7-chloro-3-ethylimidazo[1,2-a]pyridine-8-carbonitrile | 1208220-54-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 7-chloro-3-ethylimidazo[1,2-a]pyridine-8-carbonitrile
• CAS: 1208220-54-5
• 化学式: C₁₀H₈ClN₃
• 分子量: 205.647
• InChiKey: ZQNKSQIEVNESPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.42
• 重原子数：
  14.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  41.09
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1-(2-嘧啶基)哌嗪 、 7-chloro-3-ethylimidazo[1,2-a]pyridine-8-carbonitrile 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 0.25h， 生成 3-Ethyl-7-(4-pyrimidin-2-ylpiperazin-1-yl)imidazo[1,2-a]pyridine-8-carbonitrile
  参考文献：
  名称：

  Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

  摘要：

  Imidazo[1,2-a] pyridines were identidied via their shape and electrostatic similarity as novel positive allosteric modulators of the metabotropic glutamate 2 receptor. The subsequent synthesis and SAR are described. Potent, selective and metabolically stable compounds were found representing a promising avenue for current further studies. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.008
• 作为产物：
  描述：

  3-ethyl-7-hydroxyimidazo[1,2-a]pyridine-8-carbonitrile 在 三氯氧磷 作用下， 反应 0.25h， 生成 7-chloro-3-ethylimidazo[1,2-a]pyridine-8-carbonitrile
  参考文献：
  名称：

  Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

  摘要：

  Imidazo[1,2-a] pyridines were identidied via their shape and electrostatic similarity as novel positive allosteric modulators of the metabotropic glutamate 2 receptor. The subsequent synthesis and SAR are described. Potent, selective and metabolically stable compounds were found representing a promising avenue for current further studies. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.008