9,9-芴二丙酸 | 4425-95-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: 9,9-芴二丙酸
• 中文别名: 9,9-二(2-丙酸)芴
• 英文名称: 9,9-Bis-<2-carboxy-aethyl>-fluoren
• 英文别名: Fluorene-9,9-dipropionic acid；3-[9-(2-carboxyethyl)fluoren-9-yl]propanoic acid
• CAS: 4425-95-0
• 化学式: C₁₉H₁₈O₄
• 分子量: 310.35
• InChiKey: HVIAEALBBMNFIW-UHFFFAOYSA-N

物化性质

• 熔点：
  273-274 °C
• 沸点：
  567.0±23.0 °C(Predicted)
• 密度：
  1.270±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2916399090
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  9,9-芴二丙酸 在 PPA 作用下， 生成 1,2,11,12-tetrahydro-benzo[hi]fluoranthene-3,10-dione
  参考文献：
  名称：

  The Synthesis of Spiro[cyclohexane-1,9'-fluorene] and Related Compounds¹

  摘要：

  DOI：

  10.1021/jo01067a060
• 作为产物：
  描述：

  芴 在 氢氧化钾 、 苄基三甲基氢氧化铵 作用下， 以 1,4-二氧六环 、 乙二醇 为溶剂， 反应 3.5h， 生成 9,9-芴二丙酸
  参考文献：
  名称：

  Synthesis and Monoamine Transporter Binding Properties of 2,3-Cyclo Analogues of 3β-(4‘-Aminophenyl)-2β-tropanemethanol

  摘要：

  A series of cyclo-3 beta-(4-aminophenyl)-2 beta-tropanemethanol analogues (5a-m) possessing varying linker groups between the 2- and 3-position on the tropane ring were synthesized and evaluated for their monoamine transporter binding properties. The results show that binding to the dopamine and serotonin transporters (DAT and 5-HTT) is highly dependent on the specific linker used. Cyclo-3 beta-(4-aminophenyl)-2 beta-tropanemethanol pimelic acid ester/amide (5b) had an IC50 of 3.8 nM at the DAT. Cyclo-3 beta-(4-aminophenyl)2 beta-tropanemethanol sebacic acid ester/amide (5e) had a K-i of 1.9 nM at the 5-HTT and was 68- and 737-fold selective for the 5-HTT relative to the DAT and NET. Small changes to the size as well as the electrostatic and hydrophobic properties of the 2,3-linker in 5b or 5e led to much less potent analogues at all three transporters. These results suggest that the high affinity for 5b and 5e at the DAT and 5-HTT may be due to their specific conformational properties.

  DOI：

  10.1021/jm060287w

文献信息

• Preparation process of dicarboxylic acid compounds
  申请人：Adchemco Corporation

  公开号：EP1215192A3

  公开（公告）日：2003-02-12

  Carboxylic acid compounds, each of which has an indene skeleton and represented by the following formula (2) or a fluorene skeleton and represented by the following formula (3), are each prepared by reacting an unsaturated carboxylic acid compound represented by the following formula (1) with indene or fluorene in the presence of a strong base catalyst: wherein R1, R2, R3 and R4 each independently represents an atom or group selected from a hydrogen atom, an alkyl group, an aryl group or a carboxyl group, with the proviso that at least one of R3 and R4 contains a carboxyl group or a salt thereof or a carboxylic ester group.

  含有吲哚骨架并由以下式（2）表示的羧酸化合物，或含有芴骨架并由以下式（3）表示的羧酸化合物，每种均通过将以下式（1）表示的不饱和羧酸化合物与吲哚或芴在强碱催化剂存在下反应制备：其中R1、R2、R3和R4各自独立地表示从氢原子、烷基、芳基或羧基中选择的原子或基团，但R3和R4中至少有一个含有羧基或其盐或羧酸酯基。
• Über Fluoranthen-Derivate. 2. Mitteilung. Über ein neues spirocyclisches Ringsystem
  作者：K. Hoffmann、E. Tagmann

  DOI：10.1002/hlca.19490320514

  日期：——

  Ausgehend von Fluoren- und Fluoranthen-derivaten wurde die Herstellung eines neuen spirocyclischen Ringsystems beschrieben. Es besteht aus vier Sechsringen und einem Fünfring.

  从芴和荧蒽衍生物开始，已经描述了新的螺环系统的制备。它由四个六元环和一个五元环组成。
• NEGATIVELY BIREFRINGENT POLYESTERS AND OPTICAL FILMS
  申请人：Wang Lei

  公开号：US20120170118A1

  公开（公告）日：2012-07-05

  Presently described are multilayer optical films, oriented polyester films, negatively birefringent copolyester polymers, fluorene monomers, and polyester polymers prepared from such fluorene monomers. In one embodiment, the multilayer optical film comprises at least one first birefringent optical layer; and at least one second optical layer having a lower birefringence than the first optical layer; wherein at least one of the optical layers comprises a negatively birefringent polyester polymer comprising a backbone and repeat units comprising at least one pendent aromatic group that is conformationally locked relative to the backbone.

  本文介绍了多层光学薄膜、取向聚酯薄膜、负双折射共聚酯聚合物、芴单体以及由此类芴单体制备的聚酯聚合物。在一种实施例中，多层光学薄膜包括至少一个第一双折射光学层；以及至少一个比第一光学层具有较低双折射率的第二光学层；其中至少一个光学层包括一种负双折射的聚酯聚合物，该聚酯聚合物包括主链和重复单元，其中至少有一个悬挂的芳香基固定在主链上。
• Fluorinated aromatic compounds and the use of the same in liquid crystal mixtures
  申请人：——

  公开号：US20040124399A1

  公开（公告）日：2004-07-01

  The invention relates to fluorinated aromatics of the formula (I) 1 where X is CH 2 , C═O, CF 2 , O or S, Y is H or F, with the proviso that Y has to be F when X is CH 2 , and where the other parameters are as defined in claim 1, and also to their use in liquid-crystal mixtures, and also to liquid-crystal mixtures comprising these compounds and to liquid-crystal displays comprising these mixtures.

  本发明涉及式(I)的氟化芳香化合物1，其中X为CH2、C═O、CF2、O或S，Y为H或F，但当X为CH2时，Y必须为F。其他参数如权利要求1所定义，以及它们在液晶混合物中的使用，以及包含这些化合物的液晶混合物和包含这些混合物的液晶显示器。
• RESIN PRODUCED BY POLYCONDENSATION, AND RESIN COMPOSITION
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP3141570A1

  公开（公告）日：2017-03-15

  According to one embodiment, a polyester resin is provided, which includes a structural unit derived from a compound represented by general formula (1), a structural unit derived from a compound represented by general formula (2), and a structural unit derived from a dicarboxylic acid or a derivative thereof.

  根据其中一个实施方案，提供了一种聚酯树脂，它包括由通式（1）代表的化合物衍生的结构单元、由通式（2）代表的化合物衍生的结构单元和由二羧酸或其衍生物衍生的结构单元。