1-[2-[Bis[(2-methylpropan-2-yl)oxy]-oxidophosphaniumyl]oxyethyl]-4-methoxybenzene | 1314357-88-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-[2-[Bis[(2-methylpropan-2-yl)oxy]-oxidophosphaniumyl]oxyethyl]-4-methoxybenzene
• 英文别名: 1-[2-[bis[(2-methylpropan-2-yl)oxy]-oxidophosphaniumyl]oxyethyl]-4-methoxybenzene
• CAS: 1314357-88-4
• 化学式: C₁₇H₂₉O₅P
• 分子量: 344.388
• InChiKey: GWQBCZZQFHYMIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  60
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 双氧水 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 1-[2-[Bis[(2-methylpropan-2-yl)oxy]-oxidophosphaniumyl]oxyethyl]-4-methoxybenzene
  参考文献：
  名称：

  Phosphonate-free phosphorylation of alcohols using bis-(tert-butyl) phosphoramidite with imidazole·hydrochloride and imidazole as the activator

  摘要：

  A variety of commercially available alcohols were converted to their bis-(tert-butyl) protected monophosphate pro-drugs. The improved procedure uses the unique combination of imidazole center dot hydrochloride and imidazole as the activator to suppress the formation of undesired phosphonate by-product frequently encountered with the bis-(tert-butyl) phosphoramidite reagents. The new activation procedure eliminates the need to use excess reagents. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.020

文献信息

• Phosphonate-free phosphorylation of alcohols using bis-(tert-butyl) phosphoramidite with imidazole·hydrochloride and imidazole as the activator
  作者：Bruno Haché、Lisa Brett、Sagar Shakya

  DOI：10.1016/j.tetlet.2011.05.020

  日期：2011.7

  A variety of commercially available alcohols were converted to their bis-(tert-butyl) protected monophosphate pro-drugs. The improved procedure uses the unique combination of imidazole center dot hydrochloride and imidazole as the activator to suppress the formation of undesired phosphonate by-product frequently encountered with the bis-(tert-butyl) phosphoramidite reagents. The new activation procedure eliminates the need to use excess reagents. (C) 2011 Elsevier Ltd. All rights reserved.