7-methoxy-3-methyl-1-[2-(4-([(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methyl]amino)piperidin-1-yl)ethyl]quinazoline-2,4(1H,3H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-methoxy-3-methyl-1-[2-(4-([(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methyl]amino)piperidin-1-yl)ethyl]quinazoline-2,4(1H,3H)-dione
• 英文别名: 7-methoxy-3-methyl-1-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]piperidin-1-yl]ethyl]quinazoline-2,4-dione
• 化学式: C₂₅H₃₀N₆O₅
• 分子量: 494.55
• InChiKey: VLGFXEZYUQJTFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1-[2-(4-aminopiperidin-1-yl)ethyl]-7-methoxyquinazoline-2,4(1H,3H)-dione trifluoroacetate 在 N,N-二异丙基乙胺 作用下， 以 甲醇 、 1,2-二氯乙烷 为溶剂， 反应 22.5h， 生成 7-methoxy-3-methyl-1-[2-(4-([(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methyl]amino)piperidin-1-yl)ethyl]quinazoline-2,4(1H,3H)-dione
  参考文献：
  名称：

  WO2006/134378

  摘要：

  公开号：

文献信息

• COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS
  申请人：Breault Gloria

  公开号：US20110092495A1

  公开（公告）日：2011-04-21

  The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.

  本发明涉及表现出抗菌活性的化合物，其制备过程，含有它们作为活性成分的制药组合物，它们作为药物的使用以及它们在制造用于治疗温血动物（如人类）细菌感染的药物中的使用。特别是本发明涉及用于治疗温血动物（如人类）细菌感染的有用化合物，更具体地涉及这些化合物在制造用于治疗温血动物（如人类）细菌感染的药物中的使用。
• Compounds for the treatment of multi-drug resistant bacterial infections
  申请人：AstraZeneca AB

  公开号：EP2289890A1

  公开（公告）日：2011-03-02

  The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.

  本发明涉及具有抗菌活性的化合物、制备这些化合物的工艺、含有这些化合物作为活性成分的药物组合物、这些化合物作为药物的用途以及这些化合物在制造用于治疗温血动物（如人类）细菌感染的药物中的用途。特别是本发明涉及用于治疗温血动物（如人类）细菌感染的化合物，尤其是涉及这些化合物在制造用于治疗温血动物（如人类）细菌感染的药物中的用途。
• US7875715B2
  申请人：——

  公开号：US7875715B2

  公开（公告）日：2011-01-25
• US8124602B2
  申请人：——

  公开号：US8124602B2

  公开（公告）日：2012-02-28
• WO2006/134378
  申请人：——

  公开号：——

  公开（公告）日：——