2,6-二氨基嘌呤硫酸盐 | 7280-83-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 2,6-二氨基嘌呤硫酸盐
• 中文别名: 2,6-硫酸二氨基嘌呤
• 英文名称: 2,6-diaminopurine sulfate
• 英文别名: 1H-Purine-2,6-diamine, sulfate；7H-purine-2,6-diamine;sulfuric acid
• CAS: 7280-83-3
• 化学式: C₅H₆N₆*H₂O₄S
• 分子量: 248.222
• InChiKey: KYYLASPNTMEZTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.14
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  190
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2,6-二氨基嘌呤硫酸盐 在 Dowex 50X₈ (H-form) 作用下， 以 水 为溶剂， 以92%的产率得到2,6-二氨基嘌呤
  参考文献：
  名称：

  Holy, Antonin; Rosenberg, Ivan; Dvorakova, Hana, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 8, p. 2190 - 2210

  摘要：

  DOI：

文献信息

• Unsaturated and carbocyclic nucleoside analogs: synthesis, antitumor and antiviral activity
  作者：Shashikant Phadtare、David Kessel、Thomas H. Corbett、Harold E. Renis、Barbara E. Court、Jiri Zemlicka

  DOI：10.1021/jm00105a064

  日期：1991.1

  activities were investigated. Alkylation of cytosine with (E)-1,4-dichloro-2-butene gave chloro derivative 2f, which was hydrolyzed to alcohol 2h. Cytosine, adenine, 2-amino-6-chloropurine, thymine, and (Z)-1,4-chloro-2-butene gave compounds 4c-f, which, after hydrolysis, afforded alcohols 4a, 4b, 4g, and 4h. Alkenes 4d and 4e were cyclized to heterocycles 12 and 13. Alkylation of 2,6-diaminopurine with

  制备了一系列核苷的不饱和类似物，并研究了它们的细胞毒性，抗肿瘤和抗病毒活性。用（E）-1，4-二氯-2-丁烯烷基化胞嘧啶，得到氯衍生物2f，将其水解成醇2h。胞嘧啶，腺嘌呤，2-氨基-6-氯嘌呤，胸腺嘧啶和（Z）-1,4-氯-2-丁烯得到化合物4c-f，水解后得到醇4a，4b，4g和4h。烯烃4d和4e环化成杂环12和13。2，6-二氨基嘌呤与1，4-二氯-2-丁炔的烷基化产生氯代衍生物6a，后者被水解成醇6b。6b的烯丙基异构化得到化合物5c。氯衍生物2e-g，4c-f，5d和6c-e以及嘧啶氧杂环戊烯9c和9d是IC50 10-100 microM的鼠白血病L1210的缓效抑制剂。最活跃的是类似物4c，4d，4e，和6e（IC50 10-20 microM）。相应的羟基衍生物的活性较小。用化合物4c，4d，6e，9c和9d抑制大分子合成的顺序如下：DNA大于RNA大于或等于蛋白质。四种
• 2-Substituted adenosine-5'-carboxylates in the treatment of anginal pain
  申请人：Abbott Laboratories

  公开号：US03992531A1

  公开（公告）日：1976-11-16

  2-Substituted adenosine-5'-carboxylates represented by the formula ##SPC1## Wherein R is amino, acetamido or hydroxy, R.sub.1 is loweralkyl, haloloweralkyl, hydroxyloweralkyl, lowercycloalkyl, loweralkenyl, loweralkynyl, loweralkyl(C.sub.3 -C.sub.6)cycloalkyl or alkoxyalkyl and R.sub.2 and R.sub.3 each are hydrogen or acyl, or R.sub.2 and R.sub.3 taken together form an isopropylidene or benzylidene moiety; and the pharmaceutically acceptable acid addition salts thereof. The compounds wherein R.sub.2 and R.sub.3 are hydrogen or acyl are useful in treating cardiovascular disorders and are particularly useful as anti-anginal agents. Compounds wherein R.sub.2 and R.sub.3 when taken together form an isopropylidene or benzylidene moiety are intermediates useful in making the final products.

  公式为##SPC1##的2-取代腺苷-5'-羧酸酯，其中R为氨基，乙酰胺基或羟基，R.sub.1为较低的烷基，卤代较低的烷基，羟基较低的烷基，较低的环烷基，较低的烯基，较低的炔基，较低的烷基（C.sub.3-C.sub.6）环烷基或烷氧基烷基，R.sub.2和R.sub.3各自为氢或酰基，或R.sub.2和R.sub.3结合形成异丙基亚甲基或苄亚甲基基团;以及其药学上可接受的酸盐。其中R.sub.2和R.sub.3为氢或酰基的化合物在治疗心血管疾病方面有用，并且特别有用作为抗心绞痛剂。当R.sub.2和R.sub.3结合形成异丙基亚甲基或苄亚甲基基团时，这些化合物是制作最终产品的中间体。
• Joshi, Ramachandra V.; Xu, Ze-Qi; Ksebati, Mahamad B., Journal of the Chemical Society. Perkin transactions I, 1994, # 8, p. 1089 - 1098
  作者：Joshi, Ramachandra V.、Xu, Ze-Qi、Ksebati, Mahamad B.、Kessel, David、Corbett, Thomas H.、et al.

  DOI：——

  日期：——
• A new class of artificial nucleases that recognize and cleave apurinic sites in DNA with great selectivity and efficiency
  作者：Abdellatif Fkyerat、Martine Demeunynck、Jean Francois Constant、Pierre Michon、Jean Lhomme

  DOI：10.1021/ja00075a011

  日期：1993.11

  A series of tailor-made molecules, 1 and 4-7, have been prepared to recognize and cleave DNA at apurinic sites. These molecules incorporate in their structure different units designed for specific functions: (1) an intercalator for DNA binding, (2) a nucleic base for abasic site recognition, and (3) a linker endowed with both a binding function and a cleavage function (Scheme II). The constituent units were varied successively in the series of molecules to get insight into their mode of action and prepare more active compounds. H-1 NMR spectroscopy reveals the absence of intramolecular ring-ring stacking interactions in water between the base and the intercalator in all molecules 1 and 4-7. All bind to calf thymus DNA with binding constants ranging from 10(4) to 10(6) M-1. Their nuclease activity was estimated by measuring their ability to induce single strand breaks in depurinated pBR 322 plasmid DNA. The most efficient molecule, 5, exhibits high recognition selectivity and cleavage efficiency: at nanomolar concentrations, 5 recognizes and cleaves the abasic lesion present in a DNA molecule containing an average of 1.8 apurinic sites in its 4 362 base pairs sequence. Molecule 5 exhibits higher cleaving efficiency than the reported tripeptide Lys-Trp-Lys: 10(-8) M concentrations of the former (5) lead to cleavage ratios comparable to those observed for the latter used as 10(-3) M concentration. This enzyme mimic 5 can be used advantageously as a substitute to the natural nuclease for in vitro cleavage of depurinated DNA.
• Holy, Antonin; Rosenberg, Ivan; Dvorakova, Hana, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 8, p. 2190 - 2210
  作者：Holy, Antonin、Rosenberg, Ivan、Dvorakova, Hana

  DOI：——

  日期：——

表征谱图