2-phenyl-3-(m-tolyl)quinazolin-4(3H)-one | 37856-15-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-phenyl-3-(m-tolyl)quinazolin-4(3H)-one
• 英文别名: 2-phenyl-3-m-tolyl-3H-quinazolin-4-one；2-phenyl-3-m-tolyl-3H-quinazolin-4-one；2-Phenyl-3-m-tolyl-3H-chinazolin-4-on；3-(3-Methylphenyl)-2-phenylquinazolin-4-one
• CAS: 37856-15-8
• 化学式: C₂₁H₁₆N₂O
• 分子量: 312.371
• InChiKey: MZKDLYVAAOZTCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(3-methylphenyl)benzimidoyl chloride 在 sodium dithionite 、 乙醇 作用下， 生成 2-phenyl-3-(m-tolyl)quinazolin-4(3H)-one
  参考文献：
  名称：

  Familial Aggregation of 7-Year Changes in Musculoskeletal Fitness

  摘要：

  The purpose of this study was to determine the degree of familial resemblance in baseline and 7-year changes in musculoskeletal fitness. Data front the 1981 Canada Fitness Survey and the Campbell's Survey 7-year follow-up were used. The sample consisted of 1264 people (635 males and 629 females) between the ages of 7 and 69 years for whom measurements of musculoskeletal fitness were available at baseline. A subsample of 834 people had measurements at both baseline and 7-year follow-up. Sit-and-reach trunk flexibility, number of push-ups without time limit, number of sit-ups in 60 seconds, and hand-grip strength were used as indicators of musculoskeletal fitness. The data were adjusted for the effects of age and body mass index (and baseline level of the variable for changes) by using regression procedures, and they were standardized to zero mean and unit variance within each of the four sex-by-generation groups (fathers, mothers, sons, and daughters), Familial correlation models were fitted to the data by using the computer software SEGPATH. The results indicate significant familial resemblance for all indicators of musculoskeletal fitness for baseline measures and 7-year changes. The heritabilities, or the percentages of the total variance attributable to heredity, were 64% for trunk flexibility, 37% for push-ups, 59% for sit-ups, and 48% for grip strength. Similarly, heritabilities for the change scores were 48% for trunk flexibility, 52% for push-ups, 41% for sit-ups, and 32% for grip strength. The results suggest that familial, and perhaps genetic, factors are important in explaining the variance in musculoskeletal fitness not only cross-sectionally but also for changes over time.

  DOI：

  10.1093/gerona/56.12.b497

文献信息

• Palladium-Catalyzed Oxidative Three-Component Coupling of Anthranilamides with Isocyanides and Arylboronic Acids: Access to 2,3-Disubstituted Quinazolinones
  作者：Chun Qian、Kui Liu、Shou-Wei Tao、Fang-Ling Zhang、Yong-Ming Zhu、Shi-Lin Yang

  DOI：10.1021/acs.joc.8b01218

  日期：2018.8.17

  A novel palladium-catalyzed oxidative three-component coupling of easily accessible N-substituted anthranilamides with isocyanides and arylboronic acids is achieved. This protocol offers an alternative approach toward 2,3-disubstituted quinazolinones with a wide substrate scope and good functional group tolerance.

  实现了易于获得的N-取代邻氨基苯甲酰胺与异氰化物和芳基硼​​酸的新型钯催化的氧化三组分偶联。该协议为具有较宽的底物范围和良好的官能团耐受性的2，3-二取代的喹唑啉酮提供了另一种方法。
• Iron-Catalyzed One-Pot 2,3-Diarylquinazolinone Formation from 2-Nitrobenzamides and Alcohols
  作者：Huamin Wang、Xiangxiang Cao、Fuhong Xiao、Saiwen Liu、Guo-Jun Deng

  DOI：10.1021/ol402350x

  日期：2013.9.20

  A novel approach for the synthesis of 2,3-diarylquinazolinones using iron as catalyst is described. Various 2-nitro-N-arylbenzamides reacted with benzylic alcohols to selectively give the corresponding products in the absence of external oxidant or reductant.
• The Characterization of Bronchoalveolar Lavage Fluid in Very Elderly Patients With Cerebrovascular Disease
  作者：M. Kikawada、T. Oyama、K. Ogawa、H. Arai、T. Iwamoto、M. Takasaki

  DOI：10.1093/gerona/56.12.m771

  日期：2001.12.1

  Background. Elderly patients with cerebrovascular disease have a high frequency of pneumonia due to impaired immune function and the occurrence of micro-aspiration.Methods. We performed bronchoalveolar lavage in I I very elderly subjects with cerebrovascular disease and 9 healthy volunteers to investigate whether there were changes of local immunity in the lungs of the elderly subjects. The total cell count. the cell characteristics, and the lymphocyte subsets in bronchoalveolar lavage fluid were compared between the two groups.Results. A significant increase in the total cell count as well as in the number of neutrophils and CD8(-) T cells was observed in the elderly group. In addition, the mean CD4/CD8 lymphocyte ratio was lower in the elderly patients than in the healthy volunteers.Conclusions. These observations suggest that silent micro-aspiration occurs in many elderly individuals with cerebrovascular disease and that pulmonary defenses decrease with age.
• Etude sur les dérivés benzoylés de l'indigo V
  作者：Henri de Diesbach、Otto Jacobi、Carlo Taddei

  DOI：10.1002/hlca.19400230163

  日期：——
• Familial Aggregation of 7-Year Changes in Musculoskeletal Fitness
  作者：P. T. Katzmarzyk、N. Gledhill、L. Perusse、C. Bouchard

  DOI：10.1093/gerona/56.12.b497

  日期：2001.12.1

  The purpose of this study was to determine the degree of familial resemblance in baseline and 7-year changes in musculoskeletal fitness. Data front the 1981 Canada Fitness Survey and the Campbell's Survey 7-year follow-up were used. The sample consisted of 1264 people (635 males and 629 females) between the ages of 7 and 69 years for whom measurements of musculoskeletal fitness were available at baseline. A subsample of 834 people had measurements at both baseline and 7-year follow-up. Sit-and-reach trunk flexibility, number of push-ups without time limit, number of sit-ups in 60 seconds, and hand-grip strength were used as indicators of musculoskeletal fitness. The data were adjusted for the effects of age and body mass index (and baseline level of the variable for changes) by using regression procedures, and they were standardized to zero mean and unit variance within each of the four sex-by-generation groups (fathers, mothers, sons, and daughters), Familial correlation models were fitted to the data by using the computer software SEGPATH. The results indicate significant familial resemblance for all indicators of musculoskeletal fitness for baseline measures and 7-year changes. The heritabilities, or the percentages of the total variance attributable to heredity, were 64% for trunk flexibility, 37% for push-ups, 59% for sit-ups, and 48% for grip strength. Similarly, heritabilities for the change scores were 48% for trunk flexibility, 52% for push-ups, 41% for sit-ups, and 32% for grip strength. The results suggest that familial, and perhaps genetic, factors are important in explaining the variance in musculoskeletal fitness not only cross-sectionally but also for changes over time.