4-ethoxy-2,3,6-trimethyl-phenol | 53651-60-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-ethoxy-2,3,6-trimethyl-phenol
• 英文别名: Aethyl-(4-hydroxy-2.3.5-trimethyl-phenyl)-aether；3-Hydroxy-6-aethoxy-1.2.4-trimethyl-benzol；4-Aethoxy-2,3,6-trimethyl-phenol；4-Ethoxy-2,3,6-trimethylphenol
• CAS: 53651-60-8
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: FHOWSYMVVKGZTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-ethoxy-2,3,6-trimethyl-phenol 在 sodium methylate 、 四氯化锡 作用下， 以 苯 为溶剂， 生成 (2S,3R,4S,5R,6R)-2-(4-Ethoxy-2,3,6-trimethyl-phenoxy)-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol
  参考文献：
  名称：

  Inhibitory Effects of (4-Alkoxy-2,3,6-trimethylphenyl)glycopyranosides on Histamine Release Induced by Antigen-Antibody Reaction.

  摘要：

  检测了新合成的4-烷氧基-2,3,6-三甲基苯基D-吡喃糖苷对由抗原-抗体反应引起的组胺释放的抑制作用。在测试的化合物中,4-己氧基-2,3,6-三甲基苯基α-D-甘露糖吡喃糖苷表现出最强的抑制作用。此外,4-己氧基-2,3,6-三甲基苯基α-D-吡喃葡糖苷和α-D-吡喃半乳糖苷显著抑制抗原诱导的组胺释放,且它们的活性强于相应的β-异构体。这些结果表明这些化合物可能具有优秀的抗过敏活性。

  DOI：

  10.1248/cpb.42.1002
• 作为产物：
  描述：

  乙醇 、 三甲基氢醌 在 phosphomolybdic acid 作用下， 反应 6.0h， 以70%的产率得到4-ethoxy-2,3,6-trimethyl-phenol
  参考文献：
  名称：

  对苯二酚单烷基醚的合成及其抗脂质过氧化活性。

  摘要：

  合成了一系列氢醌单烷基醚，并评估了其在大鼠肝微粒体中的抗脂质过氧化活性。氧化还原电位低的4-己氧基-2,3,6-三甲基苯酚（9）以及抗坏血酸表现出最强的抗脂质过氧化活性（IC50 = 4.2 x 10（-7）M）。结构活性关系研究表明，对苯二酚单烷基醚对脂质过氧化的抑制作用通过获得最佳疏水性而增加，而由于疏水性不足或过度而降低。

  DOI：

  10.1248/cpb.42.576

文献信息

• John; Rathmann, Chemische Berichte, 1941, vol. 74, p. 890,896
  作者：John、Rathmann

  DOI：——

  日期：——
• DE2300543
  申请人：——

  公开号：——

  公开（公告）日：——
• Influence of variety on the within-plant distribution of cassava green spider mite (Acari: Tetranychidae), and leaf anatomical characteristics and chemical components in relation to varietal resistance
  作者：E. N. Nukenine、A. T. Hassan、A. G. O. Dixon

  DOI：10.1080/096708700415508

  日期：2000.1

  The within-plant distribution of the cassava green spider mite, Mononychellus tanajoa Bondar, and the anatomical characteristics and the chemical components relating to varietal resistance of cassava, were studied using 11 cassava genotypes with varying levels of resistance for two dry seasons and one wet season. The results show that M. tanajoa aggregates on the top leaves of cassava at low levels of resistance as compared with a more even within-plant distribution at higher levels of resistance. Thus, for accurate sampling of mite populations, it might be important to consider young and old leaves, not just the young leaves, in fields containing resistant and susceptible cassava genotypes. Correlations between the anatomical characteristics and mite population density and damage scores were not consistent across months, either within or over seasons. This suggests that leaf anatomical characteristics may not be important in the varietal resistance of cassava to M. tanajoa. During the dry season, mite population density was positively correlated with leaf nitrogen, potassium and phosphorus and negatively correlated with leaf calcium and fat. Only calcium was negatively associated with mite damage at the peak of the dry season (January 1993 and 1994). Breeding cassava genotypes with high levels of leaf calcium and fat, and low levels of leaf nitrogen, potassium and phosphorus, may improve the level of resistance to M. tanajoa.
• [EN] TRAP1 INHIBITOR AND USE THEREOF<br/>[FR] INHIBITEUR DE TRAP1 ET SON UTILISATION<br/>[KO] TRAP1 억제제 및 이의 용도
  申请人：[en]SMARTIN BIO INC.;[ko]주식회사 스마틴바이오

  公开号：WO2022265178A1

  公开（公告）日：2022-12-22

  본 명세서는 TRAP1을 억제하는 화합물 또는 이의 약학적으로 허용가능한 염을 제공한다. 이때, 상기 화합물 또는 이의 약학적으로 허용가능한 염은 TRAP1과 클라이언트 단백질의 결합을 억제할 수 있다. 또한, 본 명세서는 TRAP1을 억제하는 화합물 또는 이의 약학적으로 허용가능한 염을 포함하는 암 또는 안과질환 치료용 약학적 조성물 및 이의 용도를 제공한다.
• Synthesis and Anti Lipid-Peroxidation Activity of Hydroquinone Monoalkyl Ethers.
  作者：Yasunori NIHRO、Haruhiro FURUKAWA、Satoshi SOGAWA、Tzer Chuan WANG、Hideki MIYATAKA、Hitoshi MATSUMOTO、Tokutaro MIKI、Toshio SATOH

  DOI：10.1248/cpb.42.576

  日期：——

  series of hydroquinone monoalkyl ethers was synthesized and evaluated for anti lipid-peroxidation activity in rat liver microsomes. 4-Hexyloxy-2,3,6-trimethylphenol (9), having a low redox potential, as well as ascorbic acid exhibited the strongest anti lipid-peroxidation activity (IC50 = 4.2 x 10(-7) M). Structure-activity relationship studies demonstrated that the inhibitory effect of hydroquinone monoalkyl

  合成了一系列氢醌单烷基醚，并评估了其在大鼠肝微粒体中的抗脂质过氧化活性。氧化还原电位低的4-己氧基-2,3,6-三甲基苯酚（9）以及抗坏血酸表现出最强的抗脂质过氧化活性（IC50 = 4.2 x 10（-7）M）。结构活性关系研究表明，对苯二酚单烷基醚对脂质过氧化的抑制作用通过获得最佳疏水性而增加，而由于疏水性不足或过度而降低。