FD1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: FD1
• 英文别名: 3',6'-Bis(diethylamino)-2-(propan-2-ylideneamino)spiro[isoindoline-1,9'-xanthen]-3-one；3',6'-bis(diethylamino)-2-(propan-2-ylideneamino)spiro[isoindole-3,9'-xanthene]-1-one
• 化学式: C₃₁H₃₆N₄O₂
• 分子量: 496.652
• InChiKey: DGHAXKHRTURHND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  溶剂红 49 在 肼 、 三氯氧磷 作用下， 以 乙腈 为溶剂， 反应 4.5h， 生成 FD1
  参考文献：
  名称：

  A selective turn-on fluorescent sensor for FeIII and application to bioimaging

  摘要：

  A novel compound FDI was demonstrated as a turn-on fluorescent sensor for imaging of iron(III) ion in biological samples. Based on the spirolactam (nonfluorescence) to ring-open amide (fluorescence) equilibrium, FDI exhibited high selectivity and sensitivity for Fe3+ over other metal ions. Moreover, fluorescent microscopy experiments further established that FDI could be used for sensing Fe3+ within living cells. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.03.112

文献信息

• A selective turn-on fluorescent sensor for FeIII and application to bioimaging
  作者：Meng Zhang、Yanhong Gao、Manyu Li、Mengxiao Yu、Fuyou Li、Lei Li、Minwei Zhu、Jianping Zhang、Tao Yi、Chunhui Huang

  DOI：10.1016/j.tetlet.2007.03.112

  日期：2007.5

  A novel compound FDI was demonstrated as a turn-on fluorescent sensor for imaging of iron(III) ion in biological samples. Based on the spirolactam (nonfluorescence) to ring-open amide (fluorescence) equilibrium, FDI exhibited high selectivity and sensitivity for Fe3+ over other metal ions. Moreover, fluorescent microscopy experiments further established that FDI could be used for sensing Fe3+ within living cells. (c) 2007 Elsevier Ltd. All rights reserved.