8-hydroxy-3,5-dimethoxy-1-prenyloxy-xanthen-9-one | 1197217-09-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 8-hydroxy-3,5-dimethoxy-1-prenyloxy-xanthen-9-one
• 英文别名: 8-Hydroxy-3,5-dimethoxy-1-(3-methylbut-2-enoxy)xanthen-9-one；8-hydroxy-3,5-dimethoxy-1-(3-methylbut-2-enoxy)xanthen-9-one
• CAS: 1197217-09-6
• 化学式: C₂₀H₂₀O₆
• 分子量: 356.375
• InChiKey: JOGYBYIYJAVPLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.01
• 重原子数：
  26.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  78.13
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  1,8-二羟基-3,5-二甲氧基氧杂蒽-9-酮 、 1-溴-3-甲基-2-丁烯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 8-hydroxy-3,5-dimethoxy-1-prenyloxy-xanthen-9-one
  参考文献：
  名称：

  Novel class of hybrid natural products as antidiabetic agents

  摘要：

  A number of O-alkylated xanthone, carbazoles and coumarins have been synthesised and screened for their in vitro anti-diabetic activity, such as glucose-6-phosphatase, glycogen phosphorylase and alpha glucosidase inhibitors. Compounds which were showing significant percentage inhibition were also tested for in vivo anti-hyperglycemic activity in sucrose loaded normal and streptozotocin (STZ)-induced diabetic rats. These compounds show 22.1, 24.4 and 26.7% and 20.8, 25.0, 20.5% lowering in sucrose loaded normal rats and STZ-induced diabetic rats at a dose of 100 mg kg-1.

  DOI：

  10.1080/14786410701824940