CP-4 | 189350-94-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: CP-4
• 英文别名: 1,2,5,6,9,10-hexachlorodecane；CP-5；C10-C13 Chloroparaffin
• CAS: 189350-94-5
• 化学式: C₁₀H₁₆Cl₆
• 分子量: 348.955
• InChiKey: SMINNPBPYQGOQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  1,5,9-decatriene 在 氯 作用下， 生成 CP-4
  参考文献：
  名称：

  Quantifying C₁₀−C₁₃ Polychloroalkanes in Environmental Samples by High-Resolution Gas Chromatography/Electron Capture Negative Ion High-Resolution Mass Spectrometry

  摘要：

  提出了一种在选择离子监测 (SIM) 模式下通过高分辨率气相色谱/电子捕获负离子高分辨率质谱定量环境样品中 C10−C13 多氯烷烃 (PCA) 的方法。商业 PCA 和环境样品中含 PCA 提取物的分子组成首先通过监测与存在的式基相对应的特定 m/z 值的 [M − Cl]- 离子并假设积分离子信号与摩尔浓度成正比来确定。按式组中氯原子数加权的浓度。对于定量测量，为每种分析物选择一个特定的 m/z 峰，并积分其 SIM 响应。积分 SIM 响应与注入的 PCA 量在 0.5−500 ng 范围内呈线性相关。然后描述分析方案。高分辨率（~12 000 分辨率）质谱法被证明可以消除低分辨率（~1000）PCA 之间的自干扰以及工业氯丹、毒杀芬、PCB 和其他有机氯农药的潜在干扰。从鱼中提取 PCA 的平均回收率 >80%。信噪比为 4:1 时，分析检测限为约 60 pg 注射的 PCA，而方法检测限为 23 ng/g。作为该技术应用于“现实世界”问题的例证，底特律河 (MI) 河口的生物群和沉积物样本中的 PCA 水平据报道在 0.3−1.2 μg/g 范围内。

  DOI：

  10.1021/ac961244y

文献信息

• Quantifying C₁₀−C₁₃ Polychloroalkanes in Environmental Samples by High-Resolution Gas Chromatography/Electron Capture Negative Ion High-Resolution Mass Spectrometry
  作者：Gregg T. Tomy、Gary A. Stern、Derek C. G. Muir、Aaron T. Fisk、Chris D. Cymbalisty、John B. Westmore

  DOI：10.1021/ac961244y

  日期：1997.7.1

  A method for quantifying C10−C13 polychloroalkanes (PCAs) in environmental samples by high-resolution gas chromatography/electron capture negative ion high-resolution mass spectrometry in the selected ion monitoring (SIM) mode is presented. The molecular compositions of commercial PCAs and of PCA-containing extracts from environmental samples are first determined by monitoring [M − Cl]- ions of specific m/z value corresponding to formula groups present and by assuming that the integrated ion signals are proportional to molar concentration weighted by the number of chlorine atoms in the formula group. For quantitative measurement, one specific m/z peak is selected for each analyte and its SIM response is integrated. The integrated SIM responses have a linear dependence upon amount of PCA injected over the range 0.5−500 ng. An analytical protocol is then described. High-resolution (∼12 000 resolving power) mass spectrometry is shown to be desirable to eliminate self-interferences between PCAs at low resolving power (∼1000) and potential interferences from technical chlordane, toxaphene, PCBs, and other organochlorine pesticides. Extraction recoveries of PCAs from fish averaged >80%. The analytical detection limit is ∼60 pg of injected PCA, at a signal-to-noise ratio of 4:1, while the method detection limit was 23 ng/g. As illustrations of the application of the technique to “real world” problems, PCA levels in biota and sediment samples from the mouth of the Detroit River (MI) are reported to be in the 0.3−1.2 μg/g range.

  提出了一种在选择离子监测 (SIM) 模式下通过高分辨率气相色谱/电子捕获负离子高分辨率质谱定量环境样品中 C10−C13 多氯烷烃 (PCA) 的方法。商业 PCA 和环境样品中含 PCA 提取物的分子组成首先通过监测与存在的式基相对应的特定 m/z 值的 [M − Cl]- 离子并假设积分离子信号与摩尔浓度成正比来确定。按式组中氯原子数加权的浓度。对于定量测量，为每种分析物选择一个特定的 m/z 峰，并积分其 SIM 响应。积分 SIM 响应与注入的 PCA 量在 0.5−500 ng 范围内呈线性相关。然后描述分析方案。高分辨率（~12 000 分辨率）质谱法被证明可以消除低分辨率（~1000）PCA 之间的自干扰以及工业氯丹、毒杀芬、PCB 和其他有机氯农药的潜在干扰。从鱼中提取 PCA 的平均回收率 >80%。信噪比为 4:1 时，分析检测限为约 60 pg 注射的 PCA，而方法检测限为 23 ng/g。作为该技术应用于“现实世界”问题的例证，底特律河 (MI) 河口的生物群和沉积物样本中的 PCA 水平据报道在 0.3−1.2 μg/g 范围内。
• Synthesis of a derivative of GRF and intermediate peptides
  申请人：Sumitomo Pharmaceuticals Company, Limited

  公开号：US04774319A1

  公开（公告）日：1988-09-27

  A process for the manufacture of a polypeptide (I) having the formula: ##STR1## which comprises steps of: (a) coupling, successively and in the order of the sequence of the polypeptide (I), the four protected fragments A, B, C and D or five protected fragments A, B, C, E and F, said fragment A by the formula, Leu-Gin-Asp-Ile-Met-Ser-Arg-NH.sub.2 said fragment B by the formula, Gln-Leu-Ser-Ala-Arg-Lys-Leu said fragment C by the formula, Arg-Lys-Val-Leu-Gly said fragment D by the formula, Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr said fragment E by the formula, Ile-Phe-Thr-Asn-Ser-Tyr and said fragment F by the formula, Tyr-Ala-Asp-Ala being represented, respectively, and (b) eliminating, at the end of sequence, all the protecting groups to provide the polypeptide (I) which is active on the stimulation of the release of the growth hormone and thus is very useful as medicine for treatment of growth hormone deficiency disease and the like.

  一种制造多肽(I)的方法，其化学式为：##STR1## 包括以下步骤：(a) 按照多肽(I)的序列顺序，依次耦合四个保护的片段A、B、C和D或五个保护的片段A、B、C、E和F，其中片段A的化学式为Leu-Gin-Asp-Ile-Met-Ser-Arg-NH.sub.2，片段B的化学式为Gln-Leu-Ser-Ala-Arg-Lys-Leu，片段C的化学式为Arg-Lys-Val-Leu-Gly，片段D的化学式为Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr，片段E的化学式为Ile-Phe-Thr-Asn-Ser-Tyr，片段F的化学式为Tyr-Ala-Asp-Ala，分别表示，以及(b) 在序列结束时消除所有保护基，以提供对促进生长激素释放活性的多肽(I)，因此非常有用作为治疗生长激素缺乏症等疾病的药物。
• Effects of temperature and sample amount on the electron capture negative ion mass spectra of polychloro-n-alkanes
  作者：Gregg T. Tomy、Sheryl A. Tittlemier、Gary A. Stern、Derek C.G. Muir、John B. Westmore

  DOI：10.1016/s0045-6535(98)00130-1

  日期：1998.9

  Ion source temperature, sample amount and the positions of the chlorine atoms attached to the neutral molecule all had profound effects on the appearance of the ECNI mass spectra of a number of synthesized polychloro-n-alkanes (PCAs). Increases in the ion source temperature resulted in a decrease in the abundances of both the [M + Cl](-) and [M - Cl](-) ions, while the abundances of the structurally non-characteristic ions, HCl2- and Cl-2(-)., increased. An increase in the amount of the injected PCA resulted in an increase in the abundance of the [M + Cl](-) ion, most notably for congeners containing chlorine atoms only 1,2-substituted at both ends of the alkane chain. The abundance of the [M - Cl](-) ion increases with decreasing ion source temperature down to 120 degrees C, the lowest temperature easily maintained with our instrument. For analytical purposes we recommend that this source temperature be used. (C) 1998 Elsevier Science Ltd. All rights reserved.