4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-{[(1R)-1-phenylethyl]amino}-10H-phenothiazin-10-yl)butan-2-ol | 1442371-65-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-{[(1R)-1-phenylethyl]amino}-10H-phenothiazin-10-yl)butan-2-ol
• 英文别名: 4-[2-(4-methoxyphenyl)tetrazol-5-yl]-1-[2-[[(1R)-1-phenylethyl]amino]phenothiazin-10-yl]butan-2-ol
• CAS: 1442371-65-4
• 化学式: C₃₂H₃₂N₆O₂S
• 分子量: 564.711
• InChiKey: GLEJPYOKMOEUCV-FPSALIRRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  41
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  10-{(1E,3Z)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]buta-1,3-dien-1-yl}-N-[(1R)-1-phenylethyl]-10H-phenothiazin-2-amine 在 dimethyl sulfide borane 、 双氧水 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 48.0h， 以46%的产率得到4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-{[(1R)-1-phenylethyl]amino}-10H-phenothiazin-10-yl)butan-2-ol
  参考文献：
  名称：

  Synthesis and pharmacological investigation of new N-hydroxyalkyl-2-aminophenothiazines exhibiting marked MDR inhibitory effect

  摘要：

  Novel N-hydroxyalkyl-2-aminophenothiazines implying a tetrazole moiety at the alkyl chain have been synthesized by hydroboration oxidation of dienes followed by Buchwald Hartwig cross-coupling reaction. Also, some sulfoxide and sulfone derivatives have been prepared by selective oxidations. MDR inhibition studies on rat hepatocyte cell culture revealed that some derivatives exhibit marked biological efficacy exceeding that of the standard verapamil (e.g., 3h, 4h, 16). Selected derivatives were subjected to chemical resolution to provide both enantiomers which were shown of similar activity on P-gp interaction measurements. The new compounds exhibited no toxicity. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.04.034

文献信息

• Synthesis and pharmacological investigation of new N-hydroxyalkyl-2-aminophenothiazines exhibiting marked MDR inhibitory effect
  作者：Daniella Takács、Orsolya Egyed、László Drahos、Pál Szabó、Katalin Jemnitz、Mónika Szabó、Zsuzsa Veres、Júlia Visy、József Molnár、Zsuzsanna Riedl、György Hajós

  DOI：10.1016/j.bmc.2013.04.034

  日期：2013.7

  Novel N-hydroxyalkyl-2-aminophenothiazines implying a tetrazole moiety at the alkyl chain have been synthesized by hydroboration oxidation of dienes followed by Buchwald Hartwig cross-coupling reaction. Also, some sulfoxide and sulfone derivatives have been prepared by selective oxidations. MDR inhibition studies on rat hepatocyte cell culture revealed that some derivatives exhibit marked biological efficacy exceeding that of the standard verapamil (e.g., 3h, 4h, 16). Selected derivatives were subjected to chemical resolution to provide both enantiomers which were shown of similar activity on P-gp interaction measurements. The new compounds exhibited no toxicity. (C) 2013 Elsevier Ltd. All rights reserved.