Tri-N,O,O-(trimethylsilyl)-aminomethylphosphonsaeure | 53044-36-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Tri-N,O,O-(trimethylsilyl)-aminomethylphosphonsaeure
• 英文别名: Phosphonic acid, [[(trimethylsilyl)amino]methyl]-, bis(trimethylsilyl) ester；1-bis(trimethylsilyloxy)phosphoryl-N-trimethylsilylmethanamine
• CAS: 53044-36-3
• 化学式: C₁₀H₃₀NO₃PSi₃
• 分子量: 327.583
• InChiKey: LGIHWBCBJHIWMS-UHFFFAOYSA-N

物化性质

• 保留指数：
  1465

计算性质

• 辛醇/水分配系数(LogP)：
  4.26
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Tri-N,O,O-(trimethylsilyl)-aminomethylphosphonsaeure 、 ethoxycarbonyl (2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoate 以 乙酸乙酯 为溶剂， 反应 1.0h， 生成 [(N-benzyloxycarbonyl-L-phenylalanyl)amino]-methylphosphonic acid
  参考文献：
  名称：

  Preparation of N-Acylated Phosphonopeptides with Free Phosphonic Group

  摘要：

  Aminoalkylphosphonic acids on heating with hexamethyldisilazane yield tris(trimethylsilyl) derivatives, which are used as amino components for the synthesis of N-acylated phosphonopeptides with free phosphonic group. These transformations proceed with complete retention of the stereoconfiguration of aminophosphonate moiety.

  DOI：

  10.1080/00397919108021063
• 作为产物：
  描述：

  氨甲基膦酸 、 六甲基二硅氮烷 以91%的产率得到Tri-N,O,O-(trimethylsilyl)-aminomethylphosphonsaeure
  参考文献：
  名称：

  Preparation of N-Acylated Phosphonopeptides with Free Phosphonic Group

  摘要：

  Aminoalkylphosphonic acids on heating with hexamethyldisilazane yield tris(trimethylsilyl) derivatives, which are used as amino components for the synthesis of N-acylated phosphonopeptides with free phosphonic group. These transformations proceed with complete retention of the stereoconfiguration of aminophosphonate moiety.

  DOI：

  10.1080/00397919108021063

文献信息

• Preparation of N-Acylated Phosphonopeptides with Free Phosphonic Group
  作者：Vladimir Solodenko、Tamara Kasheva、Valeri Kukhar

  DOI：10.1080/00397919108021063

  日期：1991.8

  Aminoalkylphosphonic acids on heating with hexamethyldisilazane yield tris(trimethylsilyl) derivatives, which are used as amino components for the synthesis of N-acylated phosphonopeptides with free phosphonic group. These transformations proceed with complete retention of the stereoconfiguration of aminophosphonate moiety.
• Kukhar, Valery; Solodenko, Vladimir; Soloshonok, Vadim, Phosphorus, Sulfur and Silicon and the Related Elements, 1996, vol. 109, # 1-4, p. 529 - 532
  作者：Kukhar, Valery、Solodenko, Vladimir、Soloshonok, Vadim、Kasheva, Tamara

  DOI：——

  日期：——