1-methyl-3H-imidazo[4,5-b]pyridine-2-thione | 120759-61-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 1-methyl-3H-imidazo[4,5-b]pyridine-2-thione
• CAS: 120759-61-7
• 化学式: C₇H₇N₃S
• 分子量: 165.219
• InChiKey: WEPJEJQCERADKL-UHFFFAOYSA-N

物化性质

• 熔点：
  234-235 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))
• 沸点：
  277.1±23.0 °C(Predicted)
• 密度：
  1.42±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-甲基-1H-咪唑并[4,5-b]吡啶 在 sulfur 作用下， 反应 0.58h， 以82%的产率得到1-methyl-3H-imidazo[4,5-b]pyridine-2-thione
  参考文献：
  名称：

  Thionation of imidazopyridines

  摘要：

  DOI：

  10.1007/bf00475602

文献信息

• BICYCLIC (THIO)CARBONYLAMIDINES
  申请人：BAYER INTELLECTUAL PROPERTY GMBH

  公开号：US20140113824A1

  公开（公告）日：2014-04-24

  Bicyclic (thio)carbonylamidines of the formula (I) in which Q, B, Y, R 1 and A are as defined in the description their preparation and their use for controlling plant pests and pests encountered in veterinary medicine.

  双环(thio)羰基脲类化合物的化学式为(I)，其中Q、B、Y、R1和A的定义详见说明书，本发明涉及其制备方法以及在控制植物害虫和兽医学中遇到的害虫中的应用。
• Imidazopyridine thioglycolic acid derivatives as potent inhibitors of human urate transporter 1
  申请人：SHANDONG UNIVERSITY

  公开号：US10399978B2

  公开（公告）日：2019-09-03

  It relates to the imidazopyridine thioglycolic acid derivatives, the preparation, and use thereof. The invention contained imidazopyridine thioglycolic acid derivatives with the formula I or II or III. Also described here are preparation of imidazopyridine thioglycolic acid derivatives, pharmaceutical compositions comprising these compounds as therapy and prevention for gout.

  本发明涉及咪唑吡啶硫代乙醇酸衍生物、其制备方法和用途。本发明包含式 I 或 II 或 III 的咪唑吡啶硫代乙醇酸衍生物。这里还描述了咪唑吡啶硫代乙醇酸衍生物的制备、包含这些化合物的药物组合物作为痛风的治疗和预防。
• YUTILOV, YU. M.;SVERTILOVA, I. A., XIMIYA GETEROTSIKL. SOED.,(1988) N 6, 799-804
  作者：YUTILOV, YU. M.、SVERTILOVA, I. A.

  DOI：——

  日期：——
• METHOD OF PREPARING LITHOGRAPHIC PRINTING PLATE
  申请人：Taguchi Yoshinori

  公开号：US20100081771A1

  公开（公告）日：2010-04-01

  A method for preparing a lithographic printing plate includes treating a lithographic printing plate precursor including a hydrophilic support and an image-forming layer containing the following (i) to (iii) with an aqueous solution having a buffering ability: (i) a binder polymer comprising a repeating unit having a structure represented by the following formula (1); (ii) an ethylenically unsaturated compound; and (iii) a polymerization initiator, P-L-(CO 2 H) n (1) wherein P represents a part constituting a main chain skeleton of the polymer, L represents an (n+1) valent connecting group, and n represents an integer of 1 or more.
• Novel Imidazopyridine Thioglycolic Acid Derivatives as Potent Inhibitors of Human Urate Transporter 1
  申请人：SHANDONG UNIVERSITY

  公开号：US20190225606A1

  公开（公告）日：2019-07-25

  It relates to the imidazopyridine thioglycolic acid derivatives, the preparation, and use thereof. The invention contained imidazopyridine thioglycolic acid derivatives with the formula I or II or III. Also described here are preparation of imidazopyridine thioglycolic acid derivatives, pharmaceutical compositions comprising these compounds as therapy and prevention for gout.