isoquinoline-5-thiol | 197511-90-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: isoquinoline-5-thiol
• 英文别名: 5-isoquinolinethiol
• CAS: 197511-90-3
• 化学式: C₉H₇NS
• 分子量: 161.227
• InChiKey: KSGDGKOVRPPSSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  13.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  isoquinoline-5-thiol 在 乙酸酐 作用下， 以 乙酸乙酯 为溶剂， 生成 6-(5-isoquinolylsulfanyl)-2-methylbenzo[d][1,3]oxazole
  参考文献：
  名称：

  US5959107

  摘要：

  公开号：
• 作为产物：
  描述：

  O-5-isoquinolyl dimethylthiocarbamate 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 6.0h， 生成 isoquinoline-5-thiol
  参考文献：
  名称：

  Studies on Anti-Helicobacter pylori Agents. Part 1: Benzyloxyisoquinoline Derivatives

  摘要：

  The synthesis and optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives that was discovered by a random screening process, are described. In the in vitro assay, compound 10c containing a 3-acetamido-2,6-dichlorobenzyl substituent was found to have extremely potent activity against H. pylori and no activity against other common bacteria. The anti-H. pylori activity of 10c was superior to that of amoxicillin (AMPC) (1) and clarithromycin (CAM) (2), However, 10c did not show in vivo efficacy in a mouse infection model; a feature attributed to the lack of strong bactericidal activity at short contact times. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00203-5

文献信息

• 一种利用连续流反应器制备取代苯硫酚及杂环硫酚的方法
  申请人：浙江扬帆新材料股份有限公司

  公开号：CN109096160A

  公开（公告）日：2018-12-28

  本发明涉及一种利用连续流反应器制备取代苯硫酚及杂环硫酚的方法，以苯酚及其衍生物或杂环酚为起始原料，经过氯代、酯化、重排和水解四步反应制备目标化合物，其中重排反应在连续流反应器中进行，该方法利用高温反应的小型化加热装置以及反应本身发热来保证反应的进行，在几十秒的短暂停留时间内就得到高于常规反应器中的转化率和收率，降低相关副反应的发生，同时反应过程中避免温度与浓度波动，无飞温与过热现象，反应过程安全可控。
• NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS
  申请人：SASAHARA Takehiko

  公开号：US20120015925A1

  公开（公告）日：2012-01-19

  A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substituent:

  提供了一种作为治疗剂和预防剂用于高脂血症的药物，以及一种作为治疗剂和预防剂用于与胆汁淤积相关的肝疾病，特别是原发性胆汁性肝硬化和原发性硬化性胆管炎的药物，以及一种作为治疗剂和预防剂用于肥胖症、脂肪肝和脂肪性肝炎的药物。该药物是一种具有硫酰胺键和季铵基取代基的苯并噻吩或苯并噻吩化合物，其化学式为（1A）。
• NOVEL ISOQUINOLINE DERIVATIVES
  申请人：SNOW BRAND MILK PRODUCTS CO., LTD.

  公开号：EP0855391A1

  公开（公告）日：1998-07-29

  Novel isoquinoline derivatives represented by general formula (I) or pharmaceutically acceptable acid-addition salts thereof, prepared by aiming at providing novel compounds which have an inhibitory activity on nerve cell death of the apoptosis type, wherein Ar represents an optionally substituted aromatic ring; and n is 0, 1 or 2. Because of the inhibitory effect on cell death, these compounds are useful as preventives and remedies for neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's chorea and amyotrophic lateral sclerosis, ischemic cerebral diseases such as cerebral stroke, and peripheral nerve disorders observed in diabetes, etc.

  通式(I)代表的新型异喹啉衍生物或其药学上可接受的酸加成盐，旨在提供对神经细胞凋亡具有抑制活性的新型化合物，其中Ar代表任选取代的芳环；n为0、1或2。由于对细胞死亡具有抑制作用，这些化合物可作为预防和治疗神经退行性疾病（如阿尔茨海默病、帕金森病、亨廷顿舞蹈症和肌萎缩性脊髓侧索硬化症）、缺血性脑疾病（如脑中风）和糖尿病引起的周围神经紊乱等的药物。
• ORGANIC LIGHT-EMITTING DEVICE
  申请人：Samsung Display Co., Ltd.

  公开号：EP3185328A1

  公开（公告）日：2017-06-28

  An organic light-emitting device comprising: a first electrode; a second electrode facing the first electrode; an emission layer between the first electrode and the second electrode; a hole transport region between the first electrode and the emission layer; and an electron transport region between the emission layer and the second electrode, wherein the emission layer comprises a first compound represented by one of selected from Formulae 1A to 1E, and at least one selected from the hole transport region and the electron transport region comprises a second compound represented by Formula 2A or 2B:

  一种有机发光器件，包括：第一电极；面向第一电极的第二电极；位于第一电极和第二电极之间的发射层；位于第一电极和发射层之间的空穴传输区域；以及位于发射层和第二电极之间的电子传输区域，其中发射层包括由式 1A 至 1E 中的一种所代表的第一化合物，而空穴传输区域和电子传输区域中的至少一种包括由式 2A 或 2B 所代表的第二化合物：
• DIAMINE COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：EP3561894A1

  公开（公告）日：2019-10-30

  Provided are a diamine compound including a naphthyl-phenyl linker and a 2-carbazolyl group and an organic light-emitting device including the same. The organic light-emitting device includes: a first electrode; a second electrode; and an organic layer between the first electrode and the second electrode and including an emission layer, wherein the organic layer includes the diamine compound including the naphthyl-phenyl linker and the 2-carbazolyl group.

  本发明提供了一种包括萘基-苯基连接体和 2-咔唑基团的二胺化合物，以及一种包括该二胺化合物的有机发光器件。有机发光器件包括：第一电极；第二电极；以及位于第一电极和第二电极之间并包括发射层的有机层，其中有机层包括二胺化合物，该二胺化合物包括萘基-苯基连接体和 2-咔唑基团。