3,6-dihydroxy-2-naphthoic acid | 265309-30-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3,6-dihydroxy-2-naphthoic acid
• 英文别名: 3,6-dihydroxy-[2]naphthoic acid；3,6-Dihydroxy-[2]naphthoesaeure；3.6-Dioxy-naphthalin-carbonsaeure-(2)；3,6-Dihydroxy-naphthoesaeure-(2)；3,6-Dihydroxynaphthalene-2-carboxylic acid
• CAS: 265309-30-6
• 化学式: C₁₁H₈O₄
• 分子量: 204.182
• InChiKey: IXPJMUMWKOSEMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,6-dihydroxy-2-naphthoic acid 在 苯胺 作用下， 生成 6-anilino-3-hydroxy-[2]naphthoic acid
  参考文献：
  名称：

  Arylamides of 2,3-hydroxynaphthoic acids

  摘要：

  公开号：

  US02029509A1
• 作为产物：
  描述：

  2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-7-(methoxymethoxy)naphthalene 在 水 、 叔丁基锂 作用下， 以 甲醇 、 乙醚 、 正己烷 为溶剂， 反应 2.5h， 生成 3,6-dihydroxy-2-naphthoic acid
  参考文献：
  名称：

  The design, synthesis and activity of non-ATP competitive inhibitors of pp60c-src tyrosine kinase.Part 1: Hydroxynaphthalene derivatives

  摘要：

  A series of hydroxynaphthalene pp60(c-src) non-peptide inhibitors was designed, using the crystal structure of the insulin receptor tyrosine kinase as a qualitative model, to target the peptide substrate binding site. Representative inhibitors were shown to bind non-competitively with respect to ATP. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00039-1

文献信息

• Bicyclic compositions and methods for modulating a kinase cascade
  申请人：Hangauer David G.

  公开号：US20080004241A1

  公开（公告）日：2008-01-03

  The invention relates to compounds and methods for modulating one or more components of a kinase cascade.

  该发明涉及化合物和方法，用于调节激酶级联中的一个或多个组分。
• Protein kinase and phosphatase inhibitors and methods for designing them
  申请人：——

  公开号：US20030166615A1

  公开（公告）日：2003-09-04

  The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protein phosphatase inhibitors are provided. The protein kinase or protein phosphatase inhibitors of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, arthrosclerosis, immune system activity, Type II diabetes, and obesity.

  本发明提供了一种识别蛋白激酶和/或蛋白磷酸酶抑制剂的方法。还提供了用于抑制蛋白激酶和/或蛋白磷酸酶活性的方法。具体的非肽蛋白酪氨酸激酶和/或蛋白磷酸酶抑制剂也被提供。本发明的蛋白激酶或蛋白磷酸酶抑制剂可用于治疗患者的多种疾病，包括癌症、银屑病、动脉粥样硬化、免疫系统活性、2型糖尿病和肥胖症。
• Kinase inhibitors
  申请人：Hangauer G. David

  公开号：US20060089401A1

  公开（公告）日：2006-04-27

  The present invention provides a method for identifying inhibitors of protein kinases. Methods are also provided for inhibiting protein kinase activity. Specific non-peptide protein tyrosine kinase inhibitors are provided. The protein kinases produced using the method of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, atherosclerosis, or immune system activity.

  本发明提供了一种识别蛋白激酶抑制剂的方法。还提供了抑制蛋白激酶活性的方法。具体的非肽蛋白酪氨酸激酶抑制剂也被提供。使用本发明方法产生的蛋白激酶可用于治疗患者的多种疾病，包括癌症、牛皮癣、动脉粥样硬化或免疫系统活性。
• RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, AND COMPOUND
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20200183273A1

  公开（公告）日：2020-06-11

  A resist composition including a base material component (A) whose solubility in a developing solution is changed due to the action of an acid, and a compound (D0) formed of an anion moiety and a cation moiety which is represented by Formula (d0), in which the cation moiety of the compound (D0) has a Log P value of less than 7.7. In the formula, M m+ represents an m-valent organic cation, R d0 represents a substituent, p represents an integer of 0 to 3, q represents an integer of 0 to 3, n represents an integer of 2 or greater, and a relationship of “n+p≤(q×2)+5” is satisfied.

  一种抗蚀组合物，包括一种基材料组分（A），由于酸的作用而在显影液中溶解性发生改变，以及由阴离子基团和由公式（d0）表示的阳离子基团组成的化合物（D0）。其中，化合物（D0）的阳离子基团的Log P值小于7.7。在公式中，Mm+表示m价有机阳离子，Rd0表示取代基，p表示0到3之间的整数，q表示0到3之间的整数，n表示大于等于2的整数，并且满足“n+p≤（q×2）+5”的关系。
• [EN] PROTEIN KINASE AND PHOSPHATASE INHIBITORS, METHODS FOR DESIGNING THEM, AND METHODS OF USING THEM<br/>[FR] INHIBITEURS DE PROTEINES KINASES ET DE PROTEINES PHOSPHATASES, METHODES D'IDENTIFICATION ET METHODES D'UTILISATION ASSOCIEES
  申请人：UNIV NEW YORK STATE RES FOUND

  公开号：WO2003035621A1

  公开（公告）日：2003-05-01

  The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protein phosphatase inhibitors are provided. The protein kinase or protein phosphatase inhibitors of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, arthrosclerosis, immune system activity, diabetes, or obesity. In addition, the present invention provides a method for protecting against or treating hearing loss in a subject. This method involves administering an effective amount of a protein tyrosine kinase inhibitor to the subject to protect against or to treat hearing loss.

  本发明提供了一种识别蛋白激酶和/或蛋白磷酸酶抑制剂的方法。还提供了抑制蛋白激酶和/或蛋白磷酸酶活性的方法。提供了特定的非肽蛋白酪氨酸激酶和/或蛋白磷酸酶抑制剂。本发明的蛋白激酶或蛋白磷酸酶抑制剂可用于治疗患者的多种病症，包括癌症、牛皮癣、动脉硬化、免疫系统活动、糖尿病或肥胖症。此外，本发明提供了一种保护或治疗受试者听力损失的方法。该方法涉及向受试者投与有效量的蛋白酪氨酸激酶抑制剂以保护或治疗听力损失。