N-环戊基-N-甲基乙二胺 | 859340-58-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-环戊基-N-甲基乙二胺
• 英文名称: N-cyclopentyl-N-methyl-ethylenediamine
• 英文别名: N-Cyclopentyl-N-methyl-aethylendiamin；N-(2-aminoethyl)-N-methylcyclopentanamine；N'-cyclopentyl-N'-methylethane-1,2-diamine
• CAS: 859340-58-2
• 化学式: C₈H₁₈N₂
• mdl: MFCD09754454
• 分子量: 142.244
• InChiKey: YUGHUGYCOBWRDH-UHFFFAOYSA-N

物化性质

• 沸点：
  208.9±8.0 °C(Predicted)
• 密度：
  0.92±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6,9-二氯-2-甲氧基吖啶 、 N-环戊基-N-甲基乙二胺 在 苯酚 作用下， 生成 N'-(6-chloro-2-methoxy-acridin-9-yl)-N-cyclopentyl-N-methyl-ethylenediamine
  参考文献：
  名称：

  2-甲氧基-6-氯-9-（N-取代的氨基）-啶; 衍生自环状仲胺的化合物。

  摘要：

  DOI：

  10.1021/ja01214a012
• 作为产物：
  描述：

  N-cyclopentyl-N-methyl-glycine nitrile 在 乙醚 、 氨 、 镍 作用下， 125.0 ℃ 、12.26 MPa 条件下， 生成 N-环戊基-N-甲基乙二胺
  参考文献：
  名称：

  2-甲氧基-6-氯-9-（N-取代的氨基）-啶; 衍生自环状仲胺的化合物。

  摘要：

  DOI：

  10.1021/ja01214a012

文献信息

• Structure–Activity Relationships of 4-Position Diamine Quinoline Methanols as Intermittent Preventative Treatment (IPT) against <i>Plasmodium falciparum</i>
  作者：Erin Milner、Sean Gardner、Jay Moon、Kristina Grauer、Jennifer Auschwitz、Ian Bathurst、Diana Caridha、Lucia Gerena、Montip Gettayacamin、Jacob Johnson、Michael Kozar、Patricia Lee、Susan Leed、Qigui Li、William McCalmont、Victor Melendez、Norma Roncal、Richard Sciotti、Bryan Smith、Jason Sousa、Anchalee Tungtaeng、Peter Wipf、Geoffrey Dow

  DOI：10.1021/jm200647u

  日期：2011.9.22

  A library of diamine quinoline methanols were designed based on the mefloquine scaffold. The systematic variation of the 4-position amino alcohol side chain led to analogues that maintained potency while reducing accumulation in the central nervous system (CNS). Although the mechanism of action remains elusive, these data indicate that the 4-position side chain is critical for activity and that potency (as measured by IC(90)) does not correlate with accumulation in the CNS. A new lead compound, (S)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-2-(2-(cyclopropylamino)ethylamino)ethanol (WR621308), was identified with single dose efficacy and substantially lower permeability across MDCK cell monolayers than mefloquine. This compound could be appropriate for intermittent preventative treatment (IPTx) indications or other malaria treatments currently approved for mefloquine.
• [EN] PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS<br/>[FR] PYRAZOLOPYRIMIDINES ET LEURS UTILISATIONS EN TANT QU'INHIBITEURS DE PDGFR
  申请人：[en]ACTELION PHARMACEUTICALS LTD

  公开号：WO2023007009A1

  公开（公告）日：2023-02-02

  The disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising compounds of formula (I), as well as methods of their use and preparation, are also described.
• 2-Methoxy-6-chloro-9-(N-substituted-amino)-acridines. II. Compounds Derived from Cyclic Secondary Amines¹
  作者：Joseph Corse、J. T. Bryant、H. A. Shonle

  DOI：10.1021/ja01214a012

  日期：1946.10