| 157232-80-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• CAS: 157232-80-9
• 化学式: C₁₆H₁₈O₄
• 分子量: 274.317
• InChiKey: CKVUBGXXTSCDBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.37
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  55.76
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  对羟基苯乙醇 在 Trametes trogii laccase 作用下， 以 aq. phosphate buffer 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Enzymatic transformation of tyrosol by Trametes trogii laccases: Identification of the product and study of its biological activities

  摘要：

  Oxidative transformation of tyrosol catalysed by Trametes trogii laccases in aqueous solution was investigated. LC-MS analysis shows that tyrosol was converted to its dimer. The enzymatic reaction was also investigated by H-1 and C-13 nuclear magnetic resonance, and the product formed was identified as a dimeric tetracyclic ketone. The bactericidal and fungicidal properties of tyrosol dimer were investigated using the NCCLS broth dilution and EN 1276 standard methods. High bactericidal and fungicidal effect of concentrations ranged between 1-0.5 g L-1 and 8-4 g L-1 were obtained. Dimer concentrations of 33 g L-1 and 66 g L-1 allowed reductions in viability higher than 5 log units per mL for Pseudomonas aeruginosa ATCC 15442, Escherichia coli ATCC 10536 and Enterococcus hirae ATCC 10541, Staphylococcus aureus ATCC 9144 respectively, within a contact time of 5 min under dirty conditions. The effect of this product on Tuta absoluta, a harmful pest of tomato in the world, was also evaluated. The results showed high insecticidal activity against this insect at a concentration of 16.5 g L-1. Germinability experiments on Lycopersicum esculetum were conducted in order to evaluate the potential of a laccase treatment in removing tyrosol phytotoxicity. The results showed that tyrosol dimer was nonphytotoxic. This study presents the first comprehensive results of biological characterisation of the product obtained by the action of laccase on tyrosol transformation with T. trogii laccases. (c) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcatb.2012.10.006