1-dodecanal hydrazone | 84941-27-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-dodecanal hydrazone
• 英文别名: Dodecanal hydrazone；Dodecylidenehydrazine
• CAS: 84941-27-5
• 化学式: C₁₂H₂₆N₂
• 分子量: 198.352
• InChiKey: DHSUWDICNGRMGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  38.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-dodecanal hydrazone 在 iodine monofluoride 作用下， 以 氯仿 为溶剂， 反应 1.0h， 以60%的产率得到1,1-Difluorododecane
  参考文献：
  名称：

  Conversion of the carbonyl group to CF2 using iodine monofluoride (IF)

  摘要：

  A novel method for the transformation of CO --> CF2 is described. The easily made hydrazone derivatives of the carbonyl moiety are reacted under mild conditions with IF prepared directly from the corresponding elements. Various hydrazones have been examined and compared with each other. Unsubstituted ones are usually the most suitable although they are not always easy to purify and store. N-Methyl- and N,N-dimethylhydrazones also give quite satisfactory results. The more easily made dinitrophenyl hydrazones (DNPs), semicarbazones, and tosylhydrazones also react, but the yields of the desired CF2 compounds are usually lower. Oximes could also be successfully reacted. The two main byproducts of the reaction are the parent carbonyl compounds, which can be recycled, and the alpha-iododifluoro derivatives. The latter upon treatment with LiAlH4 or Bu3SnH were reduced to the desired product, thus increasing the overall yields.

  DOI：

  10.1021/jo00015a024
• 作为产物：
  描述：

  十二醛 在 水 、 三乙胺 、 肼 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 1-dodecanal hydrazone
  参考文献：
  名称：

  1-碘-1-十二碳烯的均相催化氨基羰基化。通过钯催化的氨基羰基化轻松合成奇数个羧酰胺

  摘要：

  在（E）-和（Z）-1-碘-1-十二碳烯的钯催化的氨基羰基化反应中使用了包括甘氨酸甲酯在内的各种胺亲核试剂。底物是通过相应的从1-十二指肠合成的，,在四甲基胍的存在下用碘处理。均相催化氨基羰基化以中等至良好的产率产生了相应的奇数羧酰胺。该反应伴随有一些在2-位具有三键的羧酰胺的形成。后者的产物是用仲胺如哌啶和吗啉以相对高的收率形成的，并被分离为纯化合物。

  DOI：

  10.1016/j.tet.2008.08.022

文献信息

• [EN] USES OF HYDROPHOBICALLY-MODIFIED HYALURONIC ACID THROUGH AMIDE AND/OR HYDRAZIDE LINKAGES IN COSMETICS AND/OR DERMATOLOGY<br/>[FR] UTILISATIONS D'ACIDE HYALURONIQUE MODIFIÉ DE MANIÈRE HYDROPHOBE PAR DES LIAISONS AMIDE ET/OU HYDRAZIDE EN COSMÉTIQUE ET/OU EN DERMATOLOGIE
  申请人：BIOKAWTHAR TECH

  公开号：WO2018024902A1

  公开（公告）日：2018-02-08

  The present invention relates to the field of cosmetics and pharmaceuticals such as dermatology. Especially, the present invention relates to particles made of hyaluronic acid modified by amidation with hydrophobic groups having an amine or a hydrazine function having general formula (I), wherein Z, R and n are as defined in the claims. In particular, the particles of the invention are useful for restoring the endogenic production of hyaluronic acid and provide a lasting effect thanks to their slow degradation in vivo. The present invention also refers to a cosmetic care method comprising applying the particles of the invention on the skin of a subject in need thereof.