2-phenyl-3H-chromeno[3,4-c]pyridine-4,5-dione | 29542-24-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-phenyl-3H-chromeno[3,4-c]pyridine-4,5-dione
• 英文别名: 2-Phenyl-4,5-dioxo-6-oxabenzisochinolin；4-hydroxy-2-phenyl-5H-chromeno[3,4-c]pyridin-5-one；2-phenyl-3H-chromeno[3,4-c]pyridine-4,5-dione
• CAS: 29542-24-3
• 化学式: C₁₈H₁₁NO₃
• 分子量: 289.29
• InChiKey: VAXKJLXXSYPJCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.07
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  4-amino-2-phenylbenzopyrano<3,4-c>pyridin-5-one 在 硫酸 、 sodium nitrite 作用下， 以 溶剂黄146 为溶剂， 生成 2-phenyl-3H-chromeno[3,4-c]pyridine-4,5-dione
  参考文献：
  名称：

  Reynolds,G.A. et al., Journal of Heterocyclic Chemistry, 1970, vol. 7, p. 1061 - 1069

  摘要：

  DOI：

文献信息

• The Cyclization of Ethyl Cyanoacetate and Salicylaldehyde or 3-Methoxysalicylaldehyde with Ketones by Means of Ammonium Acetate
  作者：Akio Sakurai、Hiroshi Midorikawa、Yasuo Hashimoto

  DOI：10.1246/bcsj.43.2925

  日期：1970.9

  prepared by the condensation of ethyl cyanoacetate and salicylaldehyde or 3-methoxysalicylaldehyde with aliphatic ketones (acetone, diethyl ketone, methyl pentyl ketone, methyl isopentyl ketone, etc.) or aromatic ketones (acetophenone, o-hydroxyacetophenone, m-nitroacetophenone, propiophenone, etc.) in the presence of ammonium acetate. On the other hand, condensation with cyclic ketones such as cyclopentanone

  通过氰基乙酸乙酯和水杨醛或 3-甲氧基水杨醛与脂肪族酮（丙酮、二乙酮、甲基戊酮、甲基异戊基酮等）或芳香族酮（苯乙酮、邻苯二甲羟基苯乙酮、间硝基苯乙酮、苯丙酮等）在乙酸铵存在下。另一方面，与环酮如环戊酮和环己酮缩合分别得到苯并[f]环戊[c]异喹啉和苯并[k]菲啶。
• CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES
  申请人：Electrophoretics Limited

  公开号：US20160354375A1

  公开（公告）日：2016-12-08

  The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.