5'-mercapto-5'-deoxythymidine 5'-S-triphosphate | 56201-17-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 2 '，5'-二脱氧核苷
• 英文名称: 5'-mercapto-5'-deoxythymidine 5'-S-triphosphate
• 英文别名: S-(tetrahydroxy-[1]triphosphoryl)-5'-thio-thymidine；[(2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methylsulfanyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid
• CAS: 56201-17-3
• 化学式: C₁₀H₁₇N₂O₁₃P₃S
• 分子量: 498.238
• InChiKey: RIXFQTJRQVRELR-XLPZGREQSA-N

物化性质

• 密度：
  1.927±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.45
• 重原子数：
  29.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  234.91
• 氢给体数：
  6.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  5'-mercapto-5'-deoxythymidine 5'-S-triphosphate 在 silver nitrate 、 1,4-二巯基-2,3-丁二醇 作用下， 以 水 为溶剂， 生成 5'-thio-thymidine
  参考文献：
  名称：

  [EN] CLEAVABLE CYCLIC LOOP NUCLEOTIDES FOR NANOPORE SEQUENCING
  [FR] NUCLÉOTIDES À BOUCLE CYCLIQUE CLIVABLES POUR SÉQUENÇAGE DE NANOPORES

  摘要：

  In one aspect, the disclosed technology relates to nanopore sequencing with a polynucleotide comprising a plurality of nucleotides, wherein each nucleotide comprises a linker construct between two positions of the nucleotide, wherein the linker construct optionally comprises a reporter moiety corresponding to the identity of the nucleotide, and wherein the linker construct is a part of the cleavable cyclic loop nucleotide comprising a cleavable site. In some embodiments, the nucleotides further comprise arresting constructs for slowing or halting the polynucleotide translocation through a nanopore.

  公开号：

  WO2023215506A1
• 作为产物：
  描述：

  3'-O-acetylthymidine 在 吡啶 、 三正丁胺 、 PS(ONa)2*10H₂O 、 Tri-imidazolyl-(1)-phosphinoxid 、 ammonium bicarbonate 、 三丁基焦磷酸铵 、 potassium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 46.67h， 生成 5'-mercapto-5'-deoxythymidine 5'-S-triphosphate
  参考文献：
  名称：

  Shirokova, E. A.; Shipitsyn, A. V.; Kuznetsova, E. V., Russian Journal of Bioorganic Chemistry, 1993, vol. 19, # 12, p. 736 - 741

  摘要：

  DOI：

文献信息

• Shirokova, E. A.; Shipitsyn, A. V.; Kuznetsova, E. V., Russian Journal of Bioorganic Chemistry, 1993, vol. 19, # 12, p. 736 - 741
  作者：Shirokova, E. A.、Shipitsyn, A. V.、Kuznetsova, E. V.、Viktorova, L. S.、Kraevskii, A. A.

  DOI：——

  日期：——
• [EN] CLEAVABLE CYCLIC LOOP NUCLEOTIDES FOR NANOPORE SEQUENCING<br/>[FR] NUCLÉOTIDES À BOUCLE CYCLIQUE CLIVABLES POUR SÉQUENÇAGE DE NANOPORES
  申请人：[en]ILLUMINA, INC.

  公开号：WO2023215506A1

  公开（公告）日：2023-11-09

  In one aspect, the disclosed technology relates to nanopore sequencing with a polynucleotide comprising a plurality of nucleotides, wherein each nucleotide comprises a linker construct between two positions of the nucleotide, wherein the linker construct optionally comprises a reporter moiety corresponding to the identity of the nucleotide, and wherein the linker construct is a part of the cleavable cyclic loop nucleotide comprising a cleavable site. In some embodiments, the nucleotides further comprise arresting constructs for slowing or halting the polynucleotide translocation through a nanopore.