1-piperazine hexanol | 5625-62-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-piperazine hexanol
• 英文别名: 6-Piperazino-hexanol-1；6-piperazin-1-yl-hexan-1-ol；6-Piperazin-1-ylhexan-1-ol
• CAS: 5625-62-7
• 化学式: C₁₀H₂₂N₂O
• 分子量: 186.297
• InChiKey: RMIIQABTVWHYKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-piperazine hexanol 在 亚硝酸特丁酯 作用下， 以 乙醇 为溶剂， 以89%的产率得到6-(4-Nitroso-piperazin-1-yl)-hexan-1-ol
  参考文献：
  名称：

  Application of Piperazine-Derived Hydrazone Linkers for Alkylation of Solid-Phase Immobilized Ketones

  摘要：

  本文描述了三种新型固体支架的制备和应用，这些支架具有源自哌嗪的肼锚定基团。所述支架用于酮的固定化。酮包括环己酮、4-叔丁基环己酮、3-戊酮和托品酮，这些酮以肼酮的形式与聚合物结合，经过LDA去质子化后，用丙基碘或苄基溴进行烷基化。得到的烷基化产物用三氟乙酸在二氯甲烷中处理后从固体支架上断裂。具有6个和3个碳原子间隔的连接器效果优于简单的N-氨基哌嗪连接器。

  DOI：

  10.1055/s-2002-34879
• 作为产物：
  描述：

  tert-butyl 4-(6-ethoxy-6-oxohexyl)piperazine-1-carboxylate 在 硼烷四氢呋喃络合物 、 盐酸 、 水 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 28.0h， 生成 1-piperazine hexanol
  参考文献：
  名称：

  NOVEL ARYLAMIDINE DERIVATIVE OR SALT THEREOF

  摘要：

  公开号：

  EP1481966B1

文献信息

• 2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION
  申请人：Wakamoto Pharmaceutical Co., Ltd.

  公开号：EP1820799A1

  公开（公告）日：2007-08-22

  The present invention has its object to provide a 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented with the Formula (1) , or the pharmaceutically acceptable salt, which is effective as a therapeutic and prophylactic agent for diabetes, diabetic nephropathy, or glomerulosclerosis.

  本发明的目的是提供一种用化学式（1）表示的2,3,4,5-四氢-1H-1,5-苯二氮䓬衍生物，或其药学上可接受的盐，作为治疗和预防糖尿病、糖尿病肾病或肾小球硬化的药剂。
• Application of Piperazine-Derived Hydrazone Linkers for Alkylation of Solid-Phase Immobilized Ketones
  作者：Ryszard Lazny、Michal Michalak

  DOI：10.1055/s-2002-34879

  日期：——

  The preparation and application of three new solid supports with piperazine-derived hydrazine anchoring groups are described. The supports were used for immobilization of ketones. The ketones: cyclohexanone, 4-tert-butylcyclohexanone, 3-pentanone and tropinone, which were bound to polymers in the form of their hydrazones, were deprotonated with LDA and alkylated with propyl iodide or benzyl bromide. The resulting alkylated products were cleaved off the solid support on treatment with trifluoroacetic acid in dichloromethane. Linkers with 6- and 3-carbon atom spacers gave better results than the simple N-aminopiperazine linker.

  本文描述了三种新型固体支架的制备和应用，这些支架具有源自哌嗪的肼锚定基团。所述支架用于酮的固定化。酮包括环己酮、4-叔丁基环己酮、3-戊酮和托品酮，这些酮以肼酮的形式与聚合物结合，经过LDA去质子化后，用丙基碘或苄基溴进行烷基化。得到的烷基化产物用三氟乙酸在二氯甲烷中处理后从固体支架上断裂。具有6个和3个碳原子间隔的连接器效果优于简单的N-氨基哌嗪连接器。
• Fused bicyclic amide compounds and medicinal use thereof
  申请人：——

  公开号：US20030203909A1

  公开（公告）日：2003-10-30

  The present invention provides a compound represented by the formula (I) 1 wherein ring A is benzene, cyclohexane, pyridine, piperidine or a derivative thereof, imidazole or a derivative thereof and the like, ring B is benzene, cyclohexane, pyrrole or a derivative thereof, furan, thiophene and the like, R 1 , R 2 and R 3 are each hydrogen, alkyl, halogen, hydroxyl group, alkoxy and the like, W is hydrogen, alkyl or hydroxycarbonylalkyl, X is halogen, cyano, nitro and the like, X′ is hydrogen, halogen and the like, and Y is alkyl, hydroxyalkyl, hydroxycarbonylalkyl, aminoalkyl and the like, a salt thereof, and a pharmaceutical agent containing the compound. The compound of the present invention shows a superior inhibitory effect on the proliferation of activated lymphocyte and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.

  本发明提供了一种由以下化学式（I）1所代表的化合物，其中环A为苯、环己烷、吡啶、哌啶或其衍生物、咪唑或其衍生物等，环B为苯、环己烷、吡咯或其衍生物、呋喃、噻吩等，R1、R2和R3分别为氢、烷基、卤素、羟基、烷氧基等，W为氢、烷基或羟基羰基烷基，X为卤素、氰基、硝基等，X′为氢、卤素等，Y为烷基、羟基烷基、羟基羰基烷基、氨基烷基等，其盐和含有该化合物的药物。本发明的化合物对活化淋巴细胞的增殖具有优越的抑制作用，并可用作各种自身免疫性疾病的预防或治疗剂。
• ALKANOLAMINE, FRICTION-REDUCING AGENT, AND LUBRICATING OIL COMPOSITION
  申请人：TOSOH CORPORATION

  公开号：US20200039942A1

  公开（公告）日：2020-02-06

  To provide a friction-reducing agent containing no sulfur nor phosphorus and being excellent in friction-reducing properties, and a lubricating oil composition using it. An alkanolamine represented by the following formula is used as a friction-reducing agent: wherein A 1 and A 2 are each independently a hydroxy group or a hydrogen atom, provided that A 1 and A 2 are not hydrogen atoms at the same time, R 1 is a hydrocarbon group having at most 30 carbon atoms, R 2 to R 6 are each independently a hydrogen atom or a hydrocarbon group having at most 30 carbon atoms, and m and n are each independently an integer of from 0 to 10.

  提供一种不含硫和磷、在减摩性能方面表现优异的减摩剂，以及使用该减摩剂的润滑油组合物。作为减摩剂使用以下式表示的脂肪胺：其中A1和A2分别独立地是羟基或氢原子，前提是A1和A2不同时是氢原子，R1是最多有30个碳原子的烃基，R2到R6分别独立地是氢原子或最多有30个碳原子的烃基，m和n分别独立地是0到10的整数。
• Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16
  作者：Xian Zhang、Hongliang Wang、Yuhuan Li、Ruiyuan Cao、Wu Zhong、Zhibing Zheng、Gang Wang、Junhai Xiao、Song Li

  DOI：10.3390/molecules18055059

  日期：——

  A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackievirus A16 with low cytotoxicity.

  根据人肠道病毒71衣壳蛋白VP1的结构，通过虚拟筛选发现了一系列取代的杂芳族哌嗪和哌啶衍生物。初步生物学评价表明，化合物 8e 和 9e 对 EV71 和柯萨奇病毒 A16 具有强活性，且细胞毒性较低。