3,4,5-trihydroxyphenethyl alcohol | 134695-79-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3,4,5-trihydroxyphenethyl alcohol
• 英文别名: 5-(2-hydroxyethyl)benzene-1,2,3-triol
• CAS: 134695-79-7
• 化学式: C₈H₁₀O₄
• 分子量: 170.165
• InChiKey: BKCBZRVGJIVNRL-UHFFFAOYSA-N

物化性质

• 沸点：
  436.5±40.0 °C(Predicted)
• 密度：
  1.479±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对羟基苯乙醇 在 盐酸 、 potassium peroxymonosulfate 、 三溴化硼 、 碳酸二甲酯 、 sodium bromide 、 copper(I) bromide 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 28.0h， 生成 3,4,5-trihydroxyphenethyl alcohol
  参考文献：
  名称：

  Synthesis and biological evaluation of gallic acid analogs

  摘要：

  A novel and efficient synthesis of pyrogallol moiety through a copper(I)-mediated C-O bond forming reaction is described. In particular, syntheses of 3,4,5-trihydroxyphenethyl alcohol and its methyl derivative are reported. Particular attention to dimethyl carbonate as an eco-friendly solvent/reactant has been paid, in order to improve the eco-compatibility of the whole synthetic pathway. Furthermore, the genotoxicity, cytotoxicity and the antioxidant activity of 3,4,5-trihydroxyphenethyl alcohol and its methyl derivative have been investigated.

  DOI：

  10.1007/s00044-012-0052-8

文献信息

• Topical Delivery System for Antiaging and Skin Whitening Agents
  申请人：GUPTA SHYAM K.

  公开号：US20090074691A1

  公开（公告）日：2009-03-19

  This invention relates to certain hydroxyaryl alkanols, alkyl amines, alkyl amino acids, alkyl amino esters, and alkyl amino alkanols (“Hydroxyaryl compounds”) of formula (I). A method of topical application of said hydroxyaryl compounds is also disclosed. The treatment of certain enzyme dysfunctions that cause skin or hair condition such as darkened skin including age spots, dark circles around the eyes, and discoloration of skin from stretch marks; skin conditions related to acne including excess facial oil and facial pore size; premature hair aging including hair loss and graying; inflammation including intra-cellular and extra-cellular inflammation; skin aging including wrinkles and fine lines; loss of collagen including thinning skin and loss of skin pliability; malfunction of tyrosinase group of enzymes; and malfunction of matrix metalloprotease group of enzymes with said hydroxyaryl compounds is also disclosed:

  本发明涉及公式（I）的某些羟基芳基丙醇、烷基胺、烷基氨基酸、烷基氨基酯和烷基氨基丙醇（“羟基芳基化合物”）。还公开了一种使用上述羟基芳基化合物的局部应用方法。本发明还公开了使用上述羟基芳基化合物治疗某些酶功能障碍，这些酶功能障碍导致皮肤或头发状况的异常，例如黑化的皮肤，包括老年斑、眼周黑眼圈和妊娠纹引起的皮肤色素沉着；与痤疮相关的皮肤状况，包括过多的面部油脂和面部毛孔大小；过早的头发老化，包括脱发和白发；炎症，包括细胞内和细胞外炎症；皮肤衰老，包括皱纹和细纹；胶原蛋白流失，包括皮肤变薄和失去弹性；酪氨酸酶类酶的功能障碍；以及基质金属蛋白酶类酶的功能障碍。
• Branched polycarbonates and method of preparation
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0400478A2

  公开（公告）日：1990-12-05

  Branched polycarbonates are prepared by melt equilibration of aromatic cyclic polycarbonate oligomers with a polyhydric phenol having more than two hydroxy groups per molecule, preferably 1,1,1-tris-(4-hydroxyphenyl)ethane, in the presence of a carbonate equilibration catalyst, preferably tetrabutylammonium tetraphenylborate. In an additional embodiment of the invention, a linear aromatic polycarbonate is added to the reaction mixture. Branched polycarbonates prepared according to this invention have high melt strength and high shear sensitivity characteristics and are useful in extrusion and injection molding processing applications and particularly useful in blow molding applications for preparing relatively large articles and panels.

  支链聚碳酸酯的制备方法是，在碳酸盐平衡催化剂（最好是四苯基硼酸四丁基铵）存在下，芳香族环状聚碳酸酯低聚物与每分子具有两个以上羟基的多水酚（最好是 1,1,1-三（4-羟基苯基）乙烷）进行熔融平衡。在本发明的另一个实施方案中，向反应混合物中加入线性芳香族聚碳酸酯。根据本发明制备的支链聚碳酸酯具有高熔体强度和高剪切敏感性的特点，可用于挤出和注塑成型加工应用，尤其适用于吹塑成型应用，以制备相对较大的制品和面板。
• Compounds, compositions and methods for coloring edible materials
  申请人：The Penn State Research Foundation

  公开号：US11001601B2

  公开（公告）日：2021-05-11

  The present invention provides compounds isolated from avocado seeds for use as a natural colorant in edible materials. The compounds of the invention are useful for coloring edible materials red, orange or yellow. The invention also provides compositions and methods for coloring edible materials to a desired color such as red, orange or yellow.

  本发明提供了从鳄梨种子中分离出来的化合物，可用作食用材料中的天然着色剂。本发明的化合物可用于将食用材料染成红色、橙色或黄色。本发明还提供了将食用材料着色为红色、橙色或黄色等所需颜色的组合物和方法。
• Production of branched polycarbonates by an equilibration process
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0708130B1

  公开（公告）日：2003-09-10
• VERFAHREN ZUR HERSTELLUNG VON VERZWEIGTEN POLYCARBONATEN
  申请人：Bayer MaterialScience AG

  公开号：EP0993481B1

  公开（公告）日：2008-03-05