dimethyl N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-N-phenylphosphoramidoate | 1233713-89-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: dimethyl N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-N-phenylphosphoramidoate
• 英文别名: 2-(N-dimethoxyphosphorylanilino)isoindole-1,3-dione
• CAS: 1233713-89-7
• 化学式: C₁₆H₁₅N₂O₅P
• 分子量: 346.279
• InChiKey: HERNKGWYSWHGAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  76.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-苯胺基-2H-异吲哚-1,3-二酮 、 亚磷酸二甲酯 在 过氧化苯甲酰 作用下， 反应 20.0h， 以68%的产率得到dimethyl N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-N-phenylphosphoramidoate
  参考文献：
  名称：

  Efficient synthesis routes for various phthalimido phosphor esters as antimicrobial agents in terms of structure–activity relationship

  摘要：

  A series of phthalimido phosphor derivatives-alpha-amino-phosphonates, amidophosphonates, phosphonic acid diamides, and oxadiazaphospholes-were prepared by applying different types of phosphorus(III) reagents to 2-methoxy-1H-isoindole-1,3(2H)-dione and 2-anilino-1H-isoindole-1,3(2H)-dione. On the basis of bioassay results, some of the new phosphoryl imides could be considered as lead molecules to be modified in order to improve their antibiotic activity.

  DOI：

  10.1007/s00706-009-0244-1

文献信息

• Efficient synthesis routes for various phthalimido phosphor esters as antimicrobial agents in terms of structure–activity relationship
  作者：Wafaa Mahmoud Abdou、Rizk E. Khidre

  DOI：10.1007/s00706-009-0244-1

  日期：2010.2

  A series of phthalimido phosphor derivatives-alpha-amino-phosphonates, amidophosphonates, phosphonic acid diamides, and oxadiazaphospholes-were prepared by applying different types of phosphorus(III) reagents to 2-methoxy-1H-isoindole-1,3(2H)-dione and 2-anilino-1H-isoindole-1,3(2H)-dione. On the basis of bioassay results, some of the new phosphoryl imides could be considered as lead molecules to be modified in order to improve their antibiotic activity.