stilben-α-ylamine | 35129-64-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: stilben-α-ylamine
• 英文别名: Stilben-α-ylamin；N-benzylidenebenzylimine；(Z)-1,2-diphenylethenamine
• CAS: 35129-64-7
• 化学式: C₁₄H₁₃N
• 分子量: 195.264
• InChiKey: XFLTXYRMEZIEOG-KAMYIIQDSA-N

物化性质

• 沸点：
  327.1±31.0 °C(Predicted)
• 密度：
  1.086±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  stilben-α-ylamine 、 乙酸酐 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Krabbe; Schmidt; Eisenlohr, Chemische Berichte, 1941, vol. 74, p. 1905,1910

  摘要：

  DOI：
• 作为产物：
  描述：

  苯甲腈 、 苄基氯化镁 在 乙醚 作用下， 生成 stilben-α-ylamine
  参考文献：
  名称：

  Phenylbenzyl Ketimine and Derivatives¹

  摘要：

  DOI：

  10.1021/ja01289a080

文献信息

• STILBENE DERIVATIVES AS NEW CANCER THERAPEUTIC AGENTS
  申请人：Lee Ruey-min

  公开号：US20080261982A1

  公开（公告）日：2008-10-23

  Stilbene derivatives exhibit killing and suppression of growth activity against a variety of cancer cells, and are effective at suppressing tumor growth in vivo. The stilbene derivatives may be used in the treatment of diseases characterized by cell hyperproliferation including human malignancies and non-malignant diseases such as liver cirrhosis. Stilbenes may also disrupt abnormal vessels in tumor to achieve vascular disrupting effect to suppress tumor growth. Water soluble pro-drug forms of stilbene derivatives are particularly useful in suppressing tumor growth in vivo.

  Stilbene衍生物表现出对多种癌细胞的杀灭和抑制生长活性，并且在体内有效地抑制肿瘤生长。Stilbene衍生物可用于治疗以细胞过度增殖为特征的疾病，包括人类恶性肿瘤和非恶性疾病，如肝硬化。Stilbenes也可以破坏肿瘤中的异常血管，实现血管破坏效应以抑制肿瘤生长。水溶性的Stilbene衍生物前药形式在体内抑制肿瘤生长方面特别有用。
• [EN] MANGANESE BASED COMPLEXES AND USES THEREOF FOR HOMOGENEOUS CATALYSIS<br/>[FR] COMPLEXES À BASE DE MANGANÈSE ET LEURS UTILISATIONS SERVANT À UNE CATALYSE HOMOGÈNE
  申请人：YEDA RES & DEV

  公开号：WO2017137984A1

  公开（公告）日：2017-08-17

  The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C-C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di- lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

  本发明涉及新型锰配合物及其用途，包括但不限于在以下领域进行均相催化：（1）通过醇和胺的脱氢偶联制备亚胺；（2）使用腈作为迈克尔供体进行迈克尔加成反应中的C-C偶联；（3）将醇脱氢偶联以得到酯和氢气；（4）将酯加氢以形成醇（包括环酯（内酯）或环二酯（二内酯）或聚酯的加氢）；（5）将酰胺（包括环二肽、内酰胺、二酰胺、多肽和聚酰胺）加氢以得到醇和胺（或二胺）；（6）将有机碳酸酯（包括聚碳酸酯）加氢以得到醇或将氨基甲酸酯（包括聚氨基甲酸酯）或脲衍生物加氢以得到醇和胺；（7）将二级醇脱氢以得到酮；（8）酯的酰胺化（即从酯和胺合成酰胺）；（9）使用酯对醇进行酰化；（10）将醇与水和碱偶联以形成羧酸；以及（11）通过氨基醇与水和碱的偶联制备氨基酸或其盐。（12）通过醇和胺的脱氢偶联制备酰胺（包括甲酰胺、环二肽、二酰胺、内酰胺、多肽和聚酰胺）；（13）从二醇制备酰亚胺。
• Benzoyl-substituted phenylalanineamides
  申请人：Witschel Matthias

  公开号：US20070142230A1

  公开（公告）日：2007-06-21

  The present invention relates to benzoyl-substituted phenylalanineamides of the formula I in which the variables R 1 to R 15 are as defined in the description, and to their agriculturally useful salts, to processes and intermediates for their preparation and to the use of these compounds or of compositions comprising these compounds for controlling unwanted plants.

  本发明涉及式I的苯甲酰基取代苯丙氨酰胺，其中变量R1到R15如描述中所定义，以及它们在农业上有用的盐，用于它们的制备的过程和中间体，以及这些化合物或含有这些化合物的组合物用于控制不受欢迎的植物。
• [EN] PROCESS FOR PREPARING AMINES FROM ALCOHOLS AND AMMONIA<br/>[FR] PROCÉDÉ POUR LA FABRICATION D'AMINES À PARTIR D'ALCOOLS ET D'AMMONIAC
  申请人：YEDA RES & DEV

  公开号：WO2010018570A1

  公开（公告）日：2010-02-18

  The present invention provides novel ruthenium based catalysts, and a process for preparing amines, by reacting a primary alcohol and ammonia in the presence of such catalysts, to generate the amine and water. According to the process of the invention, primary alcohols react directly with ammonia to produce primary amines and water in high yields and high turnover numbers. This reaction is catalyzed by novel ruthenium complexes, which are preferably composed of quinolinyl or acridinyl based pincer ligands.

  本发明提供了新型基于钌的催化剂，以及一种制备胺的方法，通过在这些催化剂的存在下，将一级醇和氨反应，生成胺和水。根据本发明的方法，一级醇直接与氨反应，产生高产率和高周转数的一级胺和水。该反应由新型钌配合物催化，该配合物最好由喹啉基或吖啶基的夹夹配体组成。
• Heteroaroyl-substituted phenylalanineamides
  申请人：Witschel Matthias

  公开号：US20070060480A1

  公开（公告）日：2007-03-15

  Pyrazolylcarbonyl-substituted phenylalanineamides of the formula I in which the variables A and R 1 to R 10 are as defined in the description, and their agriculturally useful salts, processes and intermediates for their preparation; and the use of these compounds or of compositions comprising these compounds for controlling unwanted plants are described.

  公式I中的吡唑基羰基取代的苯丙氨酰胺，其中变量A和R1到R10如描述中所定义，以及它们的农业有用盐、制备它们的过程和中间体；以及描述了这些化合物或含有这些化合物的组合物用于控制不受欢迎的植物。