3-(N-cyclohexylamino)propanethiol | 3592-79-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(N-cyclohexylamino)propanethiol
• 英文别名: 1-cyclohexylamino-3-propanethiol；3-Cyclohexylamino-propan-1-thiol；3-(Cyclohexylamino)propane-1-thiol
• CAS: 3592-79-8
• 化学式: C₉H₁₉NS
• 分子量: 173.323
• InChiKey: RDYRRCJNRVLTLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  13
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  3-(N-cyclohexylamino)propanethiol 在 iron(II) sulfate 双氧水 作用下， 以 水 为溶剂， 以49%的产率得到3-(N-cyclohexylamino)propyl disulfide
  参考文献：
  名称：

  Synthesis and kinetics of the formation of N-substituted cyclic sulfinamides from secondary amine disulfides

  摘要：

  DOI：

  10.1021/jo00300a037
• 作为产物：
  描述：

  3-环己基氨基-1-丙醇 在 sodium hydroxide 、 氢溴酸 、 硫脲 作用下， 生成 3-(N-cyclohexylamino)propanethiol
  参考文献：
  名称：

  Synthesis and kinetics of the formation of N-substituted cyclic sulfinamides from secondary amine disulfides

  摘要：

  DOI：

  10.1021/jo00300a037

文献信息

• Process for producing heterocyclic compound having nitromethylene group
  申请人：UBE Industries, Ltd.

  公开号：US04665172A1

  公开（公告）日：1987-05-12

  Disclosed is a process for producing a heterocyclic compound having as the side chain group a nitromethylene group of the formula: ##STR1## wherein Y, R and n are as defined in the specification, which comprises reacting a 2,2-dihalonitroethylene compound with a 1-aminoalkanethiol compound or a 1-N-substituted derivative thereof.

  本发明公开了一种制备侧链基团为硝基亚甲基基的杂环化合物的过程，其化学式为：##STR1## 其中，Y、R和n如规范中定义的，包括将2,2-二卤代硝基乙烯化合物与1-氨基烷硫醇化合物或1-N-取代衍生物反应的步骤。
• Process for producing a 2H-1,3-thiazolidine, 2H-tetrahydro-1,3-thiazine,
  申请人：Ube Industries, Ltd.

  公开号：US04625025A1

  公开（公告）日：1986-11-25

  Disclosed is a process for producing a heterocyclic compound having a nitromethylene group as the side chain, of the formula ##STR1## wherein Y represents a hydrogen atom, a halogen atom or a lower alkyl group, R represents a hydrogen atom, an alkyl group, a cycloalkyl group, an aralkyl group, an alkenyl group, an alkynyl group or an acyl group, and n represents an integer of 2, 3 or 4, which comprises reacting a 2,2,2-trihalo-1-nitroethane compound with a 1-aminoalkanethiol compound or a 1-N-substituted derivative thereof.

  揭示了一种生产具有硝基亚甲基侧链的杂环化合物的过程，其化学式为##STR1##其中Y代表氢原子、卤原子或低碳基团，R代表氢原子、烷基团、环烷基团、芳基烷基团、烯基团、炔基团或酰基团，n代表2、3或4的整数，包括将2,2,2-三卤代-1-硝基乙烷化合物与1-氨基烷硫醇化合物或1-N-取代衍生物反应。
• Process for producing heterocyclic compound having nitromethylene group as the side chain group
  申请人：UBE INDUSTRIES, LTD.

  公开号：EP0115323A2

  公开（公告）日：1984-08-08

  Disclosed is a process for producing a heterocyclic compound having as the side chain group a nitromethylene group of the formula: wherein Y, R, and n are as defined in the specification, which comprises reacting a 2,2-dihalonitroethylene compound with a 1-aminoalkanethiol compound or a 1-N-substituted derivative thereof.

  本发明公开了一种杂环化合物的生产工艺，该杂环化合物的侧链基团是式中的一 个硝基亚甲基： 其中 Y、R 和 n 如说明书中所定义，该工艺包括使 2，2-二卤硝基乙烯化合物与 1-氨基烷硫醇化合物或其 1-N 取代衍生物反应。
• Process for producing heterocyclic compounds having nitromethylene group as the side chain group
  申请人：UBE INDUSTRIES, LTD.

  公开号：EP0135803A2

  公开（公告）日：1985-04-03

  Disclosed is a process for producing a heterocyclic compound having a nitromethylene group as the side chain, of the formula: wherein Y represents a hydrogen atom, a halogen atom or a lower alkyl group, R represents a hydrogen atom, an alkyl group, a cycloalkyl group, an aralkyl group, an alkenyl group, an alkynyl group or an acyl group, and n represents an integer of 2, 3 or 4, which comprises reacting a 2,2,2-trihalo-1-nitroethane compound with a 1-aminoalkanethiol compound or a 1-N-substituted derivative thereof.

  本发明公开了一种以硝基亚甲基为侧链的杂环化合物的生产工艺，其式如下 其中 Y 代表氢原子、卤素原子或低级烷基，R 代表氢原子、烷基、环烷基、芳基、烯基、炔基或酰基，n 代表 2、3 或 4 的整数，该工艺包括使 2，2，2-三卤-1-硝基乙烷化合物与 1-氨基烷硫醇化合物或其 1-N-取代衍生物反应。
• FLEXIBLE TUBE FOR ENDOSCOPE, ENDOSCOPE TYPE MEDICAL DEVICE, AND METHODS FOR PRODUCING THESE
  申请人：FUJIFILM Corporation

  公开号：EP3653104A1

  公开（公告）日：2020-05-20

  Provided are: a flexible tube for an endoscope, in which the flexible tube has a metal flexible-tube base material and a resin coating layer that covers the outer periphery of the flexible-tube base material, and has a primer layer containing a compound represented by formula (1) between the flexible-tube base material and the resin coating layer, the resin coating layer containing a polyurethane elastomer on the side adjacent to the primer layer; an endoscope type medical device comprising this flexible tube for an endoscope; and methods for producing the flexible tube for an endoscope and the endoscope type medical equipment. X1 and X2 each denote a hydrogen atom, an alkyl group, a cycloalkyl group, an alkenyl group, an aryl group, an acyl group, an alkoxycarbonyl group or a carbamoyl group. Y1 denotes a hydroxyl group or an alkoxy group. Y2 and Y3 each denote a hydroxyl group, an alkoxy group or an alkyl group. L denotes a single bond or a specific divalent group.

  提供了一种内窥镜用柔性管，其中柔性管具有金属柔性管基体材料和覆盖柔性管基体材料外周的树脂涂覆层，并在柔性管基体材料和树脂涂覆层之间具有含有式(1)表示的化合物的底层，树脂涂覆层在邻近底层的一侧含有聚氨酯弹性体；一种内窥镜型医疗设备，包括该内窥镜用柔性管；以及生产该内窥镜用柔性管和内窥镜型医疗设备的方法。X1和X2分别表示氢原子、烷基、环烷基、烯基、芳基、酰基、烷氧羰基或氨基甲酰基。Y1 表示羟基或烷氧基。Y2 和 Y3 分别表示羟基、烷氧基或烷基。L 表示单键或特定的二价基团。