5-endo-(methylsulfonyl)-2-norbornene | 139689-82-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 5-endo-(methylsulfonyl)-2-norbornene
• 英文别名: (+/-)-methyl-norborn-5-ene-2endo-yl sulfone；(+/-)-Methyl-norborn-5-en-2endo-yl-sulfon；endo-5-Methylsulfonylbicyclo<2.2.1>hept-2-en；(1R,4R,5R)-5-methylsulfonylbicyclo[2.2.1]hept-2-ene
• CAS: 139689-82-0
• 化学式: C₈H₁₂O₂S
• 分子量: 172.248
• InChiKey: UYGRWJZJHMOECX-GJMOJQLCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.0
• 重原子数：
  11.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  34.14
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  5-endo-(methylsulfonyl)-2-norbornene 在 咪唑 、 草酰氯 、 双氧水 、 二异丁基氢化铝 、 二甲基亚砜 、 三乙胺 、 diborane(6) 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 、 苯 为溶剂， 反应 122.25h， 生成 6-endo-(methylthio)bicyclo[2.2.1]heptan-2-one
  参考文献：
  名称：

  A new synthesis of 2-substituted 6-endo-(methylthio)bicyclo[2.2.1]heptanes. Synthesis and crystal and molecular structure of a conformationally restricted methionine analog

  摘要：

  A new and advantageous synthesis of 2-endo-substituted-6-endo-(methylthio)bicyclo[2.2.1]heptanes, especially suitable for the preparation of such compounds with 2-endo-hydroxy and amino substituents, is presented. Also reported is the synthesis of the conformationally restricted methionine analogue (+/-)-2-endo-amino-6-endo-(methylthio)bicyclo[2.2.1]heptane-2-exo-carboxylic acid and its crystal and molecular structure determined by X-ray crystallographic techniques.

  DOI：

  10.1021/jo00035a026
• 作为产物：
  描述：

  环戊二烯 、 甲基乙烯砜 生成 5-endo-(methylsulfonyl)-2-norbornene
  参考文献：
  名称：

  Preparation of the Diels-Alder adducts of methyl vinyl sulfone and cyclopentadiene and of their dihydro derivatives

  摘要：

  DOI：

  10.1021/jo00799a048

文献信息

• Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes
  作者：Gary H. Posner、C.-G. Cho、Julianne V. Green、Yuesheng Zhang、Paul Talalay

  DOI：10.1021/jm00027a021

  日期：1994.1

  Thirty-five bifunctional isothiocyanates were synthesized as structural analogs of sulforaphane [(-)-l-isothiocyanato-4(R)-(methylsulfinyl)butane] that was recently isolated from broccoli as the principal and very potent inducer of detoxication (phase 2) enzymes in mouse tissues and murine hepatoma cells (Hepa 1c1c7) in culture (Zhang, Y.; Talalay, P.; Cho, C.-G.; Posner, G. Il. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 2399-2403). Determination of the potency of each analog in inducing NAD(P)H:quinone reductase, a phase 2 detoxication enzyme, has allowed generalizations concerning the relation of structure and activity. The most potent analogs were bifunctional derivatives in which the isothiocyanate group was separated from a methylsulfonyl or an acetyl group by three or four carbon atoms, and in some of which these groups were conformationally restricted. Among these analogs, the bicyclic ketoisothiocyanate (+/-)-exo-2-acetyl-6-isothiocyanatonorbornane (30) was a very potent inducer (comparable to sulforaphane) of quinone reductase in hepatoma cells, and it also induced both quinone reductase and glutathione transferases in several mouse organs in vivo. This and related bicyclic ketoisothiocyanates represent potent phase 2 enzyme inducers that are relatively easily synthesized and that may be more stable metabolically than the natural sulfoxide sulforaphane.
• Diels-Alder Reactions of α,β-Unsaturated Sulfonyl Compounds
  作者：H. R. Snyder、Hugh V. Anderson、Donald P. Hallada

  DOI：10.1021/ja01151a077

  日期：1951.7
• Posner Gary H., Cho Cheon-Gyu, Green Julianne V., Zhang Yuesheng, Talalay+, J. Med. Chem, 37 (1994) N 1, S 170-176
  作者：Posner Gary H., Cho Cheon-Gyu, Green Julianne V., Zhang Yuesheng, Talalay+

  DOI：——

  日期：——