2-{[4-allylamino-6-(R)-(1-(1-naphthyl)ethylamino)-1,3,5-triazin-2-yl]oxy}ethylamine | 479623-53-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-{[4-allylamino-6-(R)-(1-(1-naphthyl)ethylamino)-1,3,5-triazin-2-yl]oxy}ethylamine
• CAS: 479623-53-5
• 化学式: C₂₀H₂₄N₆O
• 分子量: 364.45
• InChiKey: UVVIFYFNLPINJO-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.13
• 重原子数：
  27.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  97.98
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  2-{[4-allylamino-6-(R)-(1-(1-naphthyl)ethylamino)-1,3,5-triazin-2-yl]oxy}ethylamine 在 偶氮二异丁腈 、 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 66.0h， 生成
  参考文献：
  名称：

  Biselector enantioselective stationary phases for HPLC: dependence of the chiral discrimination properties on stereochemistry and chemical nature of each unit of the chiral auxiliary

  摘要：

  Optically active 1-(1-naphthyl)ethylamine, N-3,5-dinitrobenzoylphenylglycine and N-3,5-dinitrobenzoylleucine were used as chiral building blocks to prepare three new enantiomerically pure bifunctional chiral auxiliaries for enantioselective HPLC, belonging to a family of biselector systems, the first example of which (CSP1) has been described previously. These compounds were covalently linked to silica gel to produce three chiral stationary phases (CSPs 2-4), whose enantiodiscriminating capability towards the HPLC resolution of selected racemic compounds was assessed. The obtained results allowed us to establish the influence of the stereochemistry and/or the chemical structure of each chiral moiety of the biselector system on their enantiorecognition properties. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00402-0
• 作为产物：
  描述：

  [2-(4,6-Dichloro-[1,3,5]triazin-2-yloxy)-ethyl]-carbamic acid tert-butyl ester 在 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 生成 2-{[4-allylamino-6-(R)-(1-(1-naphthyl)ethylamino)-1,3,5-triazin-2-yl]oxy}ethylamine
  参考文献：
  名称：

  Biselector enantioselective stationary phases for HPLC: dependence of the chiral discrimination properties on stereochemistry and chemical nature of each unit of the chiral auxiliary

  摘要：

  Optically active 1-(1-naphthyl)ethylamine, N-3,5-dinitrobenzoylphenylglycine and N-3,5-dinitrobenzoylleucine were used as chiral building blocks to prepare three new enantiomerically pure bifunctional chiral auxiliaries for enantioselective HPLC, belonging to a family of biselector systems, the first example of which (CSP1) has been described previously. These compounds were covalently linked to silica gel to produce three chiral stationary phases (CSPs 2-4), whose enantiodiscriminating capability towards the HPLC resolution of selected racemic compounds was assessed. The obtained results allowed us to establish the influence of the stereochemistry and/or the chemical structure of each chiral moiety of the biselector system on their enantiorecognition properties. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00402-0