stigmastanol | 19044-02-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: stigmastanol
• 英文别名: (24ξ)-24-ethyl-5α-cholest-3β-ol；24ξ-ethyl-5α-cholestan-3β-ol；24-ethyl-5α-cholestan-3β-ol；24ξ-ethylcholestan-3β-ol；24-ethylcholestan-3β-ol；β-sitostanol；(3S,5S,8R,9S,10S,13R,14S,17R)-17-[(2R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 19044-02-1
• 化学式: C₂₉H₅₂O
• 分子量: 416.731
• InChiKey: LGJMUZUPVCAVPU-OCTCCMJISA-N

物化性质

• 沸点：
  471.9±13.0 °C(Predicted)
• 密度：
  0.948±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  stigmastanol 生成 Stigmastanol acetate
  参考文献：
  名称：

  AKIHISA, TOSHIHIRO;TAMURA, TOSHITAKE;MATSUMOTO, TARO;KOKKE, W. C. M. C.;G+, J. CHEM. SOC. PERKIN TRANS. PT 1,(1990) N, C. 2213-2218

  摘要：

  DOI：
• 作为产物：
  描述：

  (23S)-23,28-cyclostigmasta-5,24(28)-dien-3-β-ol 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 30.0h， 以53%的产率得到(23S,24R,28R)-23,24-dihydrocalystan-3β-ol
  参考文献：
  名称：

  Acid-catalyzed and photochemical isomerization of steroidal cyclopropenes

  摘要：

  DOI：

  10.1021/ja00351a047

文献信息

• Saturated and unsaturated sterols of nitrogen-fixing blue-green algae (cyanobacteria)
  作者：Manfred Kohlhase、Peter Pohl

  DOI：10.1016/0031-9422(88)80434-5

  日期：1988.1

  Abstract Five species of filamentous nitrogen-fixing blue-green algae (Cyanobacteria), ( Anabaena cylindrica , Anabaena solitaria , Anabaena viguieri ,

  摘要 丝状固氮蓝绿藻（Cyanobacteria）5种，（圆柱鱼腥藻、孤鱼鱼腥藻、鱼腥藻、
• GC-Based Analysis of Plant Stanyl Fatty Acid Esters in Enriched Foods
  作者：Andreas Barnsteiner、Tim Lubinus、Angelica di Gianvito、Wolfgang Schmid、Karl-Heinz Engel

  DOI：10.1021/jf104930z

  日期：2011.5.25

  according to their stanol moieties and their fatty acid chains. Thermal degradation during GC analysis was compensated by determining response factors; calibrations were performed for ten individual plant stanyl esters. For the analysis of low-fat products (skimmed milk drinking yogurts), the GC separation was combined with a “fast extraction” under acidic conditions. For fat-based foods (margarines), online

  开发了基于毛细管气相色谱（GC）的分析富含食品中完整植物锡酯的方法。参考化合物是通过酶催化的酯交换反应合成的。通过质谱法确认了他们的身份。使用中等极性的三氟丙基甲基聚硅氧烷固定相，可以根据其甾烷醇部分和脂肪酸链分离长链植物锡酸酯。GC分析过程中的热降解可通过确定响应因子来补偿。对十种植物甾烷酸酯进行了校准。为了分析低脂产品（喝脱脂牛奶的酸奶），在酸性条件下将GC分离与“快速萃取”结合使用。对于脂肪类食品（人造黄油），在线连接的LC-GC提供了一种优雅而有效的方法，从而避免了耗时的样品制备步骤。健壮且快速的方法可以得出甾烷醇谱和脂肪酸部分的结论，从而为鉴定这种类型的功能性食品成分提供了基础。
• Micromilling plant sterols and emulsifiers
  申请人：KRAFT FOODS, INC.

  公开号：EP1142494A1

  公开（公告）日：2001-10-10

  Plant sterols have been shown to be cholesterol-reducing agents in human serum. In the present invention, plant sterols, plant stanols, plant sterol esters and other non-toxic sterols are micromilled with emulsifiers in a solvent (water or edible oil) to produce dispersion which can be incorporated into full-fat, reduced-fat, low-fat, fat-free and triglyceride-free food products. Such water-based or edible oil-based dispersions can be used to incorporate relatively high levels of such sterols/stanols in food products without the adverse organoleptic effect normally associated with the use of such plant sterols and plant stanols.

  植物固醇已被证明是人体血清中的胆固醇降低剂。在本发明中，植物固醇、植物甾醇、植物甾醇酯和其他无毒固醇与乳化剂一起在溶剂（水或食用油）中进行微粉碎，以产生分散液，这种分散液可以掺入全脂、减脂、低脂、无脂和无甘油三酯的食品中。这种水基或食用油基分散体可用来在食品中加入相对高含量的此类固醇/甾醇，而不会产生通常与使用此类植物固醇和植物甾醇相关的不良感官影响。
• Compositions and processes for water-dispersible phytosterols and phytostanols
  申请人：KRAFT FOODS HOLDINGS, INC.

  公开号：EP1632137A1

  公开（公告）日：2006-03-08

  Plant and plant sterol esters have been shown to be cholesterol-reducing agents in human serum. In the present invention, plant sterols and plant stanols are incorporated into compositions which are dispersible in water by complexing the hydrophobic lipids with water-soluble carbohydrates. The resulting plant sterol-carbohydrate complexes are in an aqueous or powder form which can be readily incorporated with food products in an amount effective to reduce serum cholesterol levels in a human consuming such food product, without adversely modifying the organoleptic properties of the food product.

  植物和植物甾醇酯已被证明是人体血清中的胆固醇降低剂。在本发明中，通过将疏水性脂质与水溶性碳水化合物复配，将植物固醇和植物甾醇加入到可在水中分散的组合物中。由此产生的植物固醇-碳水化合物复合物呈水溶液或粉末状，可以很容易地与食品结合在一起，其用量可有效降低食用此类食品的人的血清胆固醇水平，而不会对食品的感官特性产生不利影响。
• Plant sterol-emulsifier complexes
  申请人：KRAFT FOODS, INC.

  公开号：US20010006672A1

  公开（公告）日：2001-07-05

  Plant sterols have been shown to be cholesterol-reducing agents in human serum. In the present invention, plant sterols, plant stanols, plant sterol esters and other non-toxic sterols are co-crystallized with emulsifiers to form a plant sterol/emulsifier complex or plant stanol/emulsifier complex which can be incorporated into full-fat, reduced-fat, low-fat, fat-free and triglyceride-free food products. Plant sterols and plant stanols can be co-crystallized with emulsifiers to produce a blend which has a melting temperature significantly lower than the melting temperature of the plant sterol or plant stanol. Such complexes can be used to incorporate relatively high levels of such sterols/stanols in food products without the adverse organoleptic effect normally associated with the use of such plant sterols and plant stanols.

  植物固醇已被证明是人体血清中的胆固醇降低剂。在本发明中，植物固醇、植物甾醇、植物甾醇酯和其他无毒固醇与乳化剂共同结晶，形成植物固醇/乳化剂复合物或植物甾醇/乳化剂复合物，可掺入全脂、减脂、低脂、无脂和无甘油三酯食品中。植物固醇和植物甾醇可与乳化剂共同结晶，以产生一种熔化温度明显低于植物固醇或植物甾醇熔化温度的混合物。这种复合物可用于在食品中加入相对高含量的此类甾醇/甾烷醇，而不会产生通常与使用此类植物甾醇和植物甾烷醇相关的不良感官影响。