4-甲氧基-1-萘酸氯 | 70696-57-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 4-甲氧基-1-萘酸氯
• 中文别名: 4-甲氧基-1-萘甲酰氯
• 英文名称: 4-methoxy-1-naphthoic acid chloride
• 英文别名: 4-methoxy-1-naphthoyl chloride；4-methoxy-[1]naphthoyl chloride；4-Methoxy-naphthoesaeure-(1)-chlorid；4-Methoxy-[1]naphthoylchlorid；4-methoxy-1-naphthalenecarbonyl chloride；4-methoxynaphthalenecarbonyl chloride；4-methoxynaphthalene-1-carbonyl chloride
• CAS: 70696-57-0
• 化学式: C₁₂H₉ClO₂
• 分子量: 220.655
• InChiKey: DCHGODSBSWBLPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-甲氧基-1-萘酸氯 在 劳森试剂 、 4-二甲氨基吡啶 、 三乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 48.0h， 生成 S-methyl 4-methoxynaphthalene-1-carbodithioate
  参考文献：
  名称：

  Facile Synthesis of Lipophilic δ-Amino Acid Conjugates from 4-Alkoxy-dithionaphthoic Acids

  摘要：

  Novel 4-alkoxy-dithionaphthoic acids were prepared and shown to be valuable synthons for delta-amino acid conjugates. These dithioacids are efficiently synthesized and purified, stable to storage, and easily derivatized to facilitate thioacylation chemistry. To this end, we have demonstrated dithionaphthoic acids (6) to successfully undergo coupling with both protected and unprotected amino acids, giving rise to stable thioamide conjugates (8 and 9).

  DOI：

  10.1080/00397911.2011.565142
• 作为产物：
  描述：

  4-甲氧基-1-萘甲酸 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 为溶剂， 生成 4-甲氧基-1-萘酸氯
  参考文献：
  名称：

  一种 ROS 响应供体，通过形成基于苯并恶唑的荧光团来自我报告其 H2S 传递

  摘要：

  硫化氢 (H 2 S) 是一种内源性信号分子，已知在神经保护、血管舒张和激素调节中发挥着关键作用。为了进一步探索 H 2 S 的生物效应，需要促进其生物传递的精制供体，特别是在特定（病理）生理条件下。在本研究中，我们证明邻位取代的芳基硼酸酯为基于硫代酰胺的供体释放H 2 S提供了两种独特且不同的途径：路易斯酸促进的水解和活性氧（ROS）诱导的氧化/环化。通过详细的结构-活性关系研究，确定了仅通过后一种机制抵抗水解和释放 H 2 S 的供体，这具有提供潜在有用的杂环作为这种新型化学的唯一副产物的额外好处。为了强调这一点，我们开发了一种 ROS 激活供体 ( QH642 )，它在 H 2 S 传递过程中同时合成基于苯并恶唑的荧光团。与早期的自我报告供体相比，这种设计的一个明显优点是，只有当 H 2 S 已从供体中排出时才有可能形成荧光团。这一关键功能消除了误报的可能性，并更准确地描述了反应进程和

  DOI：

  10.1021/jacs.3c10446

文献信息

• [EN] THERAPEUTIC COMPOUNDS: PYRIDINE AS SCAFFOLD<br/>[FR] COMPOSES THERAPEUTIQUES DANS LESQUELS LA PYRIDINE EST UTILISEE COMME SQUELETTE
  申请人：ASTRAZENECA AB

  公开号：WO2005115986A1

  公开（公告）日：2005-12-08

  Compounds of formulas I, IA, and IB or IC or pharmaceutically acceptable salts thereof: wherein A, A1, A2, A3, A4, R2, R3, R4 and n are as defined in the specifications well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

  其中A、A1、A2、A3、A4、R2、R3、R4和n的化合物的公式I、IA和IB或IC或其药学上可接受的盐：其中A、A1、A2、A3、A4、R2、R3、R4和n的定义如规范中所述，以及包括这些化合物的盐和药物组合物已经准备好。它们在治疗中很有用，特别是在疼痛管理中。
• Behavior of Naphthoyloxyl and Methoxynaphthoyloxyl Radicals Generated from the Photocleavage of Dinaphthoyl Peroxides and 1-(Naphthoyloxy)-2-pyridones
  作者：Toshihiro Najiwara、Ji-ichiro Hashimoto、Katsunori Segawa、Hirochika Sakuragi

  DOI：10.1246/bcsj.76.575

  日期：2003.3

  was compared with that of unsubstituted naphthoyloxyl radicals. The introduction of a methoxy group in the naphthalene ring stabilizes the naphthoyloxyl radicals to prevent their decarboxylation completely and reduces remarkably their reactivities in the addition to olefins and hydrogen-atom abstraction. The structure of the naphthoyloxyl radicals was discussed on the basis of their absorption spectra

  1-Naphthoyloxyl 和 2-naphthoyloxyl 自由基是由二萘甲酰过氧化物和 1-(naphthoyloxy)-2-pyridones 在乙腈中的光裂解产生的。前体之间产物分布的差异归因于双键断裂对单线态过氧化物分解的贡献。相应的（甲氧基萘酰氧基）吡啶酮还生成了一系列甲氧基萘酰氧基自由基，并将它们的行为与未取代的萘酰氧基自由基的行为进行了比较。在萘环中引入甲氧基可以稳定萘酰氧基自由基以完全防止它们脱羧并显着降低它们在加入烯烃和夺取氢原子时的反应性。
• Palladium-catalyzed directing group-assisted C8-triflation of naphthalenes
  作者：Zhi-Wei Yang、Qi Zhang、Yuan-Ye Jiang、Lei Li、Bin Xiao、Yao Fu

  DOI：10.1039/c6cc01732k

  日期：——

  The transition-metal-catalyzed direct triflation of naphthyl amides and naphthyl ketones has been accomplished for the first time.

  过渡金属催化的萘酰胺和萘酮的直接三氟甲磺酸酯化已首次实现。
• Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds
  申请人：Hangauer G. David

  公开号：US20050153366A1

  公开（公告）日：2005-07-14

  The present invention relates to 1,4-disubstituted naphthalene scaffold compounds and other closely related scaffold compounds. The present invention also relates to combinatorial libraries of such compounds. In addition, the present invention relates to a method of identifying a protein-protein interaction antagonist. The method first involves providing a compound as described herein. Next, the compound is contacted with interacting proteins of a protein-protein interaction target complex, whereby the compound is allowed to compete with the interacting proteins. Then, the activity of the compound for inhibiting formation of the protein-protein interaction target complex is measured. Finally, the compound that inhibits formation of the protein-protein interaction target complex is identified as a protein-protein interaction antagonist. Also disclosed is a method for modulating a protein-protein interaction. The method involves contacting interacting proteins of a protein-protein interaction target with a compound as described herein, whereby the protein-protein interaction between the interacting proteins is modulated.

  本发明涉及1,4-二取代萘骨架化合物及其他密切相关的骨架化合物。本发明还涉及这些化合物的组合式库。此外，本发明涉及一种鉴定蛋白质-蛋白质相互作用拮抗剂的方法。该方法首先涉及提供本文描述的化合物。接下来，将该化合物与蛋白质-蛋白质相互作用目标复合物的相互作用蛋白质接触，使该化合物能够与相互作用蛋白质竞争。然后，测量该化合物抑制蛋白质-蛋白质相互作用目标复合物形成的活性。最后，确定抑制蛋白质-蛋白质相互作用目标复合物形成的化合物为蛋白质-蛋白质相互作用拮抗剂。还公开了一种调节蛋白质-蛋白质相互作用的方法。该方法涉及将本文描述的化合物与蛋白质-蛋白质相互作用目标的相互作用蛋白质接触，从而调节相互作用蛋白质之间的蛋白质-蛋白质相互作用。
• New pyrrole derivatives, process for their preparation and therapeutic
  申请人：Albert Rolland S.A.

  公开号：US04194003A1

  公开（公告）日：1980-03-18

  The present invention relates to a compound selected from the compounds of the formula: ##STR1## in which: R.sup.1 is selected from hydrogen and C.sub.1-4 alkyl, R is selected from C.sub.1-6 alkyl, benzyl and phenyl, Ar is selected from phenyl, phenyl monosubstituted with a group selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy and halogen, phenyl polysubstituted with groups selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy and halogen, naphthyl, naphthyl monosubstituted with a group selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy and halogen, naphthyl polysubstituted with groups selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy and halogen, thienyl, furyl and pyrrolyl and > Z represents a carbonyl group, a group of the formula >C.dbd.NOH or an alcoholic group >CHOH and the salts of acids of formula (I) with physiologically acceptable bases. Said compounds are useful for the treatment of hyperuricemia.

  本发明涉及一种从以下公式的化合物中选择的化合物：##STR1##其中：R.sup.1从氢和C.sub.1-4烷基中选择，R从C.sub.1-6烷基、苄基和苯基中选择，Ar从苯基、苯基单取代基（所选自C.sub.1-4烷基、C.sub.1-4烷氧基和卤素）、苯基多取代基（所选自C.sub.1-4烷基、C.sub.1-4烷氧基和卤素）、萘基、萘基单取代基（所选自C.sub.1-4烷基、C.sub.1-4烷氧基和卤素）、萘基多取代基（所选自C.sub.1-4烷基、C.sub.1-4烷氧基和卤素）、噻吩基、呋喃基和吡咯基，> Z代表羰基，一个公式的基团 >C.dbd.NOH 或一个醇基团 >CHOH，以及具有生理学上可接受的碱的酸的盐的化合物。这些化合物对于治疗高尿酸血症是有用的。