thieno[3,2-b]pyridine 1,1-dioxide | 37049-40-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: thieno[3,2-b]pyridine 1,1-dioxide
• 英文别名: Thieno<3,2-b>pyridin-1,1-dioxid；Thieno[3,2-b]pyridine 1,1-dioxide
• CAS: 37049-40-4
• 化学式: C₇H₅NO₂S
• mdl: MFCD18803425
• 分子量: 167.188
• InChiKey: VBTSDTXSLUHVBE-UHFFFAOYSA-N

物化性质

• 沸点：
  418.1±37.0 °C(Predicted)
• 密度：
  1.497±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  thieno[3,2-b]pyridine 1,1-dioxide 、 并四苯 以 xylene 为溶剂， 反应 96.0h， 以18%的产率得到endo-cis-5a,6,13,13a-Tetrahydro-6,13<1',2'>-benzenoanthra<2',3':4,5>thieno<3,2-b>pyridine 5,5-dioxide
  参考文献：
  名称：

  Klemm, L. H.; Sur, Sandip K.; Louris, John N., Journal of Heterocyclic Chemistry, 1990, vol. 27, # 6, p. 1721 - 1725

  摘要：

  DOI：
• 作为产物：
  描述：

  噻吩[3,2-B]吡啶 在 盐酸 、 sodium hypochlorite 作用下， 生成 thieno[3,2-b]pyridine 1,1-dioxide
  参考文献：
  名称：

  Klemm,L.H.; Merrill,R.E., Journal of Heterocyclic Chemistry, 1972, vol. 9, p. 293 - 298

  摘要：

  DOI：

文献信息

• 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE
  申请人：Horiuchi Yoshihiro

  公开号：US20120225876A1

  公开（公告）日：2012-09-06

  Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof (In the formula, A represents a group that is represented by formula (A-1); R 1a and R 1b may be the same or different and each independently represents a C 1-6 alkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; X 1 represents a hydroxyl group or an aminocarbonyl group; Z 1 represents a single bond or the like; and R 2 represents an optionally substituted C 1-6 alkyl group, an optionally substituted C 6-10 aryl group or the like.)

  公开了一种由公式(1)表示的化合物或其药理可接受的盐(在公式中，A代表由公式(A-1)表示的基团；R1a和R1b可以相同或不同，每个独立地表示一个可以由一个到三个卤素原子取代的C1-6烷基；m和n各自独立地表示0-5之间的整数；X1代表羟基或氨基甲酰基；Z1代表单键等；R2代表一个可选地取代的C1-6烷基，一个可选地取代的C6-10芳基等)。
• PROCESS OF A QUATERNARY AMMONIUM SALT USING PHOSPHATE
  申请人：AE Nobuyuki

  公开号：US20110263848A1

  公开（公告）日：2011-10-27

  The present invention relates to a novel process for preparing quaternary ammonium salt derivatives.

  本发明涉及一种制备季铵盐衍生物的新工艺。
• PROCESS OF A QUATERNARY AMMONIUM SALT
  申请人：AE Nobuyuki

  公开号：US20110263847A1

  公开（公告）日：2011-10-27

  The present invention relates to a novel process for preparing quaternary ammonium salt derivatives.

  本发明涉及一种制备季铵盐衍生物的新工艺。
• Fused thiophone derivatives and drugs containing the same as the active ingredient
  申请人：——

  公开号：US20030073706A1

  公开（公告）日：2003-04-17

  The present invention relates to a fused thiophene derivative of the formula (I) (wherein all the symbols are defined as described in the specification) and an inhibitor of producing interleukin-6 and/or interleukin-12 comprising the said derivative as an active ingredient. A fused thiophene derivative of the formula (I) is useful as an agent for the prevention and/or treatment of various inflammatory diseases, sepsis, multiple myeloma, plasma cell leukemia, osteoporosis, cachexia, psoriasis, nephritis, renal cell carcinoma, Kaposi's sarcoma, rheumatoid arthritis, gammopathy, Castleman's disease, atrial myxoma, diabetes mellitus, autoimmune diseases, hepatitis, multiple sclerosis, colitis, graft versus host immune diseases, infectious diseases. 1

  本发明涉及公式（I）的融合噻吩衍生物（其中所有符号如规范中所述）和一种抑制产生白细胞介素-6和/或白细胞介素-12的抑制剂，其包含所述衍生物作为活性成分。公式（I）的融合噻吩衍生物可用作预防和/或治疗各种炎症性疾病、败血症、多发性骨髓瘤、浆细胞白血病、骨质疏松症、消瘦症、银屑病、肾炎、肾细胞癌、卡波西肉瘤、类风湿性关节炎、免疫球蛋白病、卡斯特曼病、心房黏液瘤、糖尿病、自身免疫疾病、肝炎、多发性硬化症、结肠炎、移植物抗宿主免疫疾病、传染病的药剂。
• PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS
  申请人：Rogel Olivier

  公开号：US20090247577A1

  公开（公告）日：2009-10-01

  Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (disorder) that depends on the activity of beta-secretase and/or the generation of beta-amyloid and the subsequent aggregation into oligomers and fibrils; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on the activity of beta-secretase and/or the generation of beta-amyloid and the subsequent aggregation into oligomers and fibrils; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound. The substituted pyrrolidine compounds are especially of the formula I, wherein the substituents are as defined in the specification.

  小说3-单取代、3,4-双取代和3,4,4-三取代吡咯烷化合物，这些化合物用于诊断和治疗温血动物，特别是用于治疗依赖于β-分泌酶活性和/或β-淀粉样蛋白生成及其后续寡聚体和纤维聚集的疾病（紊乱）；该类化合物的使用用于制备用于治疗依赖于β-分泌酶活性和/或β-淀粉样蛋白生成及其后续寡聚体和纤维聚集的疾病的药物配方；包括所述取代的吡咯烷化合物的药物配方和/或包括给予该取代的吡咯烷化合物的治疗方法。所述取代的吡咯烷化合物特别是公式I的，其中取代基如规范中所定义。