N,N'-diisopentyl-ethylenediamine | 61798-19-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-diisopentyl-ethylenediamine
• 英文别名: N,N'-Diisopentyl-aethylendiamin；N~1~,N~2~-Bis(3-methylbutyl)ethane-1,2-diamine；N,N'-bis(3-methylbutyl)ethane-1,2-diamine
• CAS: 61798-19-4
• 化学式: C₁₂H₂₈N₂
• 分子量: 200.368
• InChiKey: GHPRYRTUTIVKFX-UHFFFAOYSA-N

物化性质

• 沸点：
  252.5±8.0 °C(Predicted)
• 密度：
  0.817±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-diisopentyl-ethylenediamine 、 十一烷酸 生成 N,N'-(Ethane-1,2-diyl)bis[N-(3-methylbutyl)undecanamide]
  参考文献：
  名称：

  DE2515146

  摘要：

  公开号：
• 作为产物：
  描述：

  N,N'-diisopentyl-N,N'-ethanediyl-bis-toluene-4-sulfonamide 在 硫酸 作用下， 生成 N,N'-diisopentyl-ethylenediamine
  参考文献：
  名称：

  Vyas; Dhopate, Journal Of Scientific and Industrial Research, 1959, vol. 18 C, p. 6,9

  摘要：

  DOI：

文献信息

• Salts in the Preparation of Cephalosporin Antibiodies
  申请人：Senthilkumar Udayampalayam P.

  公开号：US20080306256A1

  公开（公告）日：2008-12-11

  The present invention relates to an improved process for the preparation of cephalosporin antibiotics of formula (I). The present invention also provides new salts of compound of formula (II) and a process for the preparation of these new salts, where n=0.5 to 2. The present invention also provides a process for the preparation of compound of formula (I) using the new salts of formula (II).

  本发明涉及一种改进的制备式(I)头孢菌素类抗生素的方法。本发明还提供了式(II)化合物的新盐，并提供了制备这些新盐的方法，其中n=0.5至2。本发明还提供了使用式(II)的新盐制备式(I)化合物的方法。
• AMINOALCOHOL LIPIDOIDS AND USES THEREOF
  申请人：Mahon Kerry Peter

  公开号：US20100331234A1

  公开（公告）日：2010-12-30

  Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

  本文介绍了通过将胺与环氧末端化合物反应制备氨基醇脂质体的方法。还提供了从商业起始材料制备氨基醇脂质体的方法。氨基醇脂质体可以从外消旋或立体化学纯的环氧化合物制备。氨基醇脂质体或其盐形式最好是可生物降解和生物相容的，并可用于各种药物递送系统。由于这些氨基醇脂质体化合物的氨基基团，它们特别适用于多核苷酸的递送。已制备包含发明性脂质体和多核苷酸的复合物、胶束、脂质体或颗粒。发明性脂质体还可用于制备药物递送的微粒。鉴于它们缓冲其周围环境pH值的能力，它们特别适用于递送不稳定的药物。
• Aminoalcohol lipidoids and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：US10189802B2

  公开（公告）日：2019-01-29

  Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

  本文介绍了通过胺与环氧化物封端化合物反应制备氨基醇脂质的方法。还提供了从市售起始原料制备氨基醇类脂质的方法。氨基醇脂质可由外消旋或立体化学纯环氧化物制备。氨基醇类脂质或其盐类最好具有生物降解性和生物相容性，可用于各种给药系统。考虑到这些氨基醇类脂化合物的氨基，它们特别适合用于多核苷酸的给药。现已制备出含有本发明类脂化合物和多核苷酸的复合物、胶束、脂质体或颗粒。本发明的类脂质还可用于制备给药微粒。由于本发明脂质具有缓冲周围环境 pH 值的能力，因此在递送易变药剂方面特别有用。
• DE2515146
  申请人：——

  公开号：——

  公开（公告）日：——
• Ismiev, A. I.; Farzaliev, V. M.; Allakhverdiev, M. A., Journal of Organic Chemistry USSR (English Translation), 1991, vol. 27, # 6.2, p. 1196
  作者：Ismiev, A. I.、Farzaliev, V. M.、Allakhverdiev, M. A.

  DOI：——

  日期：——