N-(3,4-dihydro-5-oxa-1,2a-diaza-acenaphthylen-2-yl)-N-(4-trifluoromethyl-benzyl)-benzenesulfonamide | 1258460-57-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: N-(3,4-dihydro-5-oxa-1,2a-diaza-acenaphthylen-2-yl)-N-(4-trifluoromethyl-benzyl)-benzenesulfonamide
• 英文别名: N-(9-oxa-1,3-diazatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraen-2-yl)-N-[[4-(trifluoromethyl)phenyl]methyl]benzenesulfonamide
• CAS: 1258460-57-9
• 化学式: C₂₃H₁₈F₃N₃O₃S
• 分子量: 473.475
• InChiKey: IEJLXPLJOXCEDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  72.8
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N-(3,4-dihydro-5-oxa-1,2a-diaza-acenaphthylen-2-yl)-benzenesulfonamide 、 1-溴-三氟对二甲苯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 N-(3,4-dihydro-5-oxa-1,2a-diaza-acenaphthylen-2-yl)-N-(4-trifluoromethyl-benzyl)-benzenesulfonamide
  参考文献：
  名称：

  BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS

  摘要：

  揭示了用于治疗各种疾病、综合症、症状和障碍的化合物、组合物和方法，包括疼痛。这些化合物由以下的化学式I表示：其中R0、R1、R2、R3、R4和a在此有定义。

  公开号：

  US20110003801A1

文献信息

• Benzimidazole derivatives useful as TRPM8 channel modulators
  申请人：Janssen Pharmaceutica NV

  公开号：US08242157B2

  公开（公告）日：2012-08-14

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.

  本发明涉及用于治疗各种疾病、综合症、病症和障碍，包括疼痛的化合物、组合物和方法。这些化合物由以下式子I表示：其中R0、R1、R2、R3、R4和a在此定义。
• US8242157B2
  申请人：——

  公开号：US8242157B2

  公开（公告）日：2012-08-14
• [EN] BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS<br/>[FR] DÉRIVÉS DE BENZIMIDAZOLE MODULATEURS DU CANAL TRPM8
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2010144680A1

  公开（公告）日：2010-12-16

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows wherein R0, R1, R2, R3, R4 and a are defined herein. The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and condition modulated by the TRPM8 (transient receptor potential melastatin subfamily type 8) channel. The present invention also relates to processes for the preparation of benzimidazole derivatives and to their use in treating various diseases, syndromes, and disorders, including, those that cause inflammatory pain, neuropathic pain, cardiovascular diseases aggravated by cold, pulmonary diseases aggravated by cold,, and combinations thereof.
• BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS
  申请人：Jetter Michele C.

  公开号：US20110003801A1

  公开（公告）日：2011-01-06

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R 0 , R 1 , R 2 , R 3 , R 4 and a are defined herein.

  揭示了用于治疗各种疾病、综合症、症状和障碍的化合物、组合物和方法，包括疼痛。这些化合物由以下的化学式I表示：其中R0、R1、R2、R3、R4和a在此有定义。