2,4-O-ethylidene-aldehydo-D-erythrose | 901783-93-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 2,4-O-ethylidene-aldehydo-D-erythrose
• 英文别名: 2,4-O-ethylidene-D-erythrose；2,4-ethylidene-D-erythrose；2.4-O-Aethyliden-D-erythrose；2,4-O-Ethyliden-D-erythrose；(4R,5R)-5-Hydroxy-2-methyl-1,3-dioxane-4-carbaldehyde
• CAS: 901783-93-5
• 化学式: C₆H₁₀O₄
• 分子量: 146.143
• InChiKey: HVAFLFRNUVFTBL-UVCATTPVSA-N

物化性质

• 沸点：
  278.2±40.0 °C(Predicted)
• 密度：
  1.303±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4-O-ethylidene-aldehydo-D-erythrose 以 硫酸 为溶剂， 反应 0.25h， 以11.5 g的产率得到(2R,3R)-2,3,4-三羟基丁醛
  参考文献：
  名称：

  The allyl and benzyl glycosides of d-erythrose

  摘要：

  DOI：

  10.1016/s0008-6215(00)81078-2
• 作为产物：
  描述：

  4,6-O-乙亚基-D-葡萄糖 在 sodium periodate 作用下， 以92%的产率得到2,4-O-ethylidene-aldehydo-D-erythrose
  参考文献：
  名称：

  Jary, Jiri; Marek, Miroslav, Collection of Czechoslovak Chemical Communications, 1980, vol. 45, # 12, p. 3571 - 3582

  摘要：

  DOI：

文献信息

• Reactions of d-glucose, d-xylose, and d-erythrose with 2-methyl-2-propanethiol
  作者：F.J. Lopez Aparicio、F. Zorilla Benitez、F. Santoyo Gonzalez、J.L. Asensio Rosell

  DOI：10.1016/0008-6215(87)80162-3

  日期：1987.6

  Abstract The reaction of d -glucose and d -xylose with 2-methyl-2-propanethiol in conc. hydrochloric acid yielded tert-butyl 1-thioglycopyranosides (products of kinetic and thermodynamic control). Di-tert-butyl dithioacetals (12–14) were obtained from the acetylated aldehydo-derivatives of d -glucose, d -xylose, and d -erythrose. On brief treatment with conc. hydrochloric acid, 12 and 13 gave tert-butyl

  摘要d-葡萄糖和d-木糖与2-甲基-2-丙硫醇在浓溶液中的反应。盐酸得到叔丁基1-硫代糖吡喃糖苷（动力学和热力学控制的产物）。二叔丁基二硫缩醛（12-14）从d-葡萄糖，d-木糖和d-赤藓糖的乙酰化醛基衍生物获得。在简短的治疗与浓。用盐酸12和13得到1-硫代-α-和-β-吡喃葡萄糖苷叔丁基，而14得到相应的呋喃糖苷。
• Method of forming glycosidic bonds from thioglycosides using an N,N-dialkylsulfinamide
  申请人：——

  公开号：US20040019198A1

  公开（公告）日：2004-01-29

  A method of forming a glycosidic bond utilizing an activated thioglycoside is disclosed. The thioglycoside is activated by an N,N-dialkylsulfinamide and trifluoromethanesulfonic anhydride. The method allows the facile synthesis of disaccharides, oligosacchraides, and polysaccharides in solution or on a polymer support.

  揭示了一种利用活化硫代糖苷键的方法。该硫代糖苷经N,N-二烷基亚磺酰胺和三氟甲磺酸酐激活。该方法允许在溶液中或在聚合物支撑上轻松合成二糖、寡糖和多糖。
• Novel nitrosourea compounds and process for preparing the same
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US04182757A1

  公开（公告）日：1980-01-08

  A nitrosourea compound of the formula: ##STR1## wherein R.sup.1 is alkyl of one to six carbon atoms, hydroxyalkyl of one to six carbon atoms, alkenyl of three to five carbon atoms or alkynyl of three to five carbon atoms, R.sup.2 is aldopentofuranosyl, aldo-pentopyranosyl, aldo-hexopyranosyl, O-aldo-hexopyranosyl-(1.fwdarw.4)-aldo-hexopyranosyl or a group of the formula: --CH.sub.2 (CHOH).sub.n CH.sub.2 OH, and wherein n is zero or an integer of one to four. A method of preparation is disclosed whereby said nitrosourea compound is prepared by the nitrosation of a compound of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are the same as above. Said nitrosourea compound is useful as an anti-tumor or anti-leukemic agent.

  一种硝基脲化合物，化学式如下：##STR1## 其中R.sup.1是碳原子数为1至6的烷基，碳原子数为1至6的羟基烷基，碳原子数为3至5的烯基或碳原子数为3至5的炔基，R.sup.2是醛基五糖苷、醛基五糖苷、醛基六糖苷、O-醛基六糖苷-(1.fwdarw.4)-醛基六糖苷或化学式为：--CH.sub.2 (CHOH).sub.n CH.sub.2 OH的基团，其中n为零或1至4的整数。公开了一种制备方法，通过对化合物的亚硝化来制备所述硝基脲化合物，其中该化合物的化学式如下：##STR2## 其中R.sup.1和R.sup.2与上述相同。该硝基脲化合物可用作抗肿瘤或抗白血病药物。
• SODIUM CHANNEL BLOCKERS
  申请人：PARION SCIENCES, INC.

  公开号：US20150376146A1

  公开（公告）日：2015-12-31

  The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.

  本发明涉及钠通道阻滞剂。本发明还包括使用这些创新性钠通道阻滞剂的各种治疗方法。
• Methods for the electrolytic production of erythrose or erythritol
  申请人：Stapley Jonathan A.

  公开号：US20070181437A1

  公开（公告）日：2007-08-09

  Methods for the production of erythrose and/or erythritol are provided herein. Preferably, the methods include the step of electrolytic decarboxylation of a ribonic acid or arabinonic acid reactant to produce erythrose. Optionally, the reactant can be obtained from a suitable hexose sugar, such as allose, altrose, glucose, fructose or mannose. The erythrose product can be hydrogenated to produce erythritol.

  本文提供了生产赤糖醇和/或赤糖的方法。优选的方法包括通过电解脱羧化的核糖酸或阿拉伯糖酸反应物生产赤糖。可选地，反应物可以从适当的己糖，如阿洛糖、阿尔糖、葡萄糖、果糖或甘露糖中获得。赤糖产品可以经过加氢反应产生赤糖醇。