptor, were synthesized and evaluated as inhibitors of [H-3]MK-801 binding to rat brain membranes. Alkylations of the terminal amino groups reduced inhibitory potency; only incorporation of the amino group of the short 4-aminobutyl arm into a piperidine ring was tolerated. Substitution of the thiophene nucleus with methyl or ethyl, and its replacement by a benzene nucleus, was of minor influence. The corresponding diguanidines exhibited high potency independent of chain length, whereas their sensitivity to spermine was sharply dependent on chain length. Insertion of an amide bond into the long octylamine arm increased sensitivity to spermine and to Tris buffer. Our results indicate that spermine sensitivity of [H-3]MK-801 binding inhibition is responsive to subtle changes in inhibitor structure and represents a promising target for pharmaceutical research. (c) 2006 Elsevier Masson SAS. All rights reserved.
• FIBRINOGEN RECEPTOR ANTAGONISTS HAVING SUBSTITUTED (b)-AMINO ACID RESIDUES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
  申请人：Nippon Steel Corporation

  公开号：EP0800516B1

  公开（公告）日：2001-09-19