2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine | 737754-25-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine
• CAS: 737754-25-5
• 化学式: C₈H₈F₃N₃
• 分子量: 203.167
• InChiKey: OOHUOYPEBUGEJR-UHFFFAOYSA-N

物化性质

• 沸点：
  214.7±40.0 °C(Predicted)
• 密度：
  1.334±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tert-butyl [(1S,2R)-5-oxo-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate 、 2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine 在 甲醇 、 decaborane 作用下， 反应 2.0h， 生成
  参考文献：
  名称：

  [EN] AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
  [FR] AMINOCYCLOHEXANES EN TANT QU'INHIBITEURS DE DIPEPTIDYL PEPTIDASE-IV POUR LE TRAITEMENT OU LA PRÉVENTION DE DIABÈTES

  摘要：

  本发明涉及一种新型的取代氨基环己烷，它们是二肽基肽酶-IV酶（'DPP-IV抑制剂'）的抑制剂，并且在治疗或预防涉及二肽基肽酶-IV酶的疾病中具有用处，如糖尿病，特别是2型糖尿病。该发明还涉及包含这些化合物的药物组合物以及在预防或治疗涉及二肽基肽酶-IV酶的这类疾病中使用这些化合物和组合物。

  公开号：

  WO2006009886A1

文献信息

• Quinoline derivatives as neurokinin receptor antagonists
  申请人：Carling William Robert

  公开号：US20090054440A1

  公开（公告）日：2009-02-26

  The present invention relates to substituted quinoline hydrazides of Formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, Y and Z are defined herein, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-2 and/or neurokinin-3 (NK-3) receptors. These compounds can thus be used in methods of treatment to suppress and treat such disorders.

  本发明涉及式(I)所示的取代喹啉酰肼：其中R1、R2、R3、R4、R5、X、Y和Z在此定义，包含它们的药物组合物及其在治疗由神经激肽-2和/或神经激肽-3 (NK-3)受体介导的疾病中的用途。因此，这些化合物可用于治疗方法，以抑制和治疗这些疾病。
• [EN] SPIROALKENE CARBOXAMIDE DERIVATIVES AND THEIR USE AS CHEMOKINE RECEPTOR MODULATORS<br/>[FR] DÉRIVÉS DE SPIROALCÈNECARBOXAMIDE ET LEUR UTILISATION COMME MODULATEURS DE RÉCEPTEURS DE CHEMOKINES
  申请人：ARES TRADING SA

  公开号：WO2012130915A1

  公开（公告）日：2012-10-04

  The present invention is directed to compounds of Formula (I) below, which are antagonists to the chemoattractant cytokine receptor 2 (CCR2), and/or 5 (CCR5), pharmaceutical compositions, and methods for use thereof.

  本发明涉及以下式（I）的化合物，这些化合物是趋化因子细胞因子受体2（CCR2）和/或5（CCR5）的拮抗剂，以及其药物组合物和使用方法。
• [EN] A METHOD OF PREPARING 3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOIC ACID DERIVATIVES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS D'ACIDE 3-AMINO-4-(2,4,5-TRIFLUOROPHÉNYL)BUTANOÏQUE
  申请人：ZENTIVA KS

  公开号：WO2014086325A1

  公开（公告）日：2014-06-12

  The invention provides a new method of preparing 3-arnino-4-(2,4,5-trifluorophenyl)butanoic acid derivatives of general formula (1), which are mainly useful as advanced intermediates of some dipeptidyl peptidase-4 (DPP-4) inhibitors. Pg is a commonly used protecting group, especially t-butyloxycarbonyl (Boc), benzyloxycarbonyl (Cbz), acetyl or trifluoroacetyl, and R is NR1R2, wherein R1 and R2 is the same or different substituent, which may be hydrogen, a substituted or unsubstituted C1-6 alkyl, or R1 together with R2 form a substituted or unsubstituted 4-, 5-, or 6-membered heterocyclic containing at least one nitrogen atom, especially a derivative of piperazine. The reaction is carried out using condensation reagent of general formula (3), wherein X is a halide anion, and the reaction is carried out in the environment of a polar organic solvent.

  本发明提供了一种制备通式（1）中的3-氨基-4-(2,4,5-三氟苯基)丁酸衍生物的新方法，它们主要用作一些二肽基肽酶-4（DPP-4）抑制剂的先进中间体。Pg是一种常用的保护基，尤其是叔丁氧羰基（Boc）、苄氧羰基（Cbz）、乙酰基或三氟乙酰基，而R是NR1R2，其中R1和R2是相同或不同的取代基，可以是氢、取代或未取代的C1-6烷基，或R1与R2一起形成取代或未取代的4、5或6元杂环，其中至少含有一个氮原子，尤其是哌嗪的衍生物。反应是使用通式（3）的缩合试剂进行的，其中X是卤素阴离子，并在极性有机溶剂环境中进行反应。
• Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
  申请人：Mathvink J. Robert

  公开号：US20060040963A1

  公开（公告）日：2006-02-23

  The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及一种双肽酶IV酶（“DP-IV抑制剂”）的抑制剂化合物，可用于治疗或预防双肽酶IV酶参与的疾病，例如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗双肽酶IV酶参与的这些疾病中使用这些化合物和组合物的用途。
• Aminocyclohexanes as Dipeptidyl Peptidase-Iv Inhibitors for the Treatment or Prevention of Diabetes
  申请人：Biftu Tesfaye

  公开号：US20070254865A1

  公开（公告）日：2007-11-01

  The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及新型的取代氨基环己烷，其为二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂，并且对于二肽基肽酶-IV酶参与的疾病，例如糖尿病和特别是2型糖尿病的治疗或预防有用。该发明还涉及包含这些化合物的制药组合物以及在预防或治疗二肽基肽酶-IV酶参与的这些疾病中使用这些化合物和组合物。